E-ISSN 2218-6050 | ISSN 2226-4485
 

Case Report


Efficacy and adverse events of anthracycline and propranolol combination in five dogs with stage 3 hemangiosarcoma

Mitsuhiko Terauchi, Yuji Fujii, Sho Goto, Ryota Iwasaki, Ryutaro Yoshikawa, Takashi Mori.


Abstract
Background:
Canine hemangiosarcoma (HSA), which originates from endothelial cells, is one of the most common malignant neoplasms that frequently develop metastatic lesions. Although anthracycline-based HSA treatment strategies have been widely investigated, reliable therapy for dogs with clinically advanced-stage HSA (stage 3 HSA) has not been established yet. Recently, several studies have demonstrated that propranolol, a beta-adrenergic receptor antagonist, exhibits anti-tumor effects against tumors originating from vascular endothelial cells, indicating the possibility that propranolol is a candidate adjunctive agent for anthracycline-based therapy in dogs with stage 3 HSA. This study aimed to evaluate the clinically efficacy and adverse events of anthracycline and propranolol combination in stage 3 HSA-affected dogs.
Case Description:
We retrospectively investigated 5 dogs diagnosed with stage 3 HSA which were administered with both anthracycline and propranolol during the same period between January 2020 and August 2021. Clinical benefit was observed in 4 of 5 HSA dogs (1 of complete response [CR], 1 of partial response [PR] and 2 of stable disease [SD]) with gross metastatic lesions by anthracycline and propranolol combination. Notably, some or all of the metastatic lesions were reduced in 2 cases. In all 5 dogs administered with anthracycline and propranolol combination, no serious and irreversible adverse effects were observed.
Conclusion:
Our findings demonstrate the efficacy and safety of anthracycline and propranolol combination in stage 3 HSA-affected dogs. Further studies are needed to establish treatment protocols based on anthracycline and propranolol combination for dogs with advanced HSA.

Key words: Hemangiosarcoma, Stage 3, Dog, Anthracycline, Propranolol


 
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How to Cite this Article
Pubmed Style

Terauchi M, Fujii Y, Goto S, Iwasaki R, Yoshikawa R, Mori T. Efficacy and adverse events of anthracycline and propranolol combination in five dogs with stage 3 hemangiosarcoma. Open Vet J. 2023; 13(6): 801-806. doi:10.5455/OVJ.2023.v13.i6.15


Web Style

Terauchi M, Fujii Y, Goto S, Iwasaki R, Yoshikawa R, Mori T. Efficacy and adverse events of anthracycline and propranolol combination in five dogs with stage 3 hemangiosarcoma. https://www.openveterinaryjournal.com/?mno=144688 [Access: April 10, 2024]. doi:10.5455/OVJ.2023.v13.i6.15


AMA (American Medical Association) Style

Terauchi M, Fujii Y, Goto S, Iwasaki R, Yoshikawa R, Mori T. Efficacy and adverse events of anthracycline and propranolol combination in five dogs with stage 3 hemangiosarcoma. Open Vet J. 2023; 13(6): 801-806. doi:10.5455/OVJ.2023.v13.i6.15



Vancouver/ICMJE Style

Terauchi M, Fujii Y, Goto S, Iwasaki R, Yoshikawa R, Mori T. Efficacy and adverse events of anthracycline and propranolol combination in five dogs with stage 3 hemangiosarcoma. Open Vet J. (2023), [cited April 10, 2024]; 13(6): 801-806. doi:10.5455/OVJ.2023.v13.i6.15



Harvard Style

Terauchi, M., Fujii, . Y., Goto, . S., Iwasaki, . R., Yoshikawa, . R. & Mori, . T. (2023) Efficacy and adverse events of anthracycline and propranolol combination in five dogs with stage 3 hemangiosarcoma. Open Vet J, 13 (6), 801-806. doi:10.5455/OVJ.2023.v13.i6.15



Turabian Style

Terauchi, Mitsuhiko, Yuji Fujii, Sho Goto, Ryota Iwasaki, Ryutaro Yoshikawa, and Takashi Mori. 2023. Efficacy and adverse events of anthracycline and propranolol combination in five dogs with stage 3 hemangiosarcoma. Open Veterinary Journal, 13 (6), 801-806. doi:10.5455/OVJ.2023.v13.i6.15



Chicago Style

Terauchi, Mitsuhiko, Yuji Fujii, Sho Goto, Ryota Iwasaki, Ryutaro Yoshikawa, and Takashi Mori. "Efficacy and adverse events of anthracycline and propranolol combination in five dogs with stage 3 hemangiosarcoma." Open Veterinary Journal 13 (2023), 801-806. doi:10.5455/OVJ.2023.v13.i6.15



MLA (The Modern Language Association) Style

Terauchi, Mitsuhiko, Yuji Fujii, Sho Goto, Ryota Iwasaki, Ryutaro Yoshikawa, and Takashi Mori. "Efficacy and adverse events of anthracycline and propranolol combination in five dogs with stage 3 hemangiosarcoma." Open Veterinary Journal 13.6 (2023), 801-806. Print. doi:10.5455/OVJ.2023.v13.i6.15



APA (American Psychological Association) Style

Terauchi, M., Fujii, . Y., Goto, . S., Iwasaki, . R., Yoshikawa, . R. & Mori, . T. (2023) Efficacy and adverse events of anthracycline and propranolol combination in five dogs with stage 3 hemangiosarcoma. Open Veterinary Journal, 13 (6), 801-806. doi:10.5455/OVJ.2023.v13.i6.15