Abstract
Background:
Stress can cause an increase in proinflammatory cytokines, IL-6, which plays a role in the inflammatory response and causes changes in the placenta, causing a low risk of the fetus being born. Giving nanocurcumin, which functions as an anti-inflammatory and antioxidant, is expected to reduce cortisol levels which increase during pregnancy.

Aim:
This study aims to determine the effect of stress during pregnancy on pregnant mice, namely IL-6 expression and fetal body weight.

Methods:
This study used 25 mice that were given 5 treatment groups, K(-) with no treatment, K(+) with an induced disturbance of 135 dB for 40 minutes with a continuous pattern, P1, P2, and P3 were given a disturbance of 135 dB for 40 minutes. with a continuous pattern and nanocurcumin doses of 14 mg/kg BW, 21 mg/kgBW, 24.5 mg/kgBW. IL-6 expression in placental organs was measured using immunohistochemistry and fetal body weight was weighed using a digital balance. Data analyzed using the Kruskal Wallis test and continued with the Parwise Comparison test.

Results:
The results of analysis of IL-6 expression in the placenta showed no significant difference in the P3 group compared to the negative control group. The results of fetal weight analysis showed no significant difference in groups P2 and P3 with the negative control group.

Conclusion:
The conclusion of this study is the administration of nanocurcumin in group P3 has been proven to increase IL-6 to a level comparable to the negative control group (p<0.05). Similarly, the administration of nanocurcumin in groups P2 and P3 can increase fetal weight to a level comparable to the negative control group (p<0.05)

Key words: Stress, Cortisol, Nanocurcumin, Pregnant mice, IL-6