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Research Article


Effects of high-dose docosahexaenoic acid supplementation as an add-on therapy for canine idiopathic epilepsy: A pilot study

Tomohiro Yonezawa, Cris Niño Bon B. Marasigan, Yuki Matsumiya, Shingo Maeda, Tomoki Motegi, Yasuyuki Momoi.


Abstract
Background:
The anti-epileptic effects of docosahexaenoic acid (DHA) in dogs and humans remain controversial. The dosage and efficacy of DHA were various in the previous reports.
Aim:
The effects of high-dose DHA supplementation as add-on therapy for idiopathic epilepsy in dogs were evaluated.
Methods:
An open-label clinical trial was designed in this pilot study. Six dogs (median age: 6 years) with idiopathic epilepsy were included. All the patients were diagnosed with idiopathic epilepsy using magnetic MRI and cerebrospinal fluid examination (median: 2.0 years before the trial). They had 5–45 seizures and/or auras (median: 9.0) in the month before starting DHA supplementation. DHA was adjunctively administered at doses of 69–166 mg/kg/day without changing other prescriptions.
Results:
Four of the six patients completed the 6-month observation period. All the patients showed a decrease in seizure frequency of 50% or more within 2–3 months after the start of the administration, and three patients decreased to a frequency of 0–1 per month after 5–6 months. No clear adverse events were observed in the general condition or blood test results in any patients.
Conclusion:
Although the sample size was small and the study was not a randomized controlled trial, the data suggest that add-on supplementation of DHA could be useful in reducing the frequency of seizures in canine idiopathic epilepsy.

Key words: Docosahexaenoic acid, Dogs, Drug-resistant epilepsy, Idiopathic epilepsy, Omega-3 fatty acids


 
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How to Cite this Article
Pubmed Style

Yonezawa T, Marasigan CNBB, Matsumiya Y, Maeda S, Motegi T, Momoi Y. Effects of high-dose docosahexaenoic acid supplementation as an add-on therapy for canine idiopathic epilepsy: A pilot study. Open Vet J. 2023; 13(7): 942-947. doi:10.5455/OVJ.2023.v13.i7.14

Web Style

Yonezawa T, Marasigan CNBB, Matsumiya Y, Maeda S, Motegi T, Momoi Y. Effects of high-dose docosahexaenoic acid supplementation as an add-on therapy for canine idiopathic epilepsy: A pilot study. https://www.openveterinaryjournal.com/?mno=147025 [Access: May 02, 2024]. doi:10.5455/OVJ.2023.v13.i7.14

AMA (American Medical Association) Style

Yonezawa T, Marasigan CNBB, Matsumiya Y, Maeda S, Motegi T, Momoi Y. Effects of high-dose docosahexaenoic acid supplementation as an add-on therapy for canine idiopathic epilepsy: A pilot study. Open Vet J. 2023; 13(7): 942-947. doi:10.5455/OVJ.2023.v13.i7.14


Vancouver/ICMJE Style

Yonezawa T, Marasigan CNBB, Matsumiya Y, Maeda S, Motegi T, Momoi Y. Effects of high-dose docosahexaenoic acid supplementation as an add-on therapy for canine idiopathic epilepsy: A pilot study. Open Vet J. (2023), [cited May 02, 2024]; 13(7): 942-947. doi:10.5455/OVJ.2023.v13.i7.14


Harvard Style

Yonezawa, T., Marasigan, . C. N. B. B., Matsumiya, . Y., Maeda, . S., Motegi, . T. & Momoi, . Y. (2023) Effects of high-dose docosahexaenoic acid supplementation as an add-on therapy for canine idiopathic epilepsy: A pilot study. Open Vet J, 13 (7), 942-947. doi:10.5455/OVJ.2023.v13.i7.14


Turabian Style

Yonezawa, Tomohiro, Cris Niño Bon B. Marasigan, Yuki Matsumiya, Shingo Maeda, Tomoki Motegi, and Yasuyuki Momoi. 2023. Effects of high-dose docosahexaenoic acid supplementation as an add-on therapy for canine idiopathic epilepsy: A pilot study. Open Veterinary Journal, 13 (7), 942-947. doi:10.5455/OVJ.2023.v13.i7.14


Chicago Style

Yonezawa, Tomohiro, Cris Niño Bon B. Marasigan, Yuki Matsumiya, Shingo Maeda, Tomoki Motegi, and Yasuyuki Momoi. "Effects of high-dose docosahexaenoic acid supplementation as an add-on therapy for canine idiopathic epilepsy: A pilot study." Open Veterinary Journal 13 (2023), 942-947. doi:10.5455/OVJ.2023.v13.i7.14


MLA (The Modern Language Association) Style

Yonezawa, Tomohiro, Cris Niño Bon B. Marasigan, Yuki Matsumiya, Shingo Maeda, Tomoki Motegi, and Yasuyuki Momoi. "Effects of high-dose docosahexaenoic acid supplementation as an add-on therapy for canine idiopathic epilepsy: A pilot study." Open Veterinary Journal 13.7 (2023), 942-947. Print. doi:10.5455/OVJ.2023.v13.i7.14


APA (American Psychological Association) Style

Yonezawa, T., Marasigan, . C. N. B. B., Matsumiya, . Y., Maeda, . S., Motegi, . T. & Momoi, . Y. (2023) Effects of high-dose docosahexaenoic acid supplementation as an add-on therapy for canine idiopathic epilepsy: A pilot study. Open Veterinary Journal, 13 (7), 942-947. doi:10.5455/OVJ.2023.v13.i7.14


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