E-ISSN 2218-6050 | ISSN 2226-4485
 
2023, Vol: 13, Issue: 3
13/3Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

OVJ Manuscript Submission Form

Case Report


Histological and virological findings in severe meningoencephalitis associated with Border Disease virus in Alpine chamois (Rupicapra rupicapra rupicapra) in Aosta Valley, Italy

Massimo Giangaspero, Lorenzo Domenis, Serena Robetto, Riccardo Orusa.

Cited By:1

Abstract
In 2015, a young female Alpine chamois (Rupicapra rupicapra rupicapra), originated from the Aosta Valley Region, Northernwestern Italy, was conferred to the National Reference Center for Wild Animal Diseases for pathologic examinations. Histological analysis revealed a severe meningoencephalitis characterized by lymphocytic and plasmacellular infiltration, gliosis, perivascular cuffs and leptomeningitis at the level of brain and brain stem. Laboratory investigations included polymerase chain reaction, sequencing and characterization by phylogenetic analysis and evaluation of the internal ribosome entry site (IRES) secondary structure in the 5’ untranslated region. These tests identified the pathological agent as Border Disease virus (BDV), a known health risk in domestic small ruminants. Genetic characteristics of the isolated strains, closely related to ovine and caprine strain sequences from neighbouring regions of Piedmont, France and Switzerland, suggested geographic segregation and micro-evolutive steps within the species.

Key words: Alpine chamois, Border Disease virus, Meningoencephalitis, Pestivirus, Rupicapra rupicapra rupicapra.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Massimo Giangaspero
Articles by Lorenzo Domenis
Articles by Serena Robetto
Articles by Riccardo Orusa
on Google
on Google Scholar


