E-ISSN 2218-6050 | ISSN 2226-4485
 

Original Article


Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma

Veronica Mollica Govoni, Claudio Pigoli, Felipe Augusto Ruiz Sueiro, Fernanda Zuliani, Thayna Oliveira da Silva, Juliany Gomes Quitzan, Renee Laufer-Amorim, Valeria Grieco, Carlos Eduardo Fonseca-Alves.


Cited By:3

Abstract
Urothelial carcinoma (UC), also known as transitional cell carcinoma, is the most common malignant tumor of the canine urinary bladder and represents a model for studying human bladder cancer. However, the existing literature has limited data on the clinicopathological characteristics of these tumors and their prognostic value. The aim of this study was to evaluate such factors, correlating them with follow-up, in a group of 32 dogs with bladder UC. Clinical data of these cases, submitted to São Paulo State University (UNESP) and VetPat Private Laboratory (São Paulo/Brazil), were recorded between January 2000 and November 2019. For each case, formalin-fixed and paraffin-embedded sections were stained with hematoxylin-eosin and histologically evaluated. Survival analysis was performed, and prognostic value of the presence of lymphatic invasion and the treatment used was determined. Dogs with neoplastic lymphatic vessel invasion had lower overall survival compared with those without lymphatic invasion, and dogs that received vinblastine in addition to surgery had higher global survival when compared with animals that received carboplatin in addition to surgery. The results obtained show the importance of further studies regarding the prognostic value of the two factors demonstrated as potential survival predictors, especially the lymphatic vessel invasion.

Key words: Dog; transitional cell carcinoma; prognosis; bladder cancer


 
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How to Cite this Article
Pubmed Style

VMG, Pigoli C, Sueiro FAR, Zuliani F, Silva TOd, Quitzan JG, Laufer-Amorim R, Grieco V, Fonseca-Alves CE. Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma. Open Vet J. 2021; 11(4): 535-543. doi:10.5455/OVJ.2021.v11.i4.3


Web Style

VMG, Pigoli C, Sueiro FAR, Zuliani F, Silva TOd, Quitzan JG, Laufer-Amorim R, Grieco V, Fonseca-Alves CE. Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma. https://www.openveterinaryjournal.com/?mno=71029 [Access: February 13, 2024]. doi:10.5455/OVJ.2021.v11.i4.3


AMA (American Medical Association) Style

VMG, Pigoli C, Sueiro FAR, Zuliani F, Silva TOd, Quitzan JG, Laufer-Amorim R, Grieco V, Fonseca-Alves CE. Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma. Open Vet J. 2021; 11(4): 535-543. doi:10.5455/OVJ.2021.v11.i4.3



Vancouver/ICMJE Style

VMG, Pigoli C, Sueiro FAR, Zuliani F, Silva TOd, Quitzan JG, Laufer-Amorim R, Grieco V, Fonseca-Alves CE. Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma. Open Vet J. (2021), [cited February 13, 2024]; 11(4): 535-543. doi:10.5455/OVJ.2021.v11.i4.3



Harvard Style

, V. M. G., Pigoli, . C., Sueiro, . F. A. R., Zuliani, . F., Silva, . T. O. d., Quitzan, . J. G., Laufer-Amorim, . R., Grieco, . V. & Fonseca-Alves, . C. E. (2021) Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma. Open Vet J, 11 (4), 535-543. doi:10.5455/OVJ.2021.v11.i4.3



Turabian Style

, Veronica Mollica Govoni, Claudio Pigoli, Felipe Augusto Ruiz Sueiro, Fernanda Zuliani, Thayna Oliveira da Silva, Juliany Gomes Quitzan, Renee Laufer-Amorim, Valeria Grieco, and Carlos Eduardo Fonseca-Alves. 2021. Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma. Open Veterinary Journal, 11 (4), 535-543. doi:10.5455/OVJ.2021.v11.i4.3



Chicago Style

, Veronica Mollica Govoni, Claudio Pigoli, Felipe Augusto Ruiz Sueiro, Fernanda Zuliani, Thayna Oliveira da Silva, Juliany Gomes Quitzan, Renee Laufer-Amorim, Valeria Grieco, and Carlos Eduardo Fonseca-Alves. "Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma." Open Veterinary Journal 11 (2021), 535-543. doi:10.5455/OVJ.2021.v11.i4.3



MLA (The Modern Language Association) Style

, Veronica Mollica Govoni, Claudio Pigoli, Felipe Augusto Ruiz Sueiro, Fernanda Zuliani, Thayna Oliveira da Silva, Juliany Gomes Quitzan, Renee Laufer-Amorim, Valeria Grieco, and Carlos Eduardo Fonseca-Alves. "Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma." Open Veterinary Journal 11.4 (2021), 535-543. Print. doi:10.5455/OVJ.2021.v11.i4.3



APA (American Psychological Association) Style

, V. M. G., Pigoli, . C., Sueiro, . F. A. R., Zuliani, . F., Silva, . T. O. d., Quitzan, . J. G., Laufer-Amorim, . R., Grieco, . V. & Fonseca-Alves, . C. E. (2021) Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma. Open Veterinary Journal, 11 (4), 535-543. doi:10.5455/OVJ.2021.v11.i4.3