E-ISSN 2218-6050 | ISSN 2226-4485
 

Original Article


Vitamin D mitigates adult onset diseases in male and female mice induced by early-life exposure to endocrine disruptor BPA

Mohamed A Al-Griw , Zohour M Marwan, Ismail M Hdud, Taher Shaibi .

Abstract
Background: During early development, environmental compounds can induce adult-onset diseases, and disrupts the circulating vitamin D (VitD) levels.
Aim: The aim of this study was to examine the protective role of VitD against the adverse effects of BPA on male and female mice.
Methods: A total of 60 male and female Swiss albino mice (3 weeks old) were randomly divided into 5 groups; each consists of 12 mice (6 males and 6 females) and treated as follows: Group I, received no treatment (sham control); Group II, sterile corn oil only (vehicle control); Group III, BPA (400 μg/kg); Group IV, VitD (2195 IU/kg) and Group V, BPA+VitD. At 10.5 weeks old, the animals were sacrificed in order to conduct histological examinations.
Results: BPA-exposed mice were found to have neurobehavioral abnormalities, heart, kidney, and lung diseases with increased apoptotic indices in both sexes. On the other hand, treatment of BPA mice with VitD altered this scenario into modulated the motor activity, enhanced the body and organ weights, and preserved the heart, kidney, and lung architecture alongside with decreased percent apoptotic index.
Conclusions: Our findings illustrate that VitD protects mice against BPA-induced heart, kidney, and lung abnormalities.

Key words: Bisphenol A; Heart; Lung; Kidney; Vitamin D


 
ARTICLE TOOLS
Abstract
PDF Fulltext
HTML Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Mohamed A Al-Griw
Articles by Zohour M Marwan
Articles by Ismail M Hdud
Articles by Taher Shaibi
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

MAA, Marwan ZM, Hdud IM, TS, . Vitamin D mitigates adult onset diseases in male and female mice induced by early-life exposure to endocrine disruptor BPA. Open Vet J. 2021; 11(3): 407-417. doi:10.5455/OVJ.2021.v11.i3.12


Web Style

MAA, Marwan ZM, Hdud IM, TS, . Vitamin D mitigates adult onset diseases in male and female mice induced by early-life exposure to endocrine disruptor BPA. https://www.openveterinaryjournal.com/?mno=73996 [Access: February 06, 2023]. doi:10.5455/OVJ.2021.v11.i3.12


AMA (American Medical Association) Style

MAA, Marwan ZM, Hdud IM, TS, . Vitamin D mitigates adult onset diseases in male and female mice induced by early-life exposure to endocrine disruptor BPA. Open Vet J. 2021; 11(3): 407-417. doi:10.5455/OVJ.2021.v11.i3.12



Vancouver/ICMJE Style

MAA, Marwan ZM, Hdud IM, TS, . Vitamin D mitigates adult onset diseases in male and female mice induced by early-life exposure to endocrine disruptor BPA. Open Vet J. (2021), [cited February 06, 2023]; 11(3): 407-417. doi:10.5455/OVJ.2021.v11.i3.12



Harvard Style

, M. A. A., Marwan, Z. M., Hdud, I. M., , T. S. & (2021) Vitamin D mitigates adult onset diseases in male and female mice induced by early-life exposure to endocrine disruptor BPA. Open Vet J, 11 (3), 407-417. doi:10.5455/OVJ.2021.v11.i3.12



Turabian Style

, Mohamed A Al-Griw, Zohour M Marwan, Ismail M Hdud, Taher Shaibi, and . 2021. Vitamin D mitigates adult onset diseases in male and female mice induced by early-life exposure to endocrine disruptor BPA. Open Veterinary Journal, 11 (3), 407-417. doi:10.5455/OVJ.2021.v11.i3.12



Chicago Style

, Mohamed A Al-Griw, Zohour M Marwan, Ismail M Hdud, Taher Shaibi, and . "Vitamin D mitigates adult onset diseases in male and female mice induced by early-life exposure to endocrine disruptor BPA." Open Veterinary Journal 11 (2021), 407-417. doi:10.5455/OVJ.2021.v11.i3.12



MLA (The Modern Language Association) Style

, Mohamed A Al-Griw, Zohour M Marwan, Ismail M Hdud, Taher Shaibi, and . "Vitamin D mitigates adult onset diseases in male and female mice induced by early-life exposure to endocrine disruptor BPA." Open Veterinary Journal 11.3 (2021), 407-417. Print. doi:10.5455/OVJ.2021.v11.i3.12



APA (American Psychological Association) Style

, M. A. A., Marwan, Z. M., Hdud, I. M., , T. S. & (2021) Vitamin D mitigates adult onset diseases in male and female mice induced by early-life exposure to endocrine disruptor BPA. Open Veterinary Journal, 11 (3), 407-417. doi:10.5455/OVJ.2021.v11.i3.12