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Effects of xylazine-ketamine anesthesia on plasma levels of cortisol and vital signs during laparotomy in dogs

H. Naddaf1,*, H. Najafzade Varzi2, S. Sabiza1 and H. Falah3.

Abstract
This study was designed to evaluate effects of xylazine-ketamine anesthesia on plasma levels of cortisol and vital signs during and after laparotomy in dogs. Eight clinically healthy, adult male dogs, weighing 20 kg were used. All dogs were initially sedated by acepromazine. Thirty minutes later, ketamine plus xylazine was used to induce anesthesia. Surgical incision of laparotomy was done. After a 5 min manipulation of the abdominal organs, the incision was sutured. Vital signs including heart rate, respiratory rate and rectal temperature (RT) were recorded at the times of -30: premedication, 0: induction and Surgical incision, 30: End of surgery, 60, 90 and 120 min. Blood was sampled at the above mentioned times and analyzed using a commercial ELISA kit for cortisol. A significant decreasing trend in RT was observed during the studied times. No significant changes were observed in heart rate and respiratory rate (p>0.05), except at the time of 60 respiratory rate significantly decreased when compared to the time of 90 (p=0.026) and 120 (p=0.041). A non-significant but increasing trend in plasma levels of cortisol was observed.

Key words: Anesthesia, Cortisol, Dog, Vital signs, Xylazine-ketamine.


 
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How to Cite this Article
Pubmed Style

H. Naddaf,, H. Najafzade Varzi, S. Sabiza and H. Falah. Effects of xylazine-ketamine anesthesia on plasma levels of cortisol and vital signs during laparotomy in dogs. Open Vet J. 2014; 4(2): 85-89. doi:10.5455/OVJ.2014.v4.i2.p85


Web Style

H. Naddaf,, H. Najafzade Varzi, S. Sabiza and H. Falah. Effects of xylazine-ketamine anesthesia on plasma levels of cortisol and vital signs during laparotomy in dogs. https://www.openveterinaryjournal.com/?mno=302656831 [Access: February 05, 2023]. doi:10.5455/OVJ.2014.v4.i2.p85


AMA (American Medical Association) Style

H. Naddaf,, H. Najafzade Varzi, S. Sabiza and H. Falah. Effects of xylazine-ketamine anesthesia on plasma levels of cortisol and vital signs during laparotomy in dogs. Open Vet J. 2014; 4(2): 85-89. doi:10.5455/OVJ.2014.v4.i2.p85



Vancouver/ICMJE Style

H. Naddaf,, H. Najafzade Varzi, S. Sabiza and H. Falah. Effects of xylazine-ketamine anesthesia on plasma levels of cortisol and vital signs during laparotomy in dogs. Open Vet J. (2014), [cited February 05, 2023]; 4(2): 85-89. doi:10.5455/OVJ.2014.v4.i2.p85



Harvard Style

H. Naddaf,, H. Najafzade Varzi, S. Sabiza and H. Falah (2014) Effects of xylazine-ketamine anesthesia on plasma levels of cortisol and vital signs during laparotomy in dogs. Open Vet J, 4 (2), 85-89. doi:10.5455/OVJ.2014.v4.i2.p85



Turabian Style

H. Naddaf,, H. Najafzade Varzi, S. Sabiza and H. Falah. 2014. Effects of xylazine-ketamine anesthesia on plasma levels of cortisol and vital signs during laparotomy in dogs. Open Veterinary Journal, 4 (2), 85-89. doi:10.5455/OVJ.2014.v4.i2.p85



Chicago Style

H. Naddaf,, H. Najafzade Varzi, S. Sabiza and H. Falah. "Effects of xylazine-ketamine anesthesia on plasma levels of cortisol and vital signs during laparotomy in dogs." Open Veterinary Journal 4 (2014), 85-89. doi:10.5455/OVJ.2014.v4.i2.p85



MLA (The Modern Language Association) Style

H. Naddaf,, H. Najafzade Varzi, S. Sabiza and H. Falah. "Effects of xylazine-ketamine anesthesia on plasma levels of cortisol and vital signs during laparotomy in dogs." Open Veterinary Journal 4.2 (2014), 85-89. Print. doi:10.5455/OVJ.2014.v4.i2.p85



APA (American Psychological Association) Style

H. Naddaf,, H. Najafzade Varzi, S. Sabiza and H. Falah (2014) Effects of xylazine-ketamine anesthesia on plasma levels of cortisol and vital signs during laparotomy in dogs. Open Veterinary Journal, 4 (2), 85-89. doi:10.5455/OVJ.2014.v4.i2.p85