REFERENCES
1. Lopez AD, Murray CC. The global burden of disease, 1990–2020. Nat Med 1998; 4(11):1241-3. [DOI via Crossref]    [Pubmed]   
2. Murray CJ, Lopez AD. Evidence-based health policy: lessons from the Global Burden of Disease Study. Science 1996; 6:1593-4.
3. Ries AL, Kaplan RM, Limberg TM, Prewitt LM. Effects of pulmonary rehabilitation on physiologic and psychosocial outcomes in patients with chronic obstructive pulmonary disease. Ann Intern Med 1995; 122(11):823–832.
4. Sala E, Roca J, Marrades RM, Alonso J, Gonzalez DeSuso JM, Moreno A, Barberá JA, Nadal J, de JoverL, Rodriguez-Roisin R, Wagner PD. Effects of endurance training on skeletal muscle bioenergetics in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999;159:1726–1734.
5. Imen Ben Cheikh Rejbi, Yassine Trabelsi, AfefChouchene, Wafa Ben Turkia, Helmi BenSaad, Abdelkarim Zbidi, AbdelhamidKerken, and Zouhair Tabka. Changes in six-minute walking distance during pulmonary rehabilitation in patients with COPD and in healthy subjects. Int J Chron Obstruct Pulmon Dis 2010; 9 (5):209-15. [DOI via Crossref]   
6. Satta A, Migliori GB, Spanevello A, Neri M, BottinelliR, Canepari M, Pellegrino MA, Reggiani C. Fiber types in skeletal muscles of chronic obstructive pulmonary disease patients related to respiratory function and exercise tolerance. Eur Respir J 1997; 10:2853–2860.
7. Reid MB : COPD as a muscle disease. Am J Respir Crit Care Med 2001;164 : 1101-5 [DOI via Crossref]    [Pubmed]   
8. Marquis K, Debigaré R, Lacasse Y, LeBlanc P, JobinJ, Carrier G, Maltais F. Midthigh muscle crosssectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002 ; 166 : 809-13. [DOI via Crossref]    [Pubmed]   
9. Decramer M, Gosselink R, Troosters T, Verschueren M, Evers G : Muscle weakness is related to utilization of health care resources in COPD patients. Eur Respir J 1997 ; 10 : 417-23. [DOI via Crossref]   
10. Steiner MC, Barton RL, Singh SJ, Morgan MD. Nutritional enhancement of exercise performance in chronic obstructive pulmonary disease: a randomised controlled trial. Thorax 2003;58(9):745-51. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
11. Laghi F, Adiguzel N, Tobin MJ. Endocrinological derangements in COPD. Eur Respir J 2009; 34(4):975-96. [DOI via Crossref]    [Pubmed]   
12. Van Vliet M, Spruit MA, Verleden G, Kasran A, VanHerck E, Pitta F, Bouillon R, Decramer M.Hypogonadism, quadriceps weakness, and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005; 172(9):1105-11. [DOI via Crossref]    [Pubmed]   
13. Durand F, Delample D, Poulain M, Préfaut C. Incidence of individualized training on exerciseinduced desaturation in COPD patients. Rev Mal Respir 2007; 24(5):591-8. [DOI via Crossref]   
14. Mandigout S, Antonini MT, Laforge Q, Lemaire F, Dalmay F, Bouteille B. Contribution à l’étude des effets d’un programme de réentraînement à l’effort sur les aptitudes physiques de patients atteints de bronchopneumopathie chronique obstructive. Science & Sports 2007; 22(6): 300-301. [DOI via Crossref]   
15. Porszasz J, Emtner M, Goto S, Somfay A, Whipp BJ, Casaburi R. Exercise training decreases ventilatory requirements and exercise-induced hyperinflation at submaximal intensities in patients with COPD. Chest 2005 ; 128(4):2025-34. [DOI via Crossref]    [Pubmed]   
16. Drozdowski J, Bakuła S, Drozdowska A, Kedziora K, Porzezioska M, Słomioski JM. The effects of pulmonary rehabilitation on the quality of life in patients with COPD. Pneumonol Alergol Pol. 2007;75(2):147-52.
17. Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J 1994; 7(6):1197-8.
18. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002; 166:111–117.
19. Ben Saad H, Prefaut C, Tabka Z, Mtir AH, ChemitM, Hassaoune R, Ben Abid T, Zara K, Mercier G, ZbidiA, Hayot M. 6-minute walk distance in healthy North Africans older than 40 years: influence of parity. Respir Med 2009;103(1):74–84
20. Vallet G, Ahmaïdi S, Serres I, Fabre C, BourgouinD, Desplan J, Varray A, Préfaut C. Comparison of two training programmes in chronic airway limitation patients: standardized versus individualized protocols. Eur Respir J 1997; 10(1):114-22. [DOI via Crossref]    [Pubmed]   
21. Derom E, Marchand E, Troosters T, Réhabilitation du malade atteint de bronchopneumopathie chronique obstructive . Annales de Réadaptation et de Médecine Physique 2007; 50(7):602-614. [DOI via Crossref]   
22. Zwick RH, Burghuber OC, Dovjak N, Hartl S, Kossler W, Lichtenschopf A, Muller R, Zwick H. The effect of one year outpatient pulmonary rehabilitation on patients with COPD. Wien Klin Wochenschr. 2009; 121(5-6):189-95.
23. Vallet G, Ahmaidi S, Serres I, et al. Comparison of two training programmes in chronic airway limitation patients: standardized versus individualized protocols. Eur Respir J 1997;10:114–122.
24. Casaburi R, Patessio A, Ioli F, Zanaboni S, DonnerCF, Wasserman K. Reductions in exercise lactic acidosis and ventilation as a result of exercise training in patients with obstructive lung disease. Am Rev Respir Dis 1991; 143:9–18.
