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The impact of Apis dorsata forest honey administration on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in rats (Rattus norvegicus) forced swim test as a chronic physical animal model

Widjiati Widjiati, Epy Muhammad Luqman, Suryo Kuntjorodjakti, Aulanni’am Aulanni’am, Zahra Shabira, Sultan Fadhilla Taqwa, Riski Lesta Mega, Dean Chou, Ahmad Shofy Mubarak, Viski Fitri Hendrawan.


Abstract
Background:
Chronic physical stress has many effects on the nervous system and can cause structural changes in different parts of the brain and hemomodulatory, including hormonal. Current pharmacotherapeutic treatments have limited efficacy and are associated with many deleterious side effects
Aim:
The aim of this research is to determine how apis dorsata forest honey administration affects FSH and LH levels in rats who are subjected to forced swim tests as a model of chronic physical stress placed in a container filled with water from which it cannot escape.
Methods:
This was an experimental laboratory study with 32 rats divided into four treatment groups: control (C), Treatment 1 (T1) with a forced swim test + honey (2 g/rat/day), Treatment 2 (T2) with a forced swim test + honey (4 g/rat/day), and Treatment 3 (T3) with a forced swim test + honey (6 g/rat/day). All treatments were administered for 14 days. Then blood was taken for FSH and LH serum tests, and a one-way ANOVA and Duncan test were used to statistically test the data analysis.
Results:
The results of this study indicate that the administration of forest honey had no significant effect (p > 0.05) on the FSH parameter, but there was a significant decrease in LH levels in the T2 and T3 groups (p<0.05).
Conclusion:
It can be concluded that giving forest honey to rats who were subjected to a 14-day forced swim test had no effect on FSH and LH levels. In rats given a forced swim test as a model of chronic stress, administration at doses of 4 g/rat/day and 6 g/rat/day reduced LH serum levels.

Key words: Rattus norvegicus, Forced swim test, Apis dorsata forest honey, FSH, LH


 
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How to Cite this Article
Pubmed Style

Widjiati W, Luqman EM, Kuntjorodjakti S, Aulanni'am A, Shabira Z, Taqwa SF, Mega RL, Chou D, Mubarak AS, Hendrawan VF. The impact of Apis dorsata forest honey administration on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in rats (Rattus norvegicus) forced swim test as a chronic physical animal model. Open Vet J. 2024; 14(2): 738-742. doi:10.5455/OVJ.2024.v14.i2.14


Web Style

Widjiati W, Luqman EM, Kuntjorodjakti S, Aulanni'am A, Shabira Z, Taqwa SF, Mega RL, Chou D, Mubarak AS, Hendrawan VF. The impact of Apis dorsata forest honey administration on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in rats (Rattus norvegicus) forced swim test as a chronic physical animal model. https://www.openveterinaryjournal.com/?mno=174251 [Access: April 09, 2024]. doi:10.5455/OVJ.2024.v14.i2.14


AMA (American Medical Association) Style

Widjiati W, Luqman EM, Kuntjorodjakti S, Aulanni'am A, Shabira Z, Taqwa SF, Mega RL, Chou D, Mubarak AS, Hendrawan VF. The impact of Apis dorsata forest honey administration on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in rats (Rattus norvegicus) forced swim test as a chronic physical animal model. Open Vet J. 2024; 14(2): 738-742. doi:10.5455/OVJ.2024.v14.i2.14



Vancouver/ICMJE Style

Widjiati W, Luqman EM, Kuntjorodjakti S, Aulanni'am A, Shabira Z, Taqwa SF, Mega RL, Chou D, Mubarak AS, Hendrawan VF. The impact of Apis dorsata forest honey administration on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in rats (Rattus norvegicus) forced swim test as a chronic physical animal model. Open Vet J. (2024), [cited April 09, 2024]; 14(2): 738-742. doi:10.5455/OVJ.2024.v14.i2.14



Harvard Style

Widjiati, W., Luqman, . E. M., Kuntjorodjakti, . S., Aulanni'am, . A., Shabira, . Z., Taqwa, . S. F., Mega, . R. L., Chou, . D., Mubarak, . A. S. & Hendrawan, . V. F. (2024) The impact of Apis dorsata forest honey administration on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in rats (Rattus norvegicus) forced swim test as a chronic physical animal model. Open Vet J, 14 (2), 738-742. doi:10.5455/OVJ.2024.v14.i2.14



Turabian Style

Widjiati, Widjiati, Epy Muhammad Luqman, Suryo Kuntjorodjakti, Aulanni'am Aulanni'am, Zahra Shabira, Sultan Fadhilla Taqwa, Riski Lesta Mega, Dean Chou, Ahmad Shofy Mubarak, and Viski Fitri Hendrawan. 2024. The impact of Apis dorsata forest honey administration on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in rats (Rattus norvegicus) forced swim test as a chronic physical animal model. Open Veterinary Journal, 14 (2), 738-742. doi:10.5455/OVJ.2024.v14.i2.14



Chicago Style

Widjiati, Widjiati, Epy Muhammad Luqman, Suryo Kuntjorodjakti, Aulanni'am Aulanni'am, Zahra Shabira, Sultan Fadhilla Taqwa, Riski Lesta Mega, Dean Chou, Ahmad Shofy Mubarak, and Viski Fitri Hendrawan. "The impact of Apis dorsata forest honey administration on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in rats (Rattus norvegicus) forced swim test as a chronic physical animal model." Open Veterinary Journal 14 (2024), 738-742. doi:10.5455/OVJ.2024.v14.i2.14



MLA (The Modern Language Association) Style

Widjiati, Widjiati, Epy Muhammad Luqman, Suryo Kuntjorodjakti, Aulanni'am Aulanni'am, Zahra Shabira, Sultan Fadhilla Taqwa, Riski Lesta Mega, Dean Chou, Ahmad Shofy Mubarak, and Viski Fitri Hendrawan. "The impact of Apis dorsata forest honey administration on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in rats (Rattus norvegicus) forced swim test as a chronic physical animal model." Open Veterinary Journal 14.2 (2024), 738-742. Print. doi:10.5455/OVJ.2024.v14.i2.14



APA (American Psychological Association) Style

Widjiati, W., Luqman, . E. M., Kuntjorodjakti, . S., Aulanni'am, . A., Shabira, . Z., Taqwa, . S. F., Mega, . R. L., Chou, . D., Mubarak, . A. S. & Hendrawan, . V. F. (2024) The impact of Apis dorsata forest honey administration on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in rats (Rattus norvegicus) forced swim test as a chronic physical animal model. Open Veterinary Journal, 14 (2), 738-742. doi:10.5455/OVJ.2024.v14.i2.14