E-ISSN 2218-6050 | ISSN 2226-4485
 

Research Article


Effects of glutamine and arginine combination on pro- and anti-inflammatory cytokines

Maulydia Maulydia, Nancy Margarita Rehatta, Subijanto Marto Sudarmo.


Abstract
Background:
Cytokines were beneficial for diagnosis and treatment, which in clinical situation introduced from the perspective of pro- and anti-inflammatory effects. Inflammatory response commonly associated with various severe traumatic insults that consequently recruit the immune cells into the target organs and causing SIRS that can lead into sepsis. Immune-modulating nutrients such as glutamine and arginine, known as pathophysiological modulate in inflammation.
Aim:
The aim of this study was to evaluate the effect of oral gavage supplementation with a combination of glutamine and arginine on inflammatory cytokines at intestinal mucosa, specifically jejunum.
Methods:
Sixteen Rattus norvegicus rats (average weight 150-200 g) were randomly divided into two groups: groups A and B, both intraperitoneal injected by 2 mL NaCl 0.9%. Group A orally supplemented with 1 mL dextrose 5% daily, meanwhile group B orally supplemented with 1 mL combination of glutamine and arginine (contain 250 mg/kg glutamine and 250 mg/kg arginine) daily. The experiment lasted for 3 days. We compared the pro- and anti-inflammatory cytokines (IL-10, NF-kB, TNF-α, IL-8, and MMP-8) between the two groups by Mann-Whitney test.
Results:
More IL-10, TNF-α, and IL-8 cytokine produced cells found in group A. Group B produced significantly lower TNF-α (p=0.009) and IL-8 (p=0.003). The number of NF-B and MMP-8 was slightly higher in group B.
Conclusion:
Giving combination of glutamine and arginine as nutrition supplementation have beneficial effects in decreasing almost half of cells that produce TNF-α and IL-8. Further studies must be carried out to support a standard guideline for this recommendation.

Key words: Immunonutrient, Glutamine, Arginine, Inflammatory, Cytokine


 
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How to Cite this Article
Pubmed Style

Maulydia M, Rehatta NM, Sudarmo SM. Effects of glutamine and arginine combination on pro- and anti-inflammatory cytokines. Open Vet J. 2023; 13(5): 613-619. doi:10.5455/OVJ.2023.v13.i5.14


Web Style

Maulydia M, Rehatta NM, Sudarmo SM. Effects of glutamine and arginine combination on pro- and anti-inflammatory cytokines. https://www.openveterinaryjournal.com/?mno=143623 [Access: April 09, 2024]. doi:10.5455/OVJ.2023.v13.i5.14


AMA (American Medical Association) Style

Maulydia M, Rehatta NM, Sudarmo SM. Effects of glutamine and arginine combination on pro- and anti-inflammatory cytokines. Open Vet J. 2023; 13(5): 613-619. doi:10.5455/OVJ.2023.v13.i5.14



Vancouver/ICMJE Style

Maulydia M, Rehatta NM, Sudarmo SM. Effects of glutamine and arginine combination on pro- and anti-inflammatory cytokines. Open Vet J. (2023), [cited April 09, 2024]; 13(5): 613-619. doi:10.5455/OVJ.2023.v13.i5.14



Harvard Style

Maulydia, M., Rehatta, . N. M. & Sudarmo, . S. M. (2023) Effects of glutamine and arginine combination on pro- and anti-inflammatory cytokines. Open Vet J, 13 (5), 613-619. doi:10.5455/OVJ.2023.v13.i5.14



Turabian Style

Maulydia, Maulydia, Nancy Margarita Rehatta, and Subijanto Marto Sudarmo. 2023. Effects of glutamine and arginine combination on pro- and anti-inflammatory cytokines. Open Veterinary Journal, 13 (5), 613-619. doi:10.5455/OVJ.2023.v13.i5.14



Chicago Style

Maulydia, Maulydia, Nancy Margarita Rehatta, and Subijanto Marto Sudarmo. "Effects of glutamine and arginine combination on pro- and anti-inflammatory cytokines." Open Veterinary Journal 13 (2023), 613-619. doi:10.5455/OVJ.2023.v13.i5.14



MLA (The Modern Language Association) Style

Maulydia, Maulydia, Nancy Margarita Rehatta, and Subijanto Marto Sudarmo. "Effects of glutamine and arginine combination on pro- and anti-inflammatory cytokines." Open Veterinary Journal 13.5 (2023), 613-619. Print. doi:10.5455/OVJ.2023.v13.i5.14



APA (American Psychological Association) Style

Maulydia, M., Rehatta, . N. M. & Sudarmo, . S. M. (2023) Effects of glutamine and arginine combination on pro- and anti-inflammatory cytokines. Open Veterinary Journal, 13 (5), 613-619. doi:10.5455/OVJ.2023.v13.i5.14