E-ISSN 2218-6050 | ISSN 2226-4485
 
2024, Vol: 14, Issue: 10
14 / 10Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

OVJ Manuscript Submission Form

Research Article


The efficacy of topically applied Sappan wood (Caesalpinia sappan L.) ethanol extract during incision wound healing in albino rats

Ricky Eka Sucita, Faisal Fikri, Agus Purnomo, Salipudin Tasil Maslamama, Muhammad Thohawi Elziyad Purnama.


Abstract
Background:
Medical manifestations in the form of incisions, burns and trauma will trigger a natural wound healing process which involves complex interactions between cells. Brazilin and other secondary metabolites found in Sappan wood have numerous bioactive qualities, including anti-inflammatory, anti-cancer, and antioxidant properties.
Aim:
This study aimed to investigate the efficacy of Sappan wood (Caesalpinia Sappan L.) ethanol extract topically on the incision wound healing of albino rats.
Methods:
Twenty male rats were randomly assigned into five groups with four replications i.e. (C-) was treated ointment-based, (C+) was treated with 10% povidone-iodine, (T1, T2, T3 groups) were treated with Sappan wood extract concentration for 6.5%, 15%, and 30%, respectively. The treatment was topically administered to wounded areas twice a day for 15 days. Wound healing was evaluated histologically as the following parameters collagen deposition, PMN, angiogenesis, and fibrosis degree using H&E staining. IL-2 level was evaluated using the ELISA method. Wound length reduction was calculated on days 8 and 15.
Results:
As a result, the 6.5% (T1), 15% (T2), and 30% (T3) Sappan wood extract groups were improved significantly (p < 0.05) compared to ointment-based (C-) and povidone-iodine (C+) groups on the collagen deposition, PMN, angiogenesis, fibrosis degree, and IL-2 level. In particular, 6.5% (T1) Sappan wood extract group was highlighted significantly (p < 0.05) compared to other groups, evidenced by the improvisation of wound healing parameters and reduction of wound length on days 8 and 15.
Conclusion:
In conclusion, a 6.5% Sappan wood extract revealed its applicability to improve incision wound healing in albino rats.

Key words: Drug safety, Incision wound, Sappan wood, Wound healing process


 
ARTICLE TOOLS
Abstract
PDF Fulltext
HTML Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Ricky Eka Sucita
Articles by Faisal Fikri
Articles by Agus Purnomo
Articles by Salipudin Tasil Maslamama
Articles by Muhammad Thohawi Elziyad Purnama
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Sucita RE, Fikri F, Purnomo A, Maslamama ST, Purnama MTE. The efficacy of topically applied Sappan wood (Caesalpinia sappan L.) ethanol extract during incision wound healing in albino rats. Open Vet J. 2024; 14(7): 1561-1567. doi:10.5455/OVJ.2024.v14.i7.5

Web Style

Sucita RE, Fikri F, Purnomo A, Maslamama ST, Purnama MTE. The efficacy of topically applied Sappan wood (Caesalpinia sappan L.) ethanol extract during incision wound healing in albino rats. https://www.openveterinaryjournal.com/?mno=196045 [Access: November 07, 2024]. doi:10.5455/OVJ.2024.v14.i7.5

AMA (American Medical Association) Style

Sucita RE, Fikri F, Purnomo A, Maslamama ST, Purnama MTE. The efficacy of topically applied Sappan wood (Caesalpinia sappan L.) ethanol extract during incision wound healing in albino rats. Open Vet J. 2024; 14(7): 1561-1567. doi:10.5455/OVJ.2024.v14.i7.5


Vancouver/ICMJE Style

Sucita RE, Fikri F, Purnomo A, Maslamama ST, Purnama MTE. The efficacy of topically applied Sappan wood (Caesalpinia sappan L.) ethanol extract during incision wound healing in albino rats. Open Vet J. (2024), [cited November 07, 2024]; 14(7): 1561-1567. doi:10.5455/OVJ.2024.v14.i7.5


Harvard Style

Sucita, R. E., Fikri, . F., Purnomo, . A., Maslamama, . S. T. & Purnama, . M. T. E. (2024) The efficacy of topically applied Sappan wood (Caesalpinia sappan L.) ethanol extract during incision wound healing in albino rats. Open Vet J, 14 (7), 1561-1567. doi:10.5455/OVJ.2024.v14.i7.5


Turabian Style

Sucita, Ricky Eka, Faisal Fikri, Agus Purnomo, Salipudin Tasil Maslamama, and Muhammad Thohawi Elziyad Purnama. 2024. The efficacy of topically applied Sappan wood (Caesalpinia sappan L.) ethanol extract during incision wound healing in albino rats. Open Veterinary Journal, 14 (7), 1561-1567. doi:10.5455/OVJ.2024.v14.i7.5


Chicago Style

Sucita, Ricky Eka, Faisal Fikri, Agus Purnomo, Salipudin Tasil Maslamama, and Muhammad Thohawi Elziyad Purnama. "The efficacy of topically applied Sappan wood (Caesalpinia sappan L.) ethanol extract during incision wound healing in albino rats." Open Veterinary Journal 14 (2024), 1561-1567. doi:10.5455/OVJ.2024.v14.i7.5


MLA (The Modern Language Association) Style

Sucita, Ricky Eka, Faisal Fikri, Agus Purnomo, Salipudin Tasil Maslamama, and Muhammad Thohawi Elziyad Purnama. "The efficacy of topically applied Sappan wood (Caesalpinia sappan L.) ethanol extract during incision wound healing in albino rats." Open Veterinary Journal 14.7 (2024), 1561-1567. Print. doi:10.5455/OVJ.2024.v14.i7.5


APA (American Psychological Association) Style

Sucita, R. E., Fikri, . F., Purnomo, . A., Maslamama, . S. T. & Purnama, . M. T. E. (2024) The efficacy of topically applied Sappan wood (Caesalpinia sappan L.) ethanol extract during incision wound healing in albino rats. Open Veterinary Journal, 14 (7), 1561-1567. doi:10.5455/OVJ.2024.v14.i7.5


Author LoginReviewer LoginAbout PublisherPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyTerms of UseLicense Information

About Open Veterinary Journal

Open Veterinary Journal provides a fast track coupled with high quality peer review process for original research articles, review articles, short communi ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes: Owner, Founder and Editor-in-Chief

Open Veterinary Journal


Faculty of Veterinary Medicine, University of Tripoli

P.O. Box 13662, Tripoli, Libya

and


Eldaghayes Publisher

www.eldagpublisher.com 

Email: ibrahim.eldaghayes@vetmed.edu.ly