E-ISSN 2218-6050 | ISSN 2226-4485
 
2025, Vol: 15, Issue: 3
15 / 3Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

OVJ Manuscript Submissio Form

Original Article


Iodine-restricted food versus pharmacological therapy in the management of feline hyperthyroidism: A controlled trial in 34 cats

Giorgio Grossi, Andrea Zoia, Paola Palagiano, Nadia Leoni, Federica Bubini Regini, Eleonora Malerba, Angelo Peli, Giacomo Biagi, Federico Fracassi.


Cited By:15

Abstract
Hyperthyroidism is a common endocrinopathy of middle-aged and elderly cats. A dietary treatment has been proposed as alternative to traditional therapies. The aim of this prospective study was to compare the efficacy of an iodine-restricted food versus pharmacological therapy with methimazole in client-owned cats with hyperthyroidism. Indoor cats with newly diagnosed hyperthyroidism (consistent clinical signs and serum total thyroxine concentration greater than 50 nmol/L) were assigned to one of three groups: (A) received an iodine-restricted food as a single therapy; (B) received transdermal methimazole in pluronic lecithin organogel; (C) received oral methimazole. In all groups clinical parameters, biochemistry and serum total thyroxine were evaluated at baseline and 10, 30, 60, and 90 days after treatment began. Thirty-four cats were enrolled in the study (group A: n=14; group B: n=11; group C: n=9). No significant differences were found between groups at diagnosis for signalment, clinical and laboratory findings, including serum total thyroxine concentrations. In all groups, serum total thyroxine concentration decreased significantly following the baseline measurement. After 90 days treatment, serum creatinine increased significantly only in the methimazole-treated groups. Liver enzyme activities decreased significantly only in group B, while no significant decreases were detected in groups A and C at any time. These results suggest that iodine-restricted food is effective at reducing the total thyroxine concentration in the serum of hyperthyroid cats. Moreover, the iodine-restricted food did not cause any increase of serum creatinine concentrations and failed to improve liver enzymes abnormalities. These findings could indicate a persistent hyperthyroid state in cats treated with iodine-restricted food despite normalization of serum total thyroxine concentrations.

Key words: methimazole, pluronic lecithin organogel, liver enzymes, iodine-restricted food, thyroxine


 
ARTICLE TOOLS
Abstract
PDF Fulltext
HTML Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Giorgio Grossi
Articles by Andrea Zoia
Articles by Paola Palagiano
Articles by Nadia Leoni
Articles by Federica Bubini Regini
Articles by Eleonora Malerba
Articles by Angelo Peli
Articles by Giacomo Biagi
Articles by Federico Fracassi
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Grossi G, Zoia A, Palagiano P, Leoni N, Regini FB, Malerba E, Peli A, Biagi G, Fracassi F. Iodine-restricted food versus pharmacological therapy in the management of feline hyperthyroidism: A controlled trial in 34 cats. Open Vet J. 2019; 9(3): 196-204. doi:10.4314/ovj.v9i3.3

Web Style

Grossi G, Zoia A, Palagiano P, Leoni N, Regini FB, Malerba E, Peli A, Biagi G, Fracassi F. Iodine-restricted food versus pharmacological therapy in the management of feline hyperthyroidism: A controlled trial in 34 cats. https://www.openveterinaryjournal.com/?mno=31082 [Access: April 28, 2025]. doi:10.4314/ovj.v9i3.3

AMA (American Medical Association) Style

Grossi G, Zoia A, Palagiano P, Leoni N, Regini FB, Malerba E, Peli A, Biagi G, Fracassi F. Iodine-restricted food versus pharmacological therapy in the management of feline hyperthyroidism: A controlled trial in 34 cats. Open Vet J. 2019; 9(3): 196-204. doi:10.4314/ovj.v9i3.3


Vancouver/ICMJE Style

Grossi G, Zoia A, Palagiano P, Leoni N, Regini FB, Malerba E, Peli A, Biagi G, Fracassi F. Iodine-restricted food versus pharmacological therapy in the management of feline hyperthyroidism: A controlled trial in 34 cats. Open Vet J. (2019), [cited April 28, 2025]; 9(3): 196-204. doi:10.4314/ovj.v9i3.3


Harvard Style

Grossi, G., Zoia, . A., Palagiano, . P., Leoni, . N., Regini, . F. B., Malerba, . E., Peli, . A., Biagi, . G. & Fracassi, . F. (2019) Iodine-restricted food versus pharmacological therapy in the management of feline hyperthyroidism: A controlled trial in 34 cats. Open Vet J, 9 (3), 196-204. doi:10.4314/ovj.v9i3.3


Turabian Style

Grossi, Giorgio, Andrea Zoia, Paola Palagiano, Nadia Leoni, Federica Bubini Regini, Eleonora Malerba, Angelo Peli, Giacomo Biagi, and Federico Fracassi. 2019. Iodine-restricted food versus pharmacological therapy in the management of feline hyperthyroidism: A controlled trial in 34 cats. Open Veterinary Journal, 9 (3), 196-204. doi:10.4314/ovj.v9i3.3


Chicago Style

Grossi, Giorgio, Andrea Zoia, Paola Palagiano, Nadia Leoni, Federica Bubini Regini, Eleonora Malerba, Angelo Peli, Giacomo Biagi, and Federico Fracassi. "Iodine-restricted food versus pharmacological therapy in the management of feline hyperthyroidism: A controlled trial in 34 cats." Open Veterinary Journal 9 (2019), 196-204. doi:10.4314/ovj.v9i3.3


MLA (The Modern Language Association) Style

Grossi, Giorgio, Andrea Zoia, Paola Palagiano, Nadia Leoni, Federica Bubini Regini, Eleonora Malerba, Angelo Peli, Giacomo Biagi, and Federico Fracassi. "Iodine-restricted food versus pharmacological therapy in the management of feline hyperthyroidism: A controlled trial in 34 cats." Open Veterinary Journal 9.3 (2019), 196-204. Print. doi:10.4314/ovj.v9i3.3


APA (American Psychological Association) Style

Grossi, G., Zoia, . A., Palagiano, . P., Leoni, . N., Regini, . F. B., Malerba, . E., Peli, . A., Biagi, . G. & Fracassi, . F. (2019) Iodine-restricted food versus pharmacological therapy in the management of feline hyperthyroidism: A controlled trial in 34 cats. Open Veterinary Journal, 9 (3), 196-204. doi:10.4314/ovj.v9i3.3


Author LoginReviewer LoginAbout PublisherPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyTerms of UseLicense InformationCopyright Information

About Open Veterinary Journal

Open Veterinary Journal provides a fast track coupled with high quality peer review process for original research articles, review articles, short communi ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes: Owner, Founder and Editor-in-Chief

Open Veterinary Journal


Faculty of Veterinary Medicine, University of Tripoli

P.O. Box 13662, Tripoli, Libya

and


Eldaghayes Publisher

www.eldaghayes.com 

Email: ibrahim.eldaghayes@vetmed.edu.ly