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Original Article


Protective role of cod liver oil on hippocampal oxidative damage and neuronal count in Wistar rat model of comorbid depression

Dimple Shet, Nayanatara Arun Kumar, Megha Gokul, Rekha Durgadas Kini, Aradhana Marathe, Sowndarya Kollampare, Vandana Blossom.


Abstract
Background:
Proper nutrition and balanced diet have profound influence on mental wellbeing. Nutritional psychiatry plays an important role in influencing healthy mind and body. The animal model of chronic unpredictable stress has been considered as the effective model to explore research on anxiety and depression.
Aim:
The present study was aimed to explore the protective role of cod liver oil on various biochemical and neuronal analysis in the hippocampus tissue of Wistar rat model of comorbid depression.
Methods:
Healthy adult albino rats of Wistar strain weighing (120-160 grams) were divided into control group and experimental groups. These groups were further categorized into various subgroups based on the stress exposure, cod liver oil and antidepressant treatment. Six animals were taken in each group. The duration of stress exposure was for 15 days. After the experimentation procedure, the animals were anaesthetized, and hippocampus was dissected for the estimations of various biochemical and neurological parameters.
Results:
The combination of cod liver oil with the antidepressant significantly (P<0.001) decreased the lipid peroxidation level. Total antioxidant and SOD level significantly increased (P<0.001) in the hippocampus. Treatment of cod liver oil during the stress exposure increased (P<0.001) the neuronal count.
Conclusion:
Cod liver oil proved to be the effective antidepressant agent by increasing the antioxidants and promoting neurogenesis in the hippocampus.

Key words: Depression, Cod liver oil, Antidepressant, Hippocampus, Antioxidants


 
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How to Cite this Article
Pubmed Style

Shet D, Kumar NA, Gokul M, Kini RD, Marathe A, Kollampare S, Blossom V. Protective role of cod liver oil on hippocampal oxidative damage and neuronal count in Wistar rat model of comorbid depression. Open Vet J. 2023; 13(4): 473-480. doi:10.5455/OVJ.2023.v13.i4.9

Web Style

Shet D, Kumar NA, Gokul M, Kini RD, Marathe A, Kollampare S, Blossom V. Protective role of cod liver oil on hippocampal oxidative damage and neuronal count in Wistar rat model of comorbid depression. https://www.openveterinaryjournal.com/?mno=70724 [Access: April 21, 2024]. doi:10.5455/OVJ.2023.v13.i4.9

AMA (American Medical Association) Style

Shet D, Kumar NA, Gokul M, Kini RD, Marathe A, Kollampare S, Blossom V. Protective role of cod liver oil on hippocampal oxidative damage and neuronal count in Wistar rat model of comorbid depression. Open Vet J. 2023; 13(4): 473-480. doi:10.5455/OVJ.2023.v13.i4.9


Vancouver/ICMJE Style

Shet D, Kumar NA, Gokul M, Kini RD, Marathe A, Kollampare S, Blossom V. Protective role of cod liver oil on hippocampal oxidative damage and neuronal count in Wistar rat model of comorbid depression. Open Vet J. (2023), [cited April 21, 2024]; 13(4): 473-480. doi:10.5455/OVJ.2023.v13.i4.9


Harvard Style

Shet, D., Kumar, . N. A., Gokul, . M., Kini, . R. D., Marathe, . A., Kollampare, . S. & Blossom, . V. (2023) Protective role of cod liver oil on hippocampal oxidative damage and neuronal count in Wistar rat model of comorbid depression. Open Vet J, 13 (4), 473-480. doi:10.5455/OVJ.2023.v13.i4.9


Turabian Style

Shet, Dimple, Nayanatara Arun Kumar, Megha Gokul, Rekha Durgadas Kini, Aradhana Marathe, Sowndarya Kollampare, and Vandana Blossom. 2023. Protective role of cod liver oil on hippocampal oxidative damage and neuronal count in Wistar rat model of comorbid depression. Open Veterinary Journal, 13 (4), 473-480. doi:10.5455/OVJ.2023.v13.i4.9


Chicago Style

Shet, Dimple, Nayanatara Arun Kumar, Megha Gokul, Rekha Durgadas Kini, Aradhana Marathe, Sowndarya Kollampare, and Vandana Blossom. "Protective role of cod liver oil on hippocampal oxidative damage and neuronal count in Wistar rat model of comorbid depression." Open Veterinary Journal 13 (2023), 473-480. doi:10.5455/OVJ.2023.v13.i4.9


MLA (The Modern Language Association) Style

Shet, Dimple, Nayanatara Arun Kumar, Megha Gokul, Rekha Durgadas Kini, Aradhana Marathe, Sowndarya Kollampare, and Vandana Blossom. "Protective role of cod liver oil on hippocampal oxidative damage and neuronal count in Wistar rat model of comorbid depression." Open Veterinary Journal 13.4 (2023), 473-480. Print. doi:10.5455/OVJ.2023.v13.i4.9


APA (American Psychological Association) Style

Shet, D., Kumar, . N. A., Gokul, . M., Kini, . R. D., Marathe, . A., Kollampare, . S. & Blossom, . V. (2023) Protective role of cod liver oil on hippocampal oxidative damage and neuronal count in Wistar rat model of comorbid depression. Open Veterinary Journal, 13 (4), 473-480. doi:10.5455/OVJ.2023.v13.i4.9


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