E-ISSN 2218-6050 | ISSN 2226-4485
 

Original Article


Vitamin D inhibited endometriosis development in mice model through interleukin 17 modulation

Alfi Ruham Burjiah, Ashon Sa’adi, Widjiati Widjiati.


Cited By:8

Abstract
Background: Endometriosis is a common benign, estrogen-dependent, and chronic gynecological disease. Immune system disturbances and inflammatory abnormalities were involved in the pathogenesis of endometriosis. , Therefore, it is logical to use vitamin D, which has an immunomodulatory capacity, as supportive therapy for endometriosis.
Aims: This research time to study the effect of different doses of vitamin D on IL-17 expression in endometriosis mice models.
Methods: Endometriosis was induced in twenty-four mice divided into four groups of six. Group C received no treatment, while groups T1, T2, and T3 received graded doses of vitamin D to the stomach, sequentially 8 IU, 16 IU, and 24 IU for three weeks. Interleukin-17 expression and the extent of endometriotic peritoneal lesions were also measured and analyzed. Statistical tests were performed to see the difference in the mean area of endometriosis lesions and IL-17 expression between the control and treatment groups, as well as the correlation between the extent of endometriosis lesions and IL-17. We performed a statistical test to determine whether stratified doses have different IL-17 and endometriosis area outcomes.
Results: The area of endometriosis lesions was decreased after 16 IU and 24 IU of vitamin D administration (p 0.023 and 0.009). Endometriosis lesions also tended to be smaller after 8 IU of vitamin D supplementation, although insignificant (p > 0.05). Interleukin-17 expression was significantly lower after 24 IU vitamin D administration (p = 0.004). Vitamin D doses of 8 IU and 16 IU caused lower IL-17 expression, although not significant (p = 0.452 and p = 0.645). The regulation of IL-17 expression was significantly dependent on the dose level of vitamin D with an optimal dose of 24 IU (p = 0.004). This dose also caused the smallest endometriosis lesion, although not optimal (p > 0.05). IL-17 expression was moderately and positively correlated with the extent of endometriosis lesions (p = 0.012, rho = 0.505).
Conclusion: By modulating the expression of interleukin-17 in endometriotic lesions, vitamin D inhibits the development of endometriotic lesions in the endometriosis mice model. The optimal vitamin D dose in this study was 24 IU.

Key words: Endometriosis lesion size, Interleukin 17, Reproductive Health, Vitamin D


 
ARTICLE TOOLS
Abstract
PDF Fulltext
HTML Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Alfi Ruham Burjiah
Articles by Ashon Sa’adi
Articles by Widjiati Widjiati
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Burjiah AR, Sa'adi A, Widjiati W, . Vitamin D inhibited endometriosis development in mice model through interleukin 17 modulation. Open Vet J. 2022; 12(6): 956-964. doi:10.5455/OVJ.2022.v12.i6.23


Web Style

Burjiah AR, Sa'adi A, Widjiati W, . Vitamin D inhibited endometriosis development in mice model through interleukin 17 modulation. https://www.openveterinaryjournal.com/?mno=115890 [Access: November 07, 2024]. doi:10.5455/OVJ.2022.v12.i6.23


AMA (American Medical Association) Style

Burjiah AR, Sa'adi A, Widjiati W, . Vitamin D inhibited endometriosis development in mice model through interleukin 17 modulation. Open Vet J. 2022; 12(6): 956-964. doi:10.5455/OVJ.2022.v12.i6.23



Vancouver/ICMJE Style

Burjiah AR, Sa'adi A, Widjiati W, . Vitamin D inhibited endometriosis development in mice model through interleukin 17 modulation. Open Vet J. (2022), [cited November 07, 2024]; 12(6): 956-964. doi:10.5455/OVJ.2022.v12.i6.23



Harvard Style

Burjiah, A. R., Sa'adi, A., Widjiati, W. & (2022) Vitamin D inhibited endometriosis development in mice model through interleukin 17 modulation. Open Vet J, 12 (6), 956-964. doi:10.5455/OVJ.2022.v12.i6.23



Turabian Style

Burjiah, Alfi Ruham, Ashon Sa'adi, Widjiati Widjiati, and . 2022. Vitamin D inhibited endometriosis development in mice model through interleukin 17 modulation. Open Veterinary Journal, 12 (6), 956-964. doi:10.5455/OVJ.2022.v12.i6.23



Chicago Style

Burjiah, Alfi Ruham, Ashon Sa'adi, Widjiati Widjiati, and . "Vitamin D inhibited endometriosis development in mice model through interleukin 17 modulation." Open Veterinary Journal 12 (2022), 956-964. doi:10.5455/OVJ.2022.v12.i6.23



MLA (The Modern Language Association) Style

Burjiah, Alfi Ruham, Ashon Sa'adi, Widjiati Widjiati, and . "Vitamin D inhibited endometriosis development in mice model through interleukin 17 modulation." Open Veterinary Journal 12.6 (2022), 956-964. Print. doi:10.5455/OVJ.2022.v12.i6.23



APA (American Psychological Association) Style

Burjiah, A. R., Sa'adi, A., Widjiati, W. & (2022) Vitamin D inhibited endometriosis development in mice model through interleukin 17 modulation. Open Veterinary Journal, 12 (6), 956-964. doi:10.5455/OVJ.2022.v12.i6.23