E-ISSN 2218-6050 | ISSN 2226-4485
 
2025, Vol: 15, Issue: 2
15 / 2Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles

Review Article


Transcranial photobiomodulation (laser) therapy for cognitive impairment: a review of molecular mechanisms and potential application to canine cognitive dysfunction (CCD)

Curtis Wells Dewey, Matthew Warren Brunke, Kasie Sakovitch.


Cited By:15

Abstract
Alzheimer’s disease (AD) is a common degenerative brain disorder of aging people which shares many clinical and pathological features with canine cognitive dysfunction (CCD). CCD is considered a naturally occurring model of human AD. Transcranial photobiomodulation (tPBMT) therapy, also known as transcranial laser therapy, entails delivering photons of near infrared to infrared light from the skin surface of the scalp to the underlying brain. Specific molecular cellular receptors, called chromophores, absorb this energy, and use it to initiate biological reactions with potential therapeutic benefit. Improvement in cognitive ability using tPBMT has been documented in rodent AD models and human clinical trials. The purposes of this review are to provide an overview of the suspected molecular mechanisms of action of tPBMT for treatment of cognitive decline and to propose potential application of this treatment modality for dogs affected by CCD.

Key words: Canine, cognitive, dysfunction, Alzheimer’s, photobiomodulation, laser, transcranial, mitochondria, cytochrome c oxidase, amyloid


 
ARTICLE TOOLS
Abstract
PDF Fulltext
HTML Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Curtis Wells Dewey
Articles by Matthew Warren Brunke
Articles by Kasie Sakovitch
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Dewey CW, Brunke MW, Sakovitch K. Transcranial photobiomodulation (laser) therapy for cognitive impairment: a review of molecular mechanisms and potential application to canine cognitive dysfunction (CCD). Open Vet J. 2022; 12(2): 256-263. doi:10.5455/OVJ.2022.v12.i2.14

Web Style

Dewey CW, Brunke MW, Sakovitch K. Transcranial photobiomodulation (laser) therapy for cognitive impairment: a review of molecular mechanisms and potential application to canine cognitive dysfunction (CCD). https://www.openveterinaryjournal.com/?mno=93802 [Access: March 13, 2025]. doi:10.5455/OVJ.2022.v12.i2.14

AMA (American Medical Association) Style

Dewey CW, Brunke MW, Sakovitch K. Transcranial photobiomodulation (laser) therapy for cognitive impairment: a review of molecular mechanisms and potential application to canine cognitive dysfunction (CCD). Open Vet J. 2022; 12(2): 256-263. doi:10.5455/OVJ.2022.v12.i2.14


Vancouver/ICMJE Style

Dewey CW, Brunke MW, Sakovitch K. Transcranial photobiomodulation (laser) therapy for cognitive impairment: a review of molecular mechanisms and potential application to canine cognitive dysfunction (CCD). Open Vet J. (2022), [cited March 13, 2025]; 12(2): 256-263. doi:10.5455/OVJ.2022.v12.i2.14


Harvard Style

Dewey, C. W., Brunke, . M. W. & Sakovitch, . K. (2022) Transcranial photobiomodulation (laser) therapy for cognitive impairment: a review of molecular mechanisms and potential application to canine cognitive dysfunction (CCD). Open Vet J, 12 (2), 256-263. doi:10.5455/OVJ.2022.v12.i2.14


Turabian Style

Dewey, Curtis Wells, Matthew Warren Brunke, and Kasie Sakovitch. 2022. Transcranial photobiomodulation (laser) therapy for cognitive impairment: a review of molecular mechanisms and potential application to canine cognitive dysfunction (CCD). Open Veterinary Journal, 12 (2), 256-263. doi:10.5455/OVJ.2022.v12.i2.14


Chicago Style

Dewey, Curtis Wells, Matthew Warren Brunke, and Kasie Sakovitch. "Transcranial photobiomodulation (laser) therapy for cognitive impairment: a review of molecular mechanisms and potential application to canine cognitive dysfunction (CCD)." Open Veterinary Journal 12 (2022), 256-263. doi:10.5455/OVJ.2022.v12.i2.14


MLA (The Modern Language Association) Style

Dewey, Curtis Wells, Matthew Warren Brunke, and Kasie Sakovitch. "Transcranial photobiomodulation (laser) therapy for cognitive impairment: a review of molecular mechanisms and potential application to canine cognitive dysfunction (CCD)." Open Veterinary Journal 12.2 (2022), 256-263. Print. doi:10.5455/OVJ.2022.v12.i2.14


APA (American Psychological Association) Style

Dewey, C. W., Brunke, . M. W. & Sakovitch, . K. (2022) Transcranial photobiomodulation (laser) therapy for cognitive impairment: a review of molecular mechanisms and potential application to canine cognitive dysfunction (CCD). Open Veterinary Journal, 12 (2), 256-263. doi:10.5455/OVJ.2022.v12.i2.14


Author LoginReviewer LoginAbout PublisherPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyTerms of UseLicense InformationCopyright Information

About Open Veterinary Journal

Open Veterinary Journal provides a fast track coupled with high quality peer review process for original research articles, review articles, short communi ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes: Owner, Founder and Editor-in-Chief

Open Veterinary Journal


Faculty of Veterinary Medicine, University of Tripoli

P.O. Box 13662, Tripoli, Libya

and


Eldaghayes Publisher

www.eldagpublisher.com 

Email: ibrahim.eldaghayes@vetmed.edu.ly