E-ISSN 2218-6050 | ISSN 2226-4485
 

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Expression of Bcl-2 in canine osteosarcoma

F. Piro and L. Leonardi*.


Cited By:14

Abstract
Osteosarcoma (OS) is the most common primary malignancy of bone. It is responsible for 80-85% of the primary bone tumors affecting dogs and it is characterized by aggressive and invasive behavior, with a high metastatic potential. Several studies on cancer and related tumorigenesis, show an involvement of the mechanisms of programmed cell death and cell survival. Many signals seem to be involved in the related mechanism of autophagy and in particular, our interest is focused on the expression of a family of Bcl-2 that seems to be involved either in the control of biomolecular mechanisms like autophagy and apoptosis. In this study we investigated the expression of Bcl-2 in different cases of spontaneous canine osteosarcoma and the related preliminary results are described. We found Bcl-2 activity was increased in OS tissue compared to normal bone tissue. These results suggested that Bcl-2 activity may play an important role in the formation of OS and as a diagnostic for neoplastic activity. However, further research is needed to confirm the role of Bcl-2 activity in OS in canines.

Key words: Autophagy, Bcl-2, Dog, Osteosarcoma.


 
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Pubmed Style

F. Piro and L. Leonardi. Expression of Bcl-2 in canine osteosarcoma. Open Vet J. 2015; 5(1): 27-29. doi:10.5455/OVJ.2015.v5.i1.p27


Web Style

F. Piro and L. Leonardi. Expression of Bcl-2 in canine osteosarcoma. https://www.openveterinaryjournal.com/?mno=302656815 [Access: June 03, 2024]. doi:10.5455/OVJ.2015.v5.i1.p27


AMA (American Medical Association) Style

F. Piro and L. Leonardi. Expression of Bcl-2 in canine osteosarcoma. Open Vet J. 2015; 5(1): 27-29. doi:10.5455/OVJ.2015.v5.i1.p27



Vancouver/ICMJE Style

F. Piro and L. Leonardi. Expression of Bcl-2 in canine osteosarcoma. Open Vet J. (2015), [cited June 03, 2024]; 5(1): 27-29. doi:10.5455/OVJ.2015.v5.i1.p27



Harvard Style

F. Piro and L. Leonardi (2015) Expression of Bcl-2 in canine osteosarcoma. Open Vet J, 5 (1), 27-29. doi:10.5455/OVJ.2015.v5.i1.p27



Turabian Style

F. Piro and L. Leonardi. 2015. Expression of Bcl-2 in canine osteosarcoma. Open Veterinary Journal, 5 (1), 27-29. doi:10.5455/OVJ.2015.v5.i1.p27



Chicago Style

F. Piro and L. Leonardi. "Expression of Bcl-2 in canine osteosarcoma." Open Veterinary Journal 5 (2015), 27-29. doi:10.5455/OVJ.2015.v5.i1.p27



MLA (The Modern Language Association) Style

F. Piro and L. Leonardi. "Expression of Bcl-2 in canine osteosarcoma." Open Veterinary Journal 5.1 (2015), 27-29. Print. doi:10.5455/OVJ.2015.v5.i1.p27



APA (American Psychological Association) Style

F. Piro and L. Leonardi (2015) Expression of Bcl-2 in canine osteosarcoma. Open Veterinary Journal, 5 (1), 27-29. doi:10.5455/OVJ.2015.v5.i1.p27