E-ISSN 2218-6050 | ISSN 2226-4485
 

Case Report


Indolent, T-cell, Large Granular Lymphocytic Leukaemia (LGLL) in a Dog Presenting with Severe Neutropenia and an Absence of Lymphocytosis

James Elliott, Elizabeth Villiers.


Cited By:3

Abstract
In humans, large granular lymphocytic leukemia (LGLL) is a low-grade, indolent lymphoproliferative disorder of large granular lymphocytes (LGL) associated with autoimmune disorders; including rheumatoid arthritis and single or multiple cytopenias; particularly neutropenia. Therapy largely centres around immunosuppression which aims to resolve the immune-mediated secondary pathology, often without eradicating the neoplastic clone. The most effective agents appear to be cyclophosphamide, cyclosporine and methotrexate. This case report describes the presentation, diagnostics, therapeutic approach and outcome of a 6 year-old Golden Retriever presenting with severe neutropenia. Chlorambucil, prednisolone and cyclosporine failed to improve the neutropenia but subsequent cyclophosphamide resulted in a sustained albeit temporary improvement in neutrophil count and the ability to withdraw prophylactic antibacterials. This case closely mirrors the diagnostics and therapeutic response in human LGLL.

Key words: Granular lymphocyte leukaemia canine T-cell


 
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How to Cite this Article
Pubmed Style

James Elliott, Elizabeth Villiers. Indolent, T-cell, Large Granular Lymphocytic Leukaemia (LGLL) in a Dog Presenting with Severe Neutropenia and an Absence of Lymphocytosis. Open Vet J. 2018; 8(2): 118-124. doi:10.4314/ovj.v8i2.1


Web Style

James Elliott, Elizabeth Villiers. Indolent, T-cell, Large Granular Lymphocytic Leukaemia (LGLL) in a Dog Presenting with Severe Neutropenia and an Absence of Lymphocytosis. https://www.openveterinaryjournal.com/?mno=284049 [Access: February 15, 2024]. doi:10.4314/ovj.v8i2.1


AMA (American Medical Association) Style

James Elliott, Elizabeth Villiers. Indolent, T-cell, Large Granular Lymphocytic Leukaemia (LGLL) in a Dog Presenting with Severe Neutropenia and an Absence of Lymphocytosis. Open Vet J. 2018; 8(2): 118-124. doi:10.4314/ovj.v8i2.1



Vancouver/ICMJE Style

James Elliott, Elizabeth Villiers. Indolent, T-cell, Large Granular Lymphocytic Leukaemia (LGLL) in a Dog Presenting with Severe Neutropenia and an Absence of Lymphocytosis. Open Vet J. (2018), [cited February 15, 2024]; 8(2): 118-124. doi:10.4314/ovj.v8i2.1



Harvard Style

James Elliott, Elizabeth Villiers (2018) Indolent, T-cell, Large Granular Lymphocytic Leukaemia (LGLL) in a Dog Presenting with Severe Neutropenia and an Absence of Lymphocytosis. Open Vet J, 8 (2), 118-124. doi:10.4314/ovj.v8i2.1



Turabian Style

James Elliott, Elizabeth Villiers. 2018. Indolent, T-cell, Large Granular Lymphocytic Leukaemia (LGLL) in a Dog Presenting with Severe Neutropenia and an Absence of Lymphocytosis. Open Veterinary Journal, 8 (2), 118-124. doi:10.4314/ovj.v8i2.1



Chicago Style

James Elliott, Elizabeth Villiers. "Indolent, T-cell, Large Granular Lymphocytic Leukaemia (LGLL) in a Dog Presenting with Severe Neutropenia and an Absence of Lymphocytosis." Open Veterinary Journal 8 (2018), 118-124. doi:10.4314/ovj.v8i2.1



MLA (The Modern Language Association) Style

James Elliott, Elizabeth Villiers. "Indolent, T-cell, Large Granular Lymphocytic Leukaemia (LGLL) in a Dog Presenting with Severe Neutropenia and an Absence of Lymphocytosis." Open Veterinary Journal 8.2 (2018), 118-124. Print. doi:10.4314/ovj.v8i2.1



APA (American Psychological Association) Style

James Elliott, Elizabeth Villiers (2018) Indolent, T-cell, Large Granular Lymphocytic Leukaemia (LGLL) in a Dog Presenting with Severe Neutropenia and an Absence of Lymphocytosis. Open Veterinary Journal, 8 (2), 118-124. doi:10.4314/ovj.v8i2.1