E-ISSN 2218-6050 | ISSN 2226-4485
 
2024, Vol: 14, Issue: 3
14 / 3Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

OVJ Manuscript Submission Form

Original Article


Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism

Patricia Vidal, Diego Miceli, Elber Soler Arias, Elena D'Anna, Jorge Garcia, Victor Castillo.


Cited By:12

Abstract
Hyperadrenocorticism is a frequent disease in dogs. The excess of circulating cortisol affects different organs and metabolic pathways, producing severe adverse effects that endanger the animal’s life. Among these effects, hypertension and renal damage can be mentioned. A group of 20 dogs with pituitary dependent hyperadrenocorticism (PDH) and 12 control dogs were used to study the following parameters: cortisol and nitric oxide (NO nit/nit) concentrations, diastolic and systolic blood pressure, renal artery resistance index by Doppler ultrasound, the rate of glomerular filtration by radio-renogram excretion and the presence of proteins in urine. Dogs with PDH showed a significantly lower NO nit/nit (P<0.0001) than the controls and this correlated with high values of diastolic and systolic pressure (r= -0.87; P<0.0001 and r= -.081; P<0.0001 respectively). Most dogs (80%) are hypertensive mainly due to an increase in diastolic pressure, which correlated positively with the UPC (r = 0.8; P<0.001) and negatively with the glomerular rate of filtration (r = -0.58; P=0.007). Systolic pressure only increased in 60% of the cases and did not correlate with the mentioned variables. In PDH the decrease of NO affects blood pressure. The diastolic pressure would seem to have the greatest impact on the kidneys, therefore its evaluation and control are important to avoid and/or control renal damage.

Key words: nitric oxide, hyperadrenocorticism pituitary dependent, blood pression, scintigraphy; renal function.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Patricia Vidal
Articles by Diego Miceli
Articles by Elber Soler Arias
Articles by Elena D'Anna
Articles by Jorge Garcia
Articles by Victor Castillo
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Patricia Vidal, Diego Miceli, Elber Soler Arias, Elena DAnna, Jorge Garcia, Victor Castillo. Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism. Open Vet J. 2018; 8(1): 86-95. doi:10.4314/ovj.v8i1.14

Web Style

Patricia Vidal, Diego Miceli, Elber Soler Arias, Elena DAnna, Jorge Garcia, Victor Castillo. Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism. https://www.openveterinaryjournal.com/?mno=283345 [Access: April 10, 2024]. doi:10.4314/ovj.v8i1.14

AMA (American Medical Association) Style

Patricia Vidal, Diego Miceli, Elber Soler Arias, Elena DAnna, Jorge Garcia, Victor Castillo. Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism. Open Vet J. 2018; 8(1): 86-95. doi:10.4314/ovj.v8i1.14


Vancouver/ICMJE Style

Patricia Vidal, Diego Miceli, Elber Soler Arias, Elena DAnna, Jorge Garcia, Victor Castillo. Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism. Open Vet J. (2018), [cited April 10, 2024]; 8(1): 86-95. doi:10.4314/ovj.v8i1.14


Harvard Style

Patricia Vidal, Diego Miceli, Elber Soler Arias, Elena DAnna, Jorge Garcia, Victor Castillo (2018) Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism. Open Vet J, 8 (1), 86-95. doi:10.4314/ovj.v8i1.14


Turabian Style

Patricia Vidal, Diego Miceli, Elber Soler Arias, Elena DAnna, Jorge Garcia, Victor Castillo. 2018. Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism. Open Veterinary Journal, 8 (1), 86-95. doi:10.4314/ovj.v8i1.14


Chicago Style

Patricia Vidal, Diego Miceli, Elber Soler Arias, Elena DAnna, Jorge Garcia, Victor Castillo. "Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism." Open Veterinary Journal 8 (2018), 86-95. doi:10.4314/ovj.v8i1.14


MLA (The Modern Language Association) Style

Patricia Vidal, Diego Miceli, Elber Soler Arias, Elena DAnna, Jorge Garcia, Victor Castillo. "Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism." Open Veterinary Journal 8.1 (2018), 86-95. Print. doi:10.4314/ovj.v8i1.14


APA (American Psychological Association) Style

Patricia Vidal, Diego Miceli, Elber Soler Arias, Elena DAnna, Jorge Garcia, Victor Castillo (2018) Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism. Open Veterinary Journal, 8 (1), 86-95. doi:10.4314/ovj.v8i1.14


Author LoginReviewer LoginAbout PublisherPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyTerms of UseLicense Information

About Open Veterinary Journal

Open Veterinary Journal provides a fast track coupled with high quality peer review process for original research articles, review articles, short communi ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes: Owner, Founder and Editor-in-Chief

Open Veterinary Journal, Faculty of Veterinary Medicine, University of Tripoli

P.O. Box 13662, Tripoli, Libya


Email: ibrahim.eldaghayes@vetmed.edu.ly