E-ISSN 2218-6050 | ISSN 2226-4485
 

Original Article


Potential role of Cytotoxic T-Lymphocyte Antigen 2 alpha in secretory activity of endocrine cells in mouse adenohyphphysis

Claudius Luziga.


Abstract
The peptide hormones of the adenohypophysis are produced by proteolytic processing of their prohormone precursors. Cathepsin L is known to function as a major proteolytic enzyme involved in the production of the peptide hormones. The structure of the propeptide region of cathepsin L is identical to Cytotoxic T-lymphocyte antigen-2 alpha (CTLA-2α) which is also shown to exhibit selective inhibitory activities against cathepsin L. However, the specific cell types synthesizing CTLA-2α in mouse adenohypophysis and its functional implications as relevant in vivo have not been demonstrated. In this study, CTLA-2α expression in the adenohypophysis was evaluated by immunohistochemistry. In both male and female mice, strong immunoreactivity was specifically detected in folliculostellate (FS) cells surrounding endocrine cells which were delineated by CTLA-2α. These findings suggest that CTLA-2α may be involved in the proteolytic processing and secretion of hormones in the adenohypophysis through regulation of Cathepsin L.

Key words: Mouse, Adenohypophysis, CTLA-2α, Immunohistochemistry


 
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Pubmed Style

Luziga C, . Potential role of Cytotoxic T-Lymphocyte Antigen 2 alpha in secretory activity of endocrine cells in mouse adenohyphphysis . Open Vet J. 2019; 9(2): 114-119. doi:10.4314/ovj.v9i2.4


Web Style

Luziga C, . Potential role of Cytotoxic T-Lymphocyte Antigen 2 alpha in secretory activity of endocrine cells in mouse adenohyphphysis . https://www.openveterinaryjournal.com/?mno=12340 [Access: June 22, 2024]. doi:10.4314/ovj.v9i2.4


AMA (American Medical Association) Style

Luziga C, . Potential role of Cytotoxic T-Lymphocyte Antigen 2 alpha in secretory activity of endocrine cells in mouse adenohyphphysis . Open Vet J. 2019; 9(2): 114-119. doi:10.4314/ovj.v9i2.4



Vancouver/ICMJE Style

Luziga C, . Potential role of Cytotoxic T-Lymphocyte Antigen 2 alpha in secretory activity of endocrine cells in mouse adenohyphphysis . Open Vet J. (2019), [cited June 22, 2024]; 9(2): 114-119. doi:10.4314/ovj.v9i2.4



Harvard Style

Luziga, C. . & (2019) Potential role of Cytotoxic T-Lymphocyte Antigen 2 alpha in secretory activity of endocrine cells in mouse adenohyphphysis . Open Vet J, 9 (2), 114-119. doi:10.4314/ovj.v9i2.4



Turabian Style

Luziga, Claudius , and . 2019. Potential role of Cytotoxic T-Lymphocyte Antigen 2 alpha in secretory activity of endocrine cells in mouse adenohyphphysis . Open Veterinary Journal, 9 (2), 114-119. doi:10.4314/ovj.v9i2.4



Chicago Style

Luziga, Claudius , and . "Potential role of Cytotoxic T-Lymphocyte Antigen 2 alpha in secretory activity of endocrine cells in mouse adenohyphphysis ." Open Veterinary Journal 9 (2019), 114-119. doi:10.4314/ovj.v9i2.4



MLA (The Modern Language Association) Style

Luziga, Claudius , and . "Potential role of Cytotoxic T-Lymphocyte Antigen 2 alpha in secretory activity of endocrine cells in mouse adenohyphphysis ." Open Veterinary Journal 9.2 (2019), 114-119. Print. doi:10.4314/ovj.v9i2.4



APA (American Psychological Association) Style

Luziga, C. . & (2019) Potential role of Cytotoxic T-Lymphocyte Antigen 2 alpha in secretory activity of endocrine cells in mouse adenohyphphysis . Open Veterinary Journal, 9 (2), 114-119. doi:10.4314/ovj.v9i2.4