25. Scalvini S, Volterrani M, Vitacca M, Clark AL, SolfriniR, Panzali AM, Ferrari R, Levi GF. Plasma hormone levels and haemodynamics in patients with chronic obstructive lung disease. Monaldi Arch Chest Dis. 1996; 51(5):380-6.
26. Crul T, Spruit MA, Gayan-Ramirez G, Quarck R, Gosselink R, Troosters T, Pitta F, Decramer M.Markers of inflammation and disuse in vastus lateralis of chronic obstructive pulmonary disease patients. Eur J Clin Invest 2007; 37(11):897-904. [DOI via Crossref]    [Pubmed]   
27. Sacheck JM, Ohtsuka A, McLary SC, Goldberg AL. IGFI stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1. Am J Physiol Endocrinol Metab. 2004; 287(4):E591-601.
28. Lafranco F, Gianotti L, Giordano R, Pellegrino M, Maccario M, Arvat E. Aging, growth hormone and physical performance. J endocrinol Invest 2003; 26(9): 861-72. [DOI via Crossref]   
29. Koziris LP, Hickson RC, Chatterton RT Jr, GrosethRT, Christie JM, Goldflies DG, Unterman TG. Serum levels of total and free IGF-I and IGFBP-3 are increased and maintained in long-term training. J Appl Physiol 1999; 86(4):1436-42.
30. Manetta J, Brun JF, Maimoun L, Callis A, Préfaut C, Mercier J. Effect of training on the GH/IGF-I axis during exercise in middle-aged men: relationship to glucose homeostasis. Am J Physiol Endocrinol Metab 2002; 283(5):E929-36.
31. Singh MA, Ding W, Manfredi TJ, Solares GS, O'NeillEF, Clements KM, Ryan ND, Kehayias JJ, FieldingRA, Evans WJ. Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders. Am J Physio 1999; 277: 135-43.
32. Whittom F, Jobin J, Simard PM, Leblanc P, SimardC, Bernard S, Belleau R, Maltais F. Histochemical and morphological characteristics of the vastus lateralis muscle in patients with chronic obstructive pulmonary disease. Med Sci Sports Exerc 1998; 30(10):1467-74. [DOI via Crossref]    [Pubmed]   
33. Craig BW, Brown R, Everhart J. Effects of progressive resistance training on growth hormone and testosterone levels in young and elderly subjects. Mech Ageing Dev 1989; 49(2):159-69. [DOI via Crossref]   
34. Debigaré R, Marquis K, Côté CH, TremblayRR, Michaud A, LeBlanc P, Maltais F. Catabolic/anabolic balance and muscle wasting in patients with COPD. Chest 2003; 124(1):83-9. [DOI via Crossref]    [Pubmed]   
35. Kamischke A, Kemper DE, Castel MA, Luthke M, Rolf C, Behre HM, Magnussen H, Nieschlag E. Testosterone levels in men with chronic obstructive pulmonary disease with or without glucocorticoid therapy. Eur Respir J. 1998; 11(1):41-5. [DOI via Crossref]    [Pubmed]   
36. Creutzberg EC, Casaburi R. Endocrinological disturbances in chronic obstructive pulmonary disease. Eur Respir J Suppl 2003; 46:76-80 [DOI via Crossref]   
37. Herbst KL, Bhasin S. Testosterone action on skeletal muscle. Curr Opin Clin Nutr Metab Care 2004;7(3):271-7. Review.
38. Semple PD, Beastall GH, Watson WS, Hume R. Hypothalamic-pituitary dysfunction in respiratory hypoxia. Thorax. 1981; 36(8):605-9. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
39. Gosney JR. Atrophy of Leydig cells in the testes of men with long standing chronic bronchitis and emphysema. Thorax. 1987; 42(8):615-9. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
40. Schoorlemmer RM, Peeters GM, van Schoor NM, Lips P. Relationship between cortisol level, mortality and chronic diseases in older persons. Clin Endocrinol (Oxf). 2009; 71(6):779-86 [DOI via Crossref]    [Pubmed]   
41. Busso T, Häkkinen K, Pakarinen A, Carasso C, LacourJR, Komi PV, Kauhanen H. A systems model of training responses and its relationship to hormonal responses in elite weight-lifters. Eur J Appl Physiol Occup Physiol 1990;61(1-2):48-54.
42. Kraemer WJ, Häkkinen K, Newton RU, McCormickM, Nindl BC, Volek JS, Gotshalk LA, FleckSJ, Campbell WW, Gordon SE, Farrell PA, Evans WJ.Acute hormonal responses to heavy resistance exercise in younger and older men. Eur J Appl Physiol Occup Physiol 1998; 77(3):206-11. [DOI via Crossref]    [Pubmed]   
43. Schwab R, Johnson GO, Housh TJ, Kinder JE, Weir JP: Acute effects of different intensities of weight lifting on serum testosterone. Med Sci Sports Exerc 1993; 25(12):1381-5.
44. Kraemer WJ, Patton JF, Gordon SE, Harman EA,Deschenes MR, Reynolds K, Newton RU, Triplett NT, Dziados JE. Compatibility of high intensity strength and endurance training on hormonal and skeletal muscle adaptations. J Appl Physiol .1995;78:976-89.
45. Alén M, Pakarinen A, Häkkinen K, Komi PV. Responses of serum androgenic-anabolic and catabolic hormones to prolonged strength training. Int J Sports Med 1988; 9(3):229-33. [DOI via Crossref]    [Pubmed]   
46. Häkkinen K, Pakarinen A. Serum hormones and strength development during strength training in middle-aged and elderly males and females. Acta Physiol Scand 1994; 150(2):211-9. [DOI via Crossref]    [Pubmed]   
47. Urban RJ, Bodenburg YH, Gilkison C, FoxworthJ, Coggan AR, Wolfe RR, Ferrando A. Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis. Am J Physiol. 1995; 269:820-6.

