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Research Article


TGF-β from mesenchymal stem cell secretome improves sepsis score in murine model

Mutiara Indah Sari, Nelva Karmila Jusuf, Delfitri Munir, Agung Putra, Tatang Bisri, Syafruddin Ilyas, Farhat Farhat, Adi Muradi Muhar.


Abstract
Background:
Sepsis remains the main cause of morbidity and mortality worldwide. Early administration of appropriate antimicrobials is one of the most effective interventions for sepsis; however, antibiotic resistance in bacteria is growing continuously. Therefore, new complementary therapies are needed to treat sepsis. One of the recently studied complementary therapies is the administration of the mesenchymal stem cell (MSC) secretome. Several studies have shown that the secretome exerts immunomodulatory and antiinflammatory effects. However, the studies did not assess the clinical changes occurring in sepsis-induced rats.

Aim:
This study aimed to analyze the effect of TGF-β from the MSC secretome on sepsis scores in a murine model.

Methods:
Forty-eight rats were divided into 4 groups: healthy rats (rats without sepsis induction and therapy), control (300 µL saline + antibiotic), T1 (150 µL TGF-β from MSC secretome + antibiotic), and T2 (300 µL TGF-β from MSC secretome + antibiotic). The murine sepsis score (MSS) was observed every 6 hours for 48 hours. Data analysis was conducted using SPSS to examine the relationship between the effect of TGF-β from MSC secretome administration and the total mean of MSS. The value of p < 0.05 was considered significant.

Results:
Administering 150 µL of TGF-β from MSC secretome reduced the total mean MSS compared with the control group at the 42nd hour of observation (p = 0.017).

Conclusion:
Our research found that TGF-β from MSC secretome improved the sepsis score in sepsis-induced rats.

Key words: Mesenchymal stem cell; Murine sepsis score; TGF-β; Umbilical cord.


 
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How to Cite this Article
Pubmed Style

Sari MI, Jusuf NK, Munir D, Putra A, Bisri T, Ilyas S, Farhat F, Muhar AM. TGF-β from mesenchymal stem cell secretome improves sepsis score in murine model. Open Vet. J.. 2026; 16(7): 4274-4281. doi:10.5455/OVJ.2026.v16.i7.14

Web Style

Sari MI, Jusuf NK, Munir D, Putra A, Bisri T, Ilyas S, Farhat F, Muhar AM. TGF-β from mesenchymal stem cell secretome improves sepsis score in murine model. https://www.openveterinaryjournal.com/?mno=283198 [Access: June 30, 2026]. doi:10.5455/OVJ.2026.v16.i7.14

AMA (American Medical Association) Style

Sari MI, Jusuf NK, Munir D, Putra A, Bisri T, Ilyas S, Farhat F, Muhar AM. TGF-β from mesenchymal stem cell secretome improves sepsis score in murine model. Open Vet. J.. 2026; 16(7): 4274-4281. doi:10.5455/OVJ.2026.v16.i7.14


Vancouver/ICMJE Style

Sari MI, Jusuf NK, Munir D, Putra A, Bisri T, Ilyas S, Farhat F, Muhar AM. TGF-β from mesenchymal stem cell secretome improves sepsis score in murine model. Open Vet. J.. (2026), [cited June 30, 2026]; 16(7): 4274-4281. doi:10.5455/OVJ.2026.v16.i7.14


Harvard Style

Sari, M. I., Jusuf, . N. K., Munir, . D., Putra, . A., Bisri, . T., Ilyas, . S., Farhat, . F. & Muhar, . A. M. (2026) TGF-β from mesenchymal stem cell secretome improves sepsis score in murine model. Open Vet. J., 16 (7), 4274-4281. doi:10.5455/OVJ.2026.v16.i7.14


Turabian Style

Sari, Mutiara Indah, Nelva Karmila Jusuf, Delfitri Munir, Agung Putra, Tatang Bisri, Syafruddin Ilyas, Farhat Farhat, and Adi Muradi Muhar. 2026. TGF-β from mesenchymal stem cell secretome improves sepsis score in murine model. Open Veterinary Journal, 16 (7), 4274-4281. doi:10.5455/OVJ.2026.v16.i7.14


Chicago Style

Sari, Mutiara Indah, Nelva Karmila Jusuf, Delfitri Munir, Agung Putra, Tatang Bisri, Syafruddin Ilyas, Farhat Farhat, and Adi Muradi Muhar. "TGF-β from mesenchymal stem cell secretome improves sepsis score in murine model." Open Veterinary Journal 16 (2026), 4274-4281. doi:10.5455/OVJ.2026.v16.i7.14


MLA (The Modern Language Association) Style

Sari, Mutiara Indah, Nelva Karmila Jusuf, Delfitri Munir, Agung Putra, Tatang Bisri, Syafruddin Ilyas, Farhat Farhat, and Adi Muradi Muhar. "TGF-β from mesenchymal stem cell secretome improves sepsis score in murine model." Open Veterinary Journal 16.7 (2026), 4274-4281. Print. doi:10.5455/OVJ.2026.v16.i7.14


APA (American Psychological Association) Style

Sari, M. I., Jusuf, . N. K., Munir, . D., Putra, . A., Bisri, . T., Ilyas, . S., Farhat, . F. & Muhar, . A. M. (2026) TGF-β from mesenchymal stem cell secretome improves sepsis score in murine model. Open Veterinary Journal, 16 (7), 4274-4281. doi:10.5455/OVJ.2026.v16.i7.14


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