Abstract
Background: Food born disease was caused by require of pathogenic bacteria like Salmonella enteritidis (S. enteritidis). It was caused intestinal imbalance. The microbial toxins could find in the gastrointestinal tract and become diarrhea as a symptom. Coffee contains by active ingredient like antioxidants that used as an anti-inflammatory by reducing pro-inflammatory cytokines levels in the body.
Aim: The purpose of the study was determined the interaction between Lampung robust coffee and tissue damage in the infected chicken by S. enteritidis.
Methods: This study used 60 first-day old layer, strain Isa brown. The treatment consisted of negative control (healthy and normal chicken), positive control (infected with S. enteritidis bacteria with concentrations of 108 CFU /ml), T1, T2 and T3 (chickens were given coffee extract with low-moderate-high dose, consecutive doses of 500 mg / kg bw, 1000 mg / kg bw and 1500 mg / kg bw then infected with S. enteritidis bacteria with a concentration of 108 CFU /ml. The extract coffee and bacteria were given by feeding tube with a volume of 0.5 ml per chicks. The extract was giving of 14 days, on days 3-16 and the bacteria on days 17-18. The necropsy did on days 20. The analyze of Malondialdehyde (MDA) level was used One Way ANOVA test with GLM procedure (<0.05). While, the histopathology of intestine damage was analyzed by qualitative descriptive.
Result: The results had shown that MDA levels (nmol/L) decrease in treatment groups T1, T2 and T3. Whereas, the histopathological result was repaired in T1 and T2 group. Which is show the form of normal and regular intestinal epithelium arrangement of the ileum and long intestinal villi, and also decreased the total of leucocyte.
Conclusion: Green coffee robust had a potential to increasing antioxidant and reducing inflammation in the small intestine on chicken infected by S. enteritidis.

Key words: Layer chicks, antioxidants, green coffee, enteric bacteria