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Research Article


Antidiabetic, antidyslipidemia and renoprotector potency of butterfly pea flower extract (Clitorea ternatea L.) in diabetes mellitus and dyslipidemia rats model

Wahyu Widowati, Lusiana Darsono, Maria R. Natariza, Novaldo W. Waluyo, Abigail M. Gleyriena Tenda, Berlian H. Siahaan, Reza Oktaviani, Fadhilah Haifa Zahiroh, Herry S. Utomo, Rizal Rizal.


Abstract
Background:
Diabetes Mellitus (DM) is a long-term condition marked by high blood glucose levels caused by insulin resistance which will lead to complications of other diseases such as dyslipidemia which also affects the health of the liver and kidneys. Butterfly Pea Flower (Clitorea ternatea L.) has phenolic and flavonoid compounds which have the potential as herbal medicines for antidiabetics.
Aim:
The purpose of this study is to examine the potential of Butterfly Pea Flower Extract (BPE) as an antidiabetic, anti-dyslipidemia, and renoprotection.
Methods:
In vivo test was performed on Sprague Dawley rats (Rattus norvegicus L.) induced by Streptozotocin-Nicotinamide and High Fat Diet-Propylthiouracil as models of DM and dyslipidemia, and BPE was administered orally (200, 400, and 800 mg /kg BW) for 28 days. GSH-Px, GST, TNF-α, NF-kB, ALP, liver albumin levels, serum BUN, SCr, and serum UA, were measured by ELISA and colorimetry methods.
Results:
Treatment of BPE 800 mg/kg BW increase levels of GSH-Px, GST, albumin, and serum protein. BPE decreases TNF-α, NF-kB, and ALP. BPE also decreases BUN, serum CR, and serum UA.
Conclusion:
BPE has the potential to be used as a drug alternative for the treatment of diabetes mellitus and dyslipidemia as well as a hepatoprotective and renoprotective agent.

Key words: Antidiabetic, Clitorea ternatea L., Diabetes mellitus, Dyslipidemia, Renoprotective


 
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How to Cite this Article
Pubmed Style

Widowati W, Darsono L, Natariza MR, Waluyo NW, Tenda AMG, Siahaan BH, Oktaviani R, Zahiroh FH, Utomo HS, Rizal R. Antidiabetic, antidyslipidemia and renoprotector potency of butterfly pea flower extract (Clitorea ternatea L.) in diabetes mellitus and dyslipidemia rats model. Open Vet J. 2024; 14(5): 1135-1145. doi:10.5455/OVJ.2024.v14.i5.7


Web Style

Widowati W, Darsono L, Natariza MR, Waluyo NW, Tenda AMG, Siahaan BH, Oktaviani R, Zahiroh FH, Utomo HS, Rizal R. Antidiabetic, antidyslipidemia and renoprotector potency of butterfly pea flower extract (Clitorea ternatea L.) in diabetes mellitus and dyslipidemia rats model. https://www.openveterinaryjournal.com/?mno=187755 [Access: June 04, 2024]. doi:10.5455/OVJ.2024.v14.i5.7


AMA (American Medical Association) Style

Widowati W, Darsono L, Natariza MR, Waluyo NW, Tenda AMG, Siahaan BH, Oktaviani R, Zahiroh FH, Utomo HS, Rizal R. Antidiabetic, antidyslipidemia and renoprotector potency of butterfly pea flower extract (Clitorea ternatea L.) in diabetes mellitus and dyslipidemia rats model. Open Vet J. 2024; 14(5): 1135-1145. doi:10.5455/OVJ.2024.v14.i5.7



Vancouver/ICMJE Style

Widowati W, Darsono L, Natariza MR, Waluyo NW, Tenda AMG, Siahaan BH, Oktaviani R, Zahiroh FH, Utomo HS, Rizal R. Antidiabetic, antidyslipidemia and renoprotector potency of butterfly pea flower extract (Clitorea ternatea L.) in diabetes mellitus and dyslipidemia rats model. Open Vet J. (2024), [cited June 04, 2024]; 14(5): 1135-1145. doi:10.5455/OVJ.2024.v14.i5.7



Harvard Style

Widowati, W., Darsono, . L., Natariza, . M. R., Waluyo, . N. W., Tenda, . A. M. G., Siahaan, . B. H., Oktaviani, . R., Zahiroh, . F. H., Utomo, . H. S. & Rizal, . R. (2024) Antidiabetic, antidyslipidemia and renoprotector potency of butterfly pea flower extract (Clitorea ternatea L.) in diabetes mellitus and dyslipidemia rats model. Open Vet J, 14 (5), 1135-1145. doi:10.5455/OVJ.2024.v14.i5.7



Turabian Style

Widowati, Wahyu, Lusiana Darsono, Maria R. Natariza, Novaldo W. Waluyo, Abigail M. Gleyriena Tenda, Berlian H. Siahaan, Reza Oktaviani, Fadhilah Haifa Zahiroh, Herry S. Utomo, and Rizal Rizal. 2024. Antidiabetic, antidyslipidemia and renoprotector potency of butterfly pea flower extract (Clitorea ternatea L.) in diabetes mellitus and dyslipidemia rats model. Open Veterinary Journal, 14 (5), 1135-1145. doi:10.5455/OVJ.2024.v14.i5.7



Chicago Style

Widowati, Wahyu, Lusiana Darsono, Maria R. Natariza, Novaldo W. Waluyo, Abigail M. Gleyriena Tenda, Berlian H. Siahaan, Reza Oktaviani, Fadhilah Haifa Zahiroh, Herry S. Utomo, and Rizal Rizal. "Antidiabetic, antidyslipidemia and renoprotector potency of butterfly pea flower extract (Clitorea ternatea L.) in diabetes mellitus and dyslipidemia rats model." Open Veterinary Journal 14 (2024), 1135-1145. doi:10.5455/OVJ.2024.v14.i5.7



MLA (The Modern Language Association) Style

Widowati, Wahyu, Lusiana Darsono, Maria R. Natariza, Novaldo W. Waluyo, Abigail M. Gleyriena Tenda, Berlian H. Siahaan, Reza Oktaviani, Fadhilah Haifa Zahiroh, Herry S. Utomo, and Rizal Rizal. "Antidiabetic, antidyslipidemia and renoprotector potency of butterfly pea flower extract (Clitorea ternatea L.) in diabetes mellitus and dyslipidemia rats model." Open Veterinary Journal 14.5 (2024), 1135-1145. Print. doi:10.5455/OVJ.2024.v14.i5.7



APA (American Psychological Association) Style

Widowati, W., Darsono, . L., Natariza, . M. R., Waluyo, . N. W., Tenda, . A. M. G., Siahaan, . B. H., Oktaviani, . R., Zahiroh, . F. H., Utomo, . H. S. & Rizal, . R. (2024) Antidiabetic, antidyslipidemia and renoprotector potency of butterfly pea flower extract (Clitorea ternatea L.) in diabetes mellitus and dyslipidemia rats model. Open Veterinary Journal, 14 (5), 1135-1145. doi:10.5455/OVJ.2024.v14.i5.7