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Research Article


Possible role of pomegranate fruit in reversing renal damage in rats exposed to Phenylhydrazine

Nabil Abbas Soliman, Sherif Wajih Mansour, Mohamed Ahmed Ammar, Noura Ahmed Hassan, Rehab Hamed Mohamed.


Abstract
Background:
Pomegranate granatum (molasses and peels) and its constituents showed protective effects against natural toxins such as phenylhydrazine as well as chemical toxicants as arsenic, diazinon, and carbon tetrachloride.
Aim:
The current study was aimed to assess the effect of pomegranate molasses, white peel extract; red peel extract on nephrotoxicity induced by Phenylhydrazine.
Methods:
80 male rats were divided to eight equal groups; a control group, pomegranate molasses pure group, White peel pomegranate pure group, red peel pomegranate pure group, Phenylhydrazine (PHZ) group, pomegranate molasses + Phenylhydrazine group, White peel pomegranate + Phenylhydrazine group and red peel pomegranate + Phenylhydrazine group. Kidney function, inflammation markers, antioxidant activities and renal tissues histopathology were investigated.
Results:
The results revealed that Phenylhydrazine group showed a significant increase in LDH, MDA, creatinine, uric Acid, blood urea nitrogen, C - reactive protein (CRP), Tumor Necrosis Factor, thiobarbituric acid reactive substances, and total antioxidant capacity with a significant decrease of CAT, GPx, and SOD as compared with Control group. Other pomegranate treated and PHZ co-treated groups with pomegranate showed significant decreasing of LDH, MDA, creatinine, uric Acid, blood urea nitrogen, tumor necrosis factor, thiobarbituric acid reactive substances and total antioxidant capacity with a significant increase of CAT, GPx, and SOD as compared with Phenylhydrazine group.
Conclusion:
Collectively our data suggest that red, white peels and molasses have anti-toxic and anti- inflammatory effect on renal function and tissues.

Key words: Peel pomegranate, Molasses, Phenylhydrazine, Thiobarbituric acid reactive substances, Total antioxidant capacity


 
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How to Cite this Article
Pubmed Style

Soliman NA, Mansour SW, Ammar MA, Hassan NA, Mohamed RH. Possible role of pomegranate fruit in reversing renal damage in rats exposed to Phenylhydrazine. Open Vet J. 2023; 13(10): 1268-1276. doi:10.5455/OVJ.2023.v13.i10.5


Web Style

Soliman NA, Mansour SW, Ammar MA, Hassan NA, Mohamed RH. Possible role of pomegranate fruit in reversing renal damage in rats exposed to Phenylhydrazine. https://www.openveterinaryjournal.com/?mno=159167 [Access: April 10, 2024]. doi:10.5455/OVJ.2023.v13.i10.5


AMA (American Medical Association) Style

Soliman NA, Mansour SW, Ammar MA, Hassan NA, Mohamed RH. Possible role of pomegranate fruit in reversing renal damage in rats exposed to Phenylhydrazine. Open Vet J. 2023; 13(10): 1268-1276. doi:10.5455/OVJ.2023.v13.i10.5



Vancouver/ICMJE Style

Soliman NA, Mansour SW, Ammar MA, Hassan NA, Mohamed RH. Possible role of pomegranate fruit in reversing renal damage in rats exposed to Phenylhydrazine. Open Vet J. (2023), [cited April 10, 2024]; 13(10): 1268-1276. doi:10.5455/OVJ.2023.v13.i10.5



Harvard Style

Soliman, N. A., Mansour, . S. W., Ammar, . M. A., Hassan, . N. A. & Mohamed, . R. H. (2023) Possible role of pomegranate fruit in reversing renal damage in rats exposed to Phenylhydrazine. Open Vet J, 13 (10), 1268-1276. doi:10.5455/OVJ.2023.v13.i10.5



Turabian Style

Soliman, Nabil Abbas, Sherif Wajih Mansour, Mohamed Ahmed Ammar, Noura Ahmed Hassan, and Rehab Hamed Mohamed. 2023. Possible role of pomegranate fruit in reversing renal damage in rats exposed to Phenylhydrazine. Open Veterinary Journal, 13 (10), 1268-1276. doi:10.5455/OVJ.2023.v13.i10.5



Chicago Style

Soliman, Nabil Abbas, Sherif Wajih Mansour, Mohamed Ahmed Ammar, Noura Ahmed Hassan, and Rehab Hamed Mohamed. "Possible role of pomegranate fruit in reversing renal damage in rats exposed to Phenylhydrazine." Open Veterinary Journal 13 (2023), 1268-1276. doi:10.5455/OVJ.2023.v13.i10.5



MLA (The Modern Language Association) Style

Soliman, Nabil Abbas, Sherif Wajih Mansour, Mohamed Ahmed Ammar, Noura Ahmed Hassan, and Rehab Hamed Mohamed. "Possible role of pomegranate fruit in reversing renal damage in rats exposed to Phenylhydrazine." Open Veterinary Journal 13.10 (2023), 1268-1276. Print. doi:10.5455/OVJ.2023.v13.i10.5



APA (American Psychological Association) Style

Soliman, N. A., Mansour, . S. W., Ammar, . M. A., Hassan, . N. A. & Mohamed, . R. H. (2023) Possible role of pomegranate fruit in reversing renal damage in rats exposed to Phenylhydrazine. Open Veterinary Journal, 13 (10), 1268-1276. doi:10.5455/OVJ.2023.v13.i10.5