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Short Communication


The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery

Shelby L Mancini, Peter Early, Karen Munana, Natasha Olby, Christopher Mariani, Bethany Pastina.


Cited By:1

Abstract
Background: Cytarabine (CA) is used to treat dogs with meningoencephalomyelitis of unknown etiology (MUE) by subcutaneous (SC) or intravenous (IV) administration.
Aim: The objective was to investigate transdermal iontophoresis and rectal administration as alternative routes of CA delivery.
Methods: Two client-owned dogs with MUE were studied. The ActivaPatch® IONTOGO™ 12.0 iontophoresis drug delivery system delivered 200 mg/m^2 CA transdermally. Blood samples were collected by sparse sampling technique after initiation of the device. At another visit, 100 mg/m^2 CA was administered rectally. Blood samples were collected by sparse sampling technique after administration. Plasma CA concentrations were measured by high-pressure liquid chromatography (HPLC).
Results: The concentration of plasma CA after transdermal and rectal administration was below the limits of quantification (0.1ug/mL) in all samples suggesting inadequate bioavailability with transdermal and rectal administration.
Conclusion: Transdermal and rectal CA administration are not reasonable alternative routes of delivery.

Key words: dog, meningoencephalitis, cytarabine, bioavailability


 
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How to Cite this Article
Pubmed Style

Mancini SL, Early P, Munana K, Olby N, Mariani C, Pastina B, . The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. Open Vet J. 2021; 11(1): 36-38. doi:10.4314/ovj.v11i1.6

Web Style

Mancini SL, Early P, Munana K, Olby N, Mariani C, Pastina B, . The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. https://www.openveterinaryjournal.com/?mno=134239 [Access: November 08, 2024]. doi:10.4314/ovj.v11i1.6

AMA (American Medical Association) Style

Mancini SL, Early P, Munana K, Olby N, Mariani C, Pastina B, . The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. Open Vet J. 2021; 11(1): 36-38. doi:10.4314/ovj.v11i1.6


Vancouver/ICMJE Style

Mancini SL, Early P, Munana K, Olby N, Mariani C, Pastina B, . The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. Open Vet J. (2021), [cited November 08, 2024]; 11(1): 36-38. doi:10.4314/ovj.v11i1.6


Harvard Style

Mancini, S. L., Early, P., Munana, K., Olby, N., Mariani, C., Pastina, B. & (2021) The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. Open Vet J, 11 (1), 36-38. doi:10.4314/ovj.v11i1.6


Turabian Style

Mancini, Shelby L, Peter Early, Karen Munana, Natasha Olby, Christopher Mariani, Bethany Pastina, and . 2021. The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. Open Veterinary Journal, 11 (1), 36-38. doi:10.4314/ovj.v11i1.6


Chicago Style

Mancini, Shelby L, Peter Early, Karen Munana, Natasha Olby, Christopher Mariani, Bethany Pastina, and . "The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery." Open Veterinary Journal 11 (2021), 36-38. doi:10.4314/ovj.v11i1.6


MLA (The Modern Language Association) Style

Mancini, Shelby L, Peter Early, Karen Munana, Natasha Olby, Christopher Mariani, Bethany Pastina, and . "The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery." Open Veterinary Journal 11.1 (2021), 36-38. Print. doi:10.4314/ovj.v11i1.6


APA (American Psychological Association) Style

Mancini, S. L., Early, P., Munana, K., Olby, N., Mariani, C., Pastina, B. & (2021) The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. Open Veterinary Journal, 11 (1), 36-38. doi:10.4314/ovj.v11i1.6


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