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Effects of timolol maleate eye drops on experimentally dilated cardiomyopathy and healthy rabbits

Mitsuhiro Isaka, Reimi Hayashida, Yuumi Tamashima, Ryuji Araki.

Abstract
Background: Dilated cardiomyopathy (DCM) is the most frequently diagnosed cardiomyopathy in rabbits. Timolol maleate (nonselective beta-blockers), which reduces the heart rate (HR) and blood pressure, has been used for glaucoma. However, this effect has not been assessed in a rabbit DCM model.
Aim: This study aimed to evaluate the circulatory effects of 0.5% timolol maleate eye drops in rabbit DCM models.
Methods: Rabbits were randomly divided into healthy (n = 8) and DCM rabbits (n = 8). Rabbit DCM models were established through intravenous administration of daunorubicin (4 mg/kg/week), which is an anthracycline anticancer drug, for 6 weeks. We measured the HR, mean arterial pressure (MAP), and echocardiography before (pre) as well as at 10, 30, 60, and 120 minutes after timolol maleate administration.
Results: 0.5% timolol maleate eye drops significantly reduced the HR at 10, 30, and 60 minutes in DCM models and 10 minutes in healthy rabbits; however, there were no alterations in MAP. There was a significant fraction shortening elevation at 10 and 120 minutes in DCM models; moreover, there were marked ejection fraction elevations at all measurement points in only DCM models.
Conclusion: Timolol maleate eye drops exert several effects on the circulatory system in rabbit DCM models and healthy rabbits.

Key words: dilated cardiomyopathy, eye drop, rabbit, timolol


 
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How to Cite this Article
Pubmed Style

Isaka M, Hayashida R, Tamashima Y, Araki R, . Effects of timolol maleate eye drops on experimentally dilated cardiomyopathy and healthy rabbits. Open Vet J. 2021; 11(3): 390-393. doi:10.5455/OVJ.2021.v11.i3.9


Web Style

Isaka M, Hayashida R, Tamashima Y, Araki R, . Effects of timolol maleate eye drops on experimentally dilated cardiomyopathy and healthy rabbits. https://www.openveterinaryjournal.com/?mno=70417 [Access: February 06, 2023]. doi:10.5455/OVJ.2021.v11.i3.9


AMA (American Medical Association) Style

Isaka M, Hayashida R, Tamashima Y, Araki R, . Effects of timolol maleate eye drops on experimentally dilated cardiomyopathy and healthy rabbits. Open Vet J. 2021; 11(3): 390-393. doi:10.5455/OVJ.2021.v11.i3.9



Vancouver/ICMJE Style

Isaka M, Hayashida R, Tamashima Y, Araki R, . Effects of timolol maleate eye drops on experimentally dilated cardiomyopathy and healthy rabbits. Open Vet J. (2021), [cited February 06, 2023]; 11(3): 390-393. doi:10.5455/OVJ.2021.v11.i3.9



Harvard Style

Isaka, M., Hayashida, R., Tamashima, Y., Araki, R. & (2021) Effects of timolol maleate eye drops on experimentally dilated cardiomyopathy and healthy rabbits. Open Vet J, 11 (3), 390-393. doi:10.5455/OVJ.2021.v11.i3.9



Turabian Style

Isaka, Mitsuhiro, Reimi Hayashida, Yuumi Tamashima, Ryuji Araki, and . 2021. Effects of timolol maleate eye drops on experimentally dilated cardiomyopathy and healthy rabbits. Open Veterinary Journal, 11 (3), 390-393. doi:10.5455/OVJ.2021.v11.i3.9



Chicago Style

Isaka, Mitsuhiro, Reimi Hayashida, Yuumi Tamashima, Ryuji Araki, and . "Effects of timolol maleate eye drops on experimentally dilated cardiomyopathy and healthy rabbits." Open Veterinary Journal 11 (2021), 390-393. doi:10.5455/OVJ.2021.v11.i3.9



MLA (The Modern Language Association) Style

Isaka, Mitsuhiro, Reimi Hayashida, Yuumi Tamashima, Ryuji Araki, and . "Effects of timolol maleate eye drops on experimentally dilated cardiomyopathy and healthy rabbits." Open Veterinary Journal 11.3 (2021), 390-393. Print. doi:10.5455/OVJ.2021.v11.i3.9



APA (American Psychological Association) Style

Isaka, M., Hayashida, R., Tamashima, Y., Araki, R. & (2021) Effects of timolol maleate eye drops on experimentally dilated cardiomyopathy and healthy rabbits. Open Veterinary Journal, 11 (3), 390-393. doi:10.5455/OVJ.2021.v11.i3.9