E-ISSN 2218-6050 | ISSN 2226-4485
 

Original Article


Correlation of serum kisspeptin levels, ovarian kisspeptin expression, and ovarian BMP15 expression in rat model of polycystic ovarian syndrome

Achmad Rheza, Budi Santoso, Widjiati Widjiati.


Cited By:1

Abstract
Background:
Kisspeptin is a neuropeptide that has an important role in the female reproductive cycle which is indicated by its role in regulating the hypothalamic-pituitary-gonadal axis (HPG axis).
Aims:
To analyze the correlation between serum kisspeptin levels, ovarian kisspeptin expression, and ovarian BMP15 expression in PCOS model rats.
Methods:
The research was true experimental research with post-test design only control group, was carried out from August to October 2022 at the Faculty of Veterinary Medicine Universitas Airlangga. 32 Rattus novergicus rats were divided into a control group and PCOS model group. Blood serum and ovaries were obtained from all groups. Blood serum was examined for kisspeptin levels by ELISA technique, kisspeptin expression, and BMP15 Ovaries were examined immunihistochemically.
Results:
Serum kisspeptin levels and ovarian kisspeptin expression of the PCOS model group were not significantly higher than those of the control group (p>0.05, p>0.05). The ovarian BMP15 expression of the PCOS model group was not significantly lower (p>0.05) than that of the control group. Ovarian kisspeptin expression and ovarian BMP15 expression did not have a significant correlation with serum kisspeptin levels (p>0.05). In contrast, there was a significant correlation (p<0.05) between ovarian kisspeptin expression and ovarian BMP15 expression.
Conclusion:
Serum kisspeptin levels and ovarian kisspeptin expression of the PCOS model group were not higher than those of the control group and the ovarian BMP15 expression of the PCOS model group was not lower than that of the control group. There was no correlation between serum kisspeptin levels with ovarian kisspeptin expression and ovarian BMP15 expression. A significant correlation was found between ovarian kisspeptin expression and ovarian BMP15 expression.

Key words: BMP15, Kisspeptin, Oocyte quality, PCOS, Reproductive health


 
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How to Cite this Article
Pubmed Style

Rheza A, Santoso B, Widjiati W. Correlation of serum kisspeptin levels, ovarian kisspeptin expression, and ovarian BMP15 expression in rat model of polycystic ovarian syndrome. Open Vet J. 2023; 13(3): 288-296. doi:10.5455/OVJ.2023.v13.i3.5


Web Style

Rheza A, Santoso B, Widjiati W. Correlation of serum kisspeptin levels, ovarian kisspeptin expression, and ovarian BMP15 expression in rat model of polycystic ovarian syndrome. https://www.openveterinaryjournal.com/?mno=125648 [Access: February 13, 2024]. doi:10.5455/OVJ.2023.v13.i3.5


AMA (American Medical Association) Style

Rheza A, Santoso B, Widjiati W. Correlation of serum kisspeptin levels, ovarian kisspeptin expression, and ovarian BMP15 expression in rat model of polycystic ovarian syndrome. Open Vet J. 2023; 13(3): 288-296. doi:10.5455/OVJ.2023.v13.i3.5



Vancouver/ICMJE Style

Rheza A, Santoso B, Widjiati W. Correlation of serum kisspeptin levels, ovarian kisspeptin expression, and ovarian BMP15 expression in rat model of polycystic ovarian syndrome. Open Vet J. (2023), [cited February 13, 2024]; 13(3): 288-296. doi:10.5455/OVJ.2023.v13.i3.5



Harvard Style

Rheza, A., Santoso, . B. & Widjiati, . W. (2023) Correlation of serum kisspeptin levels, ovarian kisspeptin expression, and ovarian BMP15 expression in rat model of polycystic ovarian syndrome. Open Vet J, 13 (3), 288-296. doi:10.5455/OVJ.2023.v13.i3.5



Turabian Style

Rheza, Achmad, Budi Santoso, and Widjiati Widjiati. 2023. Correlation of serum kisspeptin levels, ovarian kisspeptin expression, and ovarian BMP15 expression in rat model of polycystic ovarian syndrome. Open Veterinary Journal, 13 (3), 288-296. doi:10.5455/OVJ.2023.v13.i3.5



Chicago Style

Rheza, Achmad, Budi Santoso, and Widjiati Widjiati. "Correlation of serum kisspeptin levels, ovarian kisspeptin expression, and ovarian BMP15 expression in rat model of polycystic ovarian syndrome." Open Veterinary Journal 13 (2023), 288-296. doi:10.5455/OVJ.2023.v13.i3.5



MLA (The Modern Language Association) Style

Rheza, Achmad, Budi Santoso, and Widjiati Widjiati. "Correlation of serum kisspeptin levels, ovarian kisspeptin expression, and ovarian BMP15 expression in rat model of polycystic ovarian syndrome." Open Veterinary Journal 13.3 (2023), 288-296. Print. doi:10.5455/OVJ.2023.v13.i3.5



APA (American Psychological Association) Style

Rheza, A., Santoso, . B. & Widjiati, . W. (2023) Correlation of serum kisspeptin levels, ovarian kisspeptin expression, and ovarian BMP15 expression in rat model of polycystic ovarian syndrome. Open Veterinary Journal, 13 (3), 288-296. doi:10.5455/OVJ.2023.v13.i3.5