Abstract
To the editor: We read the article entitled “Development of unconventional treatments for mastitis in dairy cattle” with great interest.
Bovine mastitis is an inflammatory reaction of the udder tissue in the mammary gland initiated due to physical trauma or microorganism infections. As a direct effect of mastitis, there are significant economic losses due to decreased milk production and quality. It can also cause devastating effects on the finances of ruminant farms (Ashraf and Imran, 2018). This paper aimed to develop and evaluate a new therapeutic approach to treat subclinical bovine mastitis without antibiotics, as the authors wrote: “antibiotic-free”, with plant extracts. We congratulate the authors for this original and innovative article and make some comments concerning our knowledge about mastitis and the therapeutic evaluation of natural extracts in animal models. First, we must clarify that the most common route of drug administration for bovine mastitis is not “intrauterine antibiotic infusion”, as the authors wrote, but is the intra-mammary application of antibiotics and non-steroid anti-inflammatory drugs.

Key words: Mastitis, Dairy cattle, Mammary gland