E-ISSN 2218-6050 | ISSN 2226-4485
 

Research Article


Ameliorative effect of transfersome gel of kepok banana peel extract (Musa balbisiana) against photoaging in Wistar rat skin

Elly Mayangsari, Arifa Mustika, Nurdiana Nurdiana, Nozlena Abdul Samad.


Abstract
Background:
Repeated acute exposure to UVB rays can cause photoaging. Musa balbisiana peel contains flavonoid compounds which act as antioxidants. But, the physicochemical of flavonoids are unstable, high molecular weight and easily oxidized, causing its use is still limited and transdermal delivery to be inefficient.
Aim:
To investigate the ameliorative effect of transfersome gel of Musa balbisiana peel against photoaging in Wistar rat skin.
Methods:
Transfersome gel was characterized by TEM. In vivo research was used to determine ameliorative effects of Musa balbisiana peel. The composition of transfersome consist of ethanol extracts of Musa balbisiana peel, SPC, and tween 80. The gel was applied three times a week for four weeks with a total UVB radiation dose of 840 mJ/cm2. To evaluate the repair mechanism by measuring the degree of wrinkles, epidermal thickening, dermal thinning, collagen fiber irregularity, matrix metalloproteinase 1 and TGF-β expression, MDA and TNFα levels.
Results:
TEM results show that gel transfersome Musa balbisiana peel has a round morphology with a diameter of ± 50 nm and no aggregation, which are defined as nanoparticles. Transfersome gel ameliorated degree of wrinkle, epidermal thickening, dermal thinning and irregularity of collagen fibers caused by UVB exposure, suppresses lipid peroxidation by decreasing MDA and TNFα level, also collagen imbalance by inhibiting MMP-1 expression and activating TGF-β expression, which were found statistically significantly different from non transfersome gel group.
Conclusion:
Transfersome gel of Musa balbisiana peel can act as an alternative medicine to ameliorate clinical photoaging due to exposure UVB.

Key words: Medicine, Musa balbisiana peel, Photoaging, Transfersome gel, Ultraviolet B radiation


 
ARTICLE TOOLS
Abstract
PDF Fulltext
HTML Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Elly Mayangsari
Articles by Arifa Mustika
Articles by Nurdiana Nurdiana
Articles by Nozlena Abdul Samad
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Mayangsari E, Mustika A, Nurdiana N, Samad NA. Ameliorative effect of transfersome gel of kepok banana peel extract (Musa balbisiana) against photoaging in Wistar rat skin. Open Vet J. 2024; 14(8): 1990-1998. doi:10.5455/OVJ.2024.v14.i8.28


Web Style

Mayangsari E, Mustika A, Nurdiana N, Samad NA. Ameliorative effect of transfersome gel of kepok banana peel extract (Musa balbisiana) against photoaging in Wistar rat skin. https://www.openveterinaryjournal.com/?mno=202227 [Access: October 10, 2024]. doi:10.5455/OVJ.2024.v14.i8.28


AMA (American Medical Association) Style

Mayangsari E, Mustika A, Nurdiana N, Samad NA. Ameliorative effect of transfersome gel of kepok banana peel extract (Musa balbisiana) against photoaging in Wistar rat skin. Open Vet J. 2024; 14(8): 1990-1998. doi:10.5455/OVJ.2024.v14.i8.28



Vancouver/ICMJE Style

Mayangsari E, Mustika A, Nurdiana N, Samad NA. Ameliorative effect of transfersome gel of kepok banana peel extract (Musa balbisiana) against photoaging in Wistar rat skin. Open Vet J. (2024), [cited October 10, 2024]; 14(8): 1990-1998. doi:10.5455/OVJ.2024.v14.i8.28



Harvard Style

Mayangsari, E., Mustika, . A., Nurdiana, . N. & Samad, . N. A. (2024) Ameliorative effect of transfersome gel of kepok banana peel extract (Musa balbisiana) against photoaging in Wistar rat skin. Open Vet J, 14 (8), 1990-1998. doi:10.5455/OVJ.2024.v14.i8.28



Turabian Style

Mayangsari, Elly, Arifa Mustika, Nurdiana Nurdiana, and Nozlena Abdul Samad. 2024. Ameliorative effect of transfersome gel of kepok banana peel extract (Musa balbisiana) against photoaging in Wistar rat skin. Open Veterinary Journal, 14 (8), 1990-1998. doi:10.5455/OVJ.2024.v14.i8.28



Chicago Style

Mayangsari, Elly, Arifa Mustika, Nurdiana Nurdiana, and Nozlena Abdul Samad. "Ameliorative effect of transfersome gel of kepok banana peel extract (Musa balbisiana) against photoaging in Wistar rat skin." Open Veterinary Journal 14 (2024), 1990-1998. doi:10.5455/OVJ.2024.v14.i8.28



MLA (The Modern Language Association) Style

Mayangsari, Elly, Arifa Mustika, Nurdiana Nurdiana, and Nozlena Abdul Samad. "Ameliorative effect of transfersome gel of kepok banana peel extract (Musa balbisiana) against photoaging in Wistar rat skin." Open Veterinary Journal 14.8 (2024), 1990-1998. Print. doi:10.5455/OVJ.2024.v14.i8.28



APA (American Psychological Association) Style

Mayangsari, E., Mustika, . A., Nurdiana, . N. & Samad, . N. A. (2024) Ameliorative effect of transfersome gel of kepok banana peel extract (Musa balbisiana) against photoaging in Wistar rat skin. Open Veterinary Journal, 14 (8), 1990-1998. doi:10.5455/OVJ.2024.v14.i8.28