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Online Published: 13 Nov 2022


Glycosaminoglycans and their precursors in osteoarthritis

Sergei V. Jargin.


Abstract
Chondroitin (Ch) is a glycosaminoglycan (GAG); and glucosamine (Ga) is an aminosaccharide acting as a substrate for biosynthesis of GAG. Ch undergoes hydrolysis in the intestine; being administered orally, it can also be regarded as a source of precursors for GAG. Hyaluronic acid (HA) is a GAG used for intra-articular injections. These substances are applied for the treatment of osteoarthritis and named chondroprotectants or chondroprotectives. The oral GAG have been discussed within the group of Symptomatic Slow-Acting Drugs in Osteoarthritis (SYSADOA) (Bruyère et al., 2016), which is hardly justified: these drugs are supposed to act primarily not upon symptoms but upon the pathogenesis – to compensate for a deficiency of cartilage constituents.

Key words: Glycosaminoglycans, Precursors, Osteoarthritis


 
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Pubmed Style

Sergei V. Jargin. Glycosaminoglycans and their precursors in osteoarthritis. Open Vet J. 2018; 0(0): -.

Web Style

Sergei V. Jargin. Glycosaminoglycans and their precursors in osteoarthritis. https://www.openveterinaryjournal.com/?mno=129518 [Access: December 03, 2024].

AMA (American Medical Association) Style

Sergei V. Jargin. Glycosaminoglycans and their precursors in osteoarthritis. Open Vet J. 2018; 0(0): -.


Vancouver/ICMJE Style

Sergei V. Jargin. Glycosaminoglycans and their precursors in osteoarthritis. Open Vet J. (2018), [cited December 03, 2024]; 0(0): -.


Harvard Style

Sergei V. Jargin (2018) Glycosaminoglycans and their precursors in osteoarthritis. Open Vet J, 0 (0), -.


Turabian Style

Sergei V. Jargin. 2018. Glycosaminoglycans and their precursors in osteoarthritis. Open Veterinary Journal, 0 (0), -.


Chicago Style

Sergei V. Jargin. "Glycosaminoglycans and their precursors in osteoarthritis." Open Veterinary Journal 0 (2018), -.


MLA (The Modern Language Association) Style

Sergei V. Jargin. "Glycosaminoglycans and their precursors in osteoarthritis." Open Veterinary Journal 0.0 (2018), -. Print.


APA (American Psychological Association) Style

Sergei V. Jargin (2018) Glycosaminoglycans and their precursors in osteoarthritis. Open Veterinary Journal, 0 (0), -.


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