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2024, Vol: 14, Issue: 10
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Case Report


Therapeutic effect of nimustine in a dog with intracranial histiocytic sarcoma

Michihito Tagawa, Takamasa Itoi, Ryohei Yoshitake, Kenji Kutara, Natsuki Akashi, Ikki Mitsui, Yasuhiko Okamura.


Abstract
Background:
Intracranial histiocytic sarcoma (HS) is uncommon in dogs, and no standard treatment has yet been defined for this disease. Herein, we describe a case of intracranial HS that responded favorably to nimustine treatment.

Case Description:
A 9-year-old, castrated Welsh Corgi Pembroke presented with a two-month history of quadriplegia. Intracranial disease was suspected on neurological examination, and magnetic resonance imaging (MRI) revealed a contrast-enhanced mass in the left frontal lobe. Following tissue biopsy, the patient received intravenous nimustine (ACNU) treatment. The patient's neurological symptoms partially improved, and a reduction in tumor volume was observed on MRI on day 99. After three administrations of ACNU, tumor regrowth was confirmed on day 124, and temozolomide was subsequently administered. The patient subsequently showed no major changes in clinical symptoms, but subsequently died suddenly on day 195.

Conclusion:
In this case, administration of ACNU provided temporary symptom improvement and tumor reduction. Therefore, ACNU monotherapy may be a therapeutic option for canine intracranial HS.

Key words: ACNU, Canine, Chemotherapy, Magnetic resonance imaging


 
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How to Cite this Article
Pubmed Style

Tagawa M, Itoi T, Yoshitake R, Kutara K, Akashi N, Mitsui I, Okamura Y. Therapeutic effect of nimustine in a dog with intracranial histiocytic sarcoma. Open Vet J. 2024; 14(10): 2700-2706. doi:10.5455/OVJ.2024.v14.i10.20

Web Style

Tagawa M, Itoi T, Yoshitake R, Kutara K, Akashi N, Mitsui I, Okamura Y. Therapeutic effect of nimustine in a dog with intracranial histiocytic sarcoma. https://www.openveterinaryjournal.com/?mno=206554 [Access: October 30, 2024]. doi:10.5455/OVJ.2024.v14.i10.20

AMA (American Medical Association) Style

Tagawa M, Itoi T, Yoshitake R, Kutara K, Akashi N, Mitsui I, Okamura Y. Therapeutic effect of nimustine in a dog with intracranial histiocytic sarcoma. Open Vet J. 2024; 14(10): 2700-2706. doi:10.5455/OVJ.2024.v14.i10.20


Vancouver/ICMJE Style

Tagawa M, Itoi T, Yoshitake R, Kutara K, Akashi N, Mitsui I, Okamura Y. Therapeutic effect of nimustine in a dog with intracranial histiocytic sarcoma. Open Vet J. (2024), [cited October 30, 2024]; 14(10): 2700-2706. doi:10.5455/OVJ.2024.v14.i10.20


Harvard Style

Tagawa, M., Itoi, . T., Yoshitake, . R., Kutara, . K., Akashi, . N., Mitsui, . I. & Okamura, . Y. (2024) Therapeutic effect of nimustine in a dog with intracranial histiocytic sarcoma. Open Vet J, 14 (10), 2700-2706. doi:10.5455/OVJ.2024.v14.i10.20


Turabian Style

Tagawa, Michihito, Takamasa Itoi, Ryohei Yoshitake, Kenji Kutara, Natsuki Akashi, Ikki Mitsui, and Yasuhiko Okamura. 2024. Therapeutic effect of nimustine in a dog with intracranial histiocytic sarcoma. Open Veterinary Journal, 14 (10), 2700-2706. doi:10.5455/OVJ.2024.v14.i10.20


Chicago Style

Tagawa, Michihito, Takamasa Itoi, Ryohei Yoshitake, Kenji Kutara, Natsuki Akashi, Ikki Mitsui, and Yasuhiko Okamura. "Therapeutic effect of nimustine in a dog with intracranial histiocytic sarcoma." Open Veterinary Journal 14 (2024), 2700-2706. doi:10.5455/OVJ.2024.v14.i10.20


MLA (The Modern Language Association) Style

Tagawa, Michihito, Takamasa Itoi, Ryohei Yoshitake, Kenji Kutara, Natsuki Akashi, Ikki Mitsui, and Yasuhiko Okamura. "Therapeutic effect of nimustine in a dog with intracranial histiocytic sarcoma." Open Veterinary Journal 14.10 (2024), 2700-2706. Print. doi:10.5455/OVJ.2024.v14.i10.20


APA (American Psychological Association) Style

Tagawa, M., Itoi, . T., Yoshitake, . R., Kutara, . K., Akashi, . N., Mitsui, . I. & Okamura, . Y. (2024) Therapeutic effect of nimustine in a dog with intracranial histiocytic sarcoma. Open Veterinary Journal, 14 (10), 2700-2706. doi:10.5455/OVJ.2024.v14.i10.20


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