How to Cite this Article
Pubmed Style

Giangaspero M, Domenis L, Robetto S, Orusa R, . Histological and virological findings in severe meningoencephalitis associated with Border Disease virus in Alpine chamois (Rupicapra rupicapra rupicapra) in Aosta Valley, Italy . Open Vet J. 2019; 9(1): 81-87. doi:10.4314/ovj.v9i1.14

Web Style

Giangaspero M, Domenis L, Robetto S, Orusa R, . Histological and virological findings in severe meningoencephalitis associated with Border Disease virus in Alpine chamois (Rupicapra rupicapra rupicapra) in Aosta Valley, Italy . https://www.openveterinaryjournal.com/?mno=22594 [Access: March 29, 2023]. doi:10.4314/ovj.v9i1.14

AMA (American Medical Association) Style

Giangaspero M, Domenis L, Robetto S, Orusa R, . Histological and virological findings in severe meningoencephalitis associated with Border Disease virus in Alpine chamois (Rupicapra rupicapra rupicapra) in Aosta Valley, Italy . Open Vet J. 2019; 9(1): 81-87. doi:10.4314/ovj.v9i1.14


Vancouver/ICMJE Style

Giangaspero M, Domenis L, Robetto S, Orusa R, . Histological and virological findings in severe meningoencephalitis associated with Border Disease virus in Alpine chamois (Rupicapra rupicapra rupicapra) in Aosta Valley, Italy . Open Vet J. (2019), [cited March 29, 2023]; 9(1): 81-87. doi:10.4314/ovj.v9i1.14


Harvard Style

Giangaspero, M. ., Domenis, L. ., Robetto, S. ., Orusa, R. . & (2019) Histological and virological findings in severe meningoencephalitis associated with Border Disease virus in Alpine chamois (Rupicapra rupicapra rupicapra) in Aosta Valley, Italy . Open Vet J, 9 (1), 81-87. doi:10.4314/ovj.v9i1.14


Turabian Style

Giangaspero, Massimo , Lorenzo Domenis, Serena Robetto, Riccardo Orusa, and . 2019. Histological and virological findings in severe meningoencephalitis associated with Border Disease virus in Alpine chamois (Rupicapra rupicapra rupicapra) in Aosta Valley, Italy . Open Veterinary Journal, 9 (1), 81-87. doi:10.4314/ovj.v9i1.14


Chicago Style

Giangaspero, Massimo , Lorenzo Domenis, Serena Robetto, Riccardo Orusa, and . "Histological and virological findings in severe meningoencephalitis associated with Border Disease virus in Alpine chamois (Rupicapra rupicapra rupicapra) in Aosta Valley, Italy ." Open Veterinary Journal 9 (2019), 81-87. doi:10.4314/ovj.v9i1.14


MLA (The Modern Language Association) Style

Giangaspero, Massimo , Lorenzo Domenis, Serena Robetto, Riccardo Orusa, and . "Histological and virological findings in severe meningoencephalitis associated with Border Disease virus in Alpine chamois (Rupicapra rupicapra rupicapra) in Aosta Valley, Italy ." Open Veterinary Journal 9.1 (2019), 81-87. Print. doi:10.4314/ovj.v9i1.14


APA (American Psychological Association) Style

Giangaspero, M. ., Domenis, L. ., Robetto, S. ., Orusa, R. . & (2019) Histological and virological findings in severe meningoencephalitis associated with Border Disease virus in Alpine chamois (Rupicapra rupicapra rupicapra) in Aosta Valley, Italy . Open Veterinary Journal, 9 (1), 81-87. doi:10.4314/ovj.v9i1.14


Author LoginReviewer LoginAbout PublisherPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyTerms of UseLicense Information
This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access.
The articles in Open Veterinary Journal are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Copyright © 2023 Open Veterinary Journal All Rights Reserved. Subject to change without notice from or liability to Open Veterinary Journal.
For best results, please use Internet Explorer or Google Chrome

Contact Information


All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes: Owner, Founder and Editor-in-Chief

Open Veterinary Journal

Faculty of Veterinary Medicine

University of Tripoli

P.O. Box 13662, Tripoli, Libya