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Research Article


Antimalarial activity of borrelidin and fumagilin in Plasmodium berghei-infected mice

Risqa Novita, Agik Suprayogi, Andria Agusta, Arifin Budiman Nugraha, Tomoyoshi Nozaki, Kurnia Agustini, Huda Shalahudin Darusman.


Abstract
Background:
Malaria remains a significant global health burden, with drug resistance posing a major challenge to its control. The emergence of resistance to antimalarial drugs represents a critical issue in malaria management, as it heightens the likelihood of morbidity and mortality associated with the disease. There is an urgent requirement for a novel candidate drug with a distinct mechanism of action.
Aim:
In light of the ongoing challenges in malaria management, particularly the emergence of drug resistance, this study aimed to investigate the efficacy of a novel combination therapy of borrelidin and fumagilin against Plasmodium berghei infection on Swiss Webster mice. The findings of this study could contribute to developing new and effective antimalarial treatments.
Methods:
This study employed a unique approach, using Swiss Webster mice aged 6 to 8 weeks and dividing them into five groups, each with five mice. The therapeutic efficacy of the combination treatment was evaluated through a comprehensive assessment of parasitemia levels, survival rates, and histological changes in the liver and spleen. This rigorous methodology ensures the reliability and validity of our findings.
Results:
The combination of borrelidin and fumagilin led to the lowest parasitemia at 5%, contrasting with the control group reaching 15%. Moreover, the combination group exhibited the highest inhibition rate of 69.6% on day nine post-infection. Histopathological alterations were limited to sinusoid dilation, hepatocyte ballooning, and the presence of hemozoin.
Conclusion:
These findings suggest that the combination of borrelidin and fumagilin holds promise as a potential antimalarial therapy.

Key words: Antibiotic, Drug resistance, Malaria, SDG’s


 
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How to Cite this Article
Pubmed Style

Novita R, Suprayogi A, Agusta A, Nugraha AB, Nozaki T, Agustini K, Darusman HS. Antimalarial activity of borrelidin and fumagilin in Plasmodium berghei-infected mice. Open Vet J. 2024; 14(8): 2007-2015. doi:10.5455/OVJ.2024.v14.i8.30

Web Style

Novita R, Suprayogi A, Agusta A, Nugraha AB, Nozaki T, Agustini K, Darusman HS. Antimalarial activity of borrelidin and fumagilin in Plasmodium berghei-infected mice. https://www.openveterinaryjournal.com/?mno=203896 [Access: November 07, 2024]. doi:10.5455/OVJ.2024.v14.i8.30

AMA (American Medical Association) Style

Novita R, Suprayogi A, Agusta A, Nugraha AB, Nozaki T, Agustini K, Darusman HS. Antimalarial activity of borrelidin and fumagilin in Plasmodium berghei-infected mice. Open Vet J. 2024; 14(8): 2007-2015. doi:10.5455/OVJ.2024.v14.i8.30


Vancouver/ICMJE Style

Novita R, Suprayogi A, Agusta A, Nugraha AB, Nozaki T, Agustini K, Darusman HS. Antimalarial activity of borrelidin and fumagilin in Plasmodium berghei-infected mice. Open Vet J. (2024), [cited November 07, 2024]; 14(8): 2007-2015. doi:10.5455/OVJ.2024.v14.i8.30


Harvard Style

Novita, R., Suprayogi, . A., Agusta, . A., Nugraha, . A. B., Nozaki, . T., Agustini, . K. & Darusman, . H. S. (2024) Antimalarial activity of borrelidin and fumagilin in Plasmodium berghei-infected mice. Open Vet J, 14 (8), 2007-2015. doi:10.5455/OVJ.2024.v14.i8.30


Turabian Style

Novita, Risqa, Agik Suprayogi, Andria Agusta, Arifin Budiman Nugraha, Tomoyoshi Nozaki, Kurnia Agustini, and Huda Shalahudin Darusman. 2024. Antimalarial activity of borrelidin and fumagilin in Plasmodium berghei-infected mice. Open Veterinary Journal, 14 (8), 2007-2015. doi:10.5455/OVJ.2024.v14.i8.30


Chicago Style

Novita, Risqa, Agik Suprayogi, Andria Agusta, Arifin Budiman Nugraha, Tomoyoshi Nozaki, Kurnia Agustini, and Huda Shalahudin Darusman. "Antimalarial activity of borrelidin and fumagilin in Plasmodium berghei-infected mice." Open Veterinary Journal 14 (2024), 2007-2015. doi:10.5455/OVJ.2024.v14.i8.30


MLA (The Modern Language Association) Style

Novita, Risqa, Agik Suprayogi, Andria Agusta, Arifin Budiman Nugraha, Tomoyoshi Nozaki, Kurnia Agustini, and Huda Shalahudin Darusman. "Antimalarial activity of borrelidin and fumagilin in Plasmodium berghei-infected mice." Open Veterinary Journal 14.8 (2024), 2007-2015. Print. doi:10.5455/OVJ.2024.v14.i8.30


APA (American Psychological Association) Style

Novita, R., Suprayogi, . A., Agusta, . A., Nugraha, . A. B., Nozaki, . T., Agustini, . K. & Darusman, . H. S. (2024) Antimalarial activity of borrelidin and fumagilin in Plasmodium berghei-infected mice. Open Veterinary Journal, 14 (8), 2007-2015. doi:10.5455/OVJ.2024.v14.i8.30


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