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2025, Vol: 15, Issue: 2
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Short Communication


The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery

Shelby L Mancini, Peter Early, Karen Munana, Natasha Olby, Christopher Mariani, Bethany Pastina.


Cited By:1

Abstract
Background: Cytarabine (CA) is used to treat dogs with meningoencephalomyelitis of unknown etiology (MUE) by subcutaneous (SC) or intravenous (IV) administration.
Aim: The objective was to investigate transdermal iontophoresis and rectal administration as alternative routes of CA delivery.
Methods: Two client-owned dogs with MUE were studied. The ActivaPatch® IONTOGO™ 12.0 iontophoresis drug delivery system delivered 200 mg/m^2 CA transdermally. Blood samples were collected by sparse sampling technique after initiation of the device. At another visit, 100 mg/m^2 CA was administered rectally. Blood samples were collected by sparse sampling technique after administration. Plasma CA concentrations were measured by high-pressure liquid chromatography (HPLC).
Results: The concentration of plasma CA after transdermal and rectal administration was below the limits of quantification (0.1ug/mL) in all samples suggesting inadequate bioavailability with transdermal and rectal administration.
Conclusion: Transdermal and rectal CA administration are not reasonable alternative routes of delivery.

Key words: dog, meningoencephalitis, cytarabine, bioavailability


 
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How to Cite this Article
Pubmed Style

Mancini SL, Early P, Munana K, Olby N, Mariani C, Pastina B. The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. Open Vet J. 2021; 11(1): 36-38. doi:10.4314/ovj.v11i1.6

Web Style

Mancini SL, Early P, Munana K, Olby N, Mariani C, Pastina B. The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. https://www.openveterinaryjournal.com/?mno=134239 [Access: March 13, 2025]. doi:10.4314/ovj.v11i1.6

AMA (American Medical Association) Style

Mancini SL, Early P, Munana K, Olby N, Mariani C, Pastina B. The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. Open Vet J. 2021; 11(1): 36-38. doi:10.4314/ovj.v11i1.6


Vancouver/ICMJE Style

Mancini SL, Early P, Munana K, Olby N, Mariani C, Pastina B. The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. Open Vet J. (2021), [cited March 13, 2025]; 11(1): 36-38. doi:10.4314/ovj.v11i1.6


Harvard Style

Mancini, S. L., Early, . P., Munana, . K., Olby, . N., Mariani, . C. & Pastina, . B. (2021) The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. Open Vet J, 11 (1), 36-38. doi:10.4314/ovj.v11i1.6


Turabian Style

Mancini, Shelby L, Peter Early, Karen Munana, Natasha Olby, Christopher Mariani, and Bethany Pastina. 2021. The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. Open Veterinary Journal, 11 (1), 36-38. doi:10.4314/ovj.v11i1.6


Chicago Style

Mancini, Shelby L, Peter Early, Karen Munana, Natasha Olby, Christopher Mariani, and Bethany Pastina. "The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery." Open Veterinary Journal 11 (2021), 36-38. doi:10.4314/ovj.v11i1.6


MLA (The Modern Language Association) Style

Mancini, Shelby L, Peter Early, Karen Munana, Natasha Olby, Christopher Mariani, and Bethany Pastina. "The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery." Open Veterinary Journal 11.1 (2021), 36-38. Print. doi:10.4314/ovj.v11i1.6


APA (American Psychological Association) Style

Mancini, S. L., Early, . P., Munana, . K., Olby, . N., Mariani, . C. & Pastina, . B. (2021) The Bioavailability of Cytarabine in Dogs with Meningoencephalitis of Unknown Etiology through Iontophoresis and Rectal Delivery. Open Veterinary Journal, 11 (1), 36-38. doi:10.4314/ovj.v11i1.6


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