E-ISSN 2218-6050 | ISSN 2226-4485
 

Original Article


Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system

Joana Matos, Berenice Lutz, Lisa-Maria Grandt, Felix Meneses, Daniela Schweizer, Thierry Francey, Miguel Campos.

Abstract
Background: Hyperthyroidism is the most frequent endocrinopathy in older cats. To date, there is no consensus on how to best calculate the dose of radioiodine to administer to hyperthyroid cats.
Aim: The goals of this study were to compare thyroid function, renal function and survival time between hyperthyroid cats receiving a fixed dose of radioiodine and those receiving an individualized dose calculated using a clinical scoring system.
Methods: Medical records of 110 cats treated with radioiodine therapy at the University of Bern between 2010 and 2020 were reviewed. Thyroid function, renal function and survival of cats treated with a fixed dose of radioiodine (2010-2015; n= 50) were compared to those of cats treated with an individualized dose (2015-2020; n= 60) at different timepoints after therapy.
Results: Treatment with a fixed dose of radioiodine (mean 168 ± 26 MBq) was associated with 69% of euthyroidism, 19% persistent hyperthyroidism and 12% hypothyroidism, whereas treatment with an individualized dose (mean 120 ± 30 MBq) led to 54% euthyroidism, 23% hyperthyroidism and 23% hypothyroidism (P=0.73).
More than twelve months after treatment, the incidence of azotaemia was comparable between cats treated with a fixed dose (37%) and those treated with an individualized dose (31%) (P= 0.77).
No factors were found to be predictive of treatment failure (hypothyroidism or hyperthyroidism) after therapy.
Median survival time after radioiodine therapy was 44 months. In a multivariate analysis, persistent hyperthyroidism was the only variable independently associated with a shorter survival time (HR= 6.24, P= 0.002).
Conclusion: The method of calculating the dose of radioiodine (fixed vs individualized) to treat feline hyperthyroidism does not appear to be decisive for post-treatment thyroid function, renal function or survival.

Key words: cat; dose; hyperthyroidism; radioiodine.


 
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How to Cite this Article
Pubmed Style

Matos J, BL, Grandt L, Meneses F, Schweizer D, Francey T, Campos M. Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system. Open Vet J. 2022; 12(2): 231-241. doi:10.5455/OVJ.2022.v12.i2.11


Web Style

Matos J, BL, Grandt L, Meneses F, Schweizer D, Francey T, Campos M. Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system. https://www.openveterinaryjournal.com/?mno=21277 [Access: February 07, 2023]. doi:10.5455/OVJ.2022.v12.i2.11


AMA (American Medical Association) Style

Matos J, BL, Grandt L, Meneses F, Schweizer D, Francey T, Campos M. Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system. Open Vet J. 2022; 12(2): 231-241. doi:10.5455/OVJ.2022.v12.i2.11



Vancouver/ICMJE Style

Matos J, BL, Grandt L, Meneses F, Schweizer D, Francey T, Campos M. Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system. Open Vet J. (2022), [cited February 07, 2023]; 12(2): 231-241. doi:10.5455/OVJ.2022.v12.i2.11



Harvard Style

Matos, J., , . B. L., Grandt, . L., Meneses, . F., Schweizer, . D., Francey, . T. & Campos, . M. (2022) Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system. Open Vet J, 12 (2), 231-241. doi:10.5455/OVJ.2022.v12.i2.11



Turabian Style

Matos, Joana, Berenice Lutz, Lisa-Maria Grandt, Felix Meneses, Daniela Schweizer, Thierry Francey, and Miguel Campos. 2022. Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system. Open Veterinary Journal, 12 (2), 231-241. doi:10.5455/OVJ.2022.v12.i2.11



Chicago Style

Matos, Joana, Berenice Lutz, Lisa-Maria Grandt, Felix Meneses, Daniela Schweizer, Thierry Francey, and Miguel Campos. "Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system." Open Veterinary Journal 12 (2022), 231-241. doi:10.5455/OVJ.2022.v12.i2.11



MLA (The Modern Language Association) Style

Matos, Joana, Berenice Lutz, Lisa-Maria Grandt, Felix Meneses, Daniela Schweizer, Thierry Francey, and Miguel Campos. "Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system." Open Veterinary Journal 12.2 (2022), 231-241. Print. doi:10.5455/OVJ.2022.v12.i2.11



APA (American Psychological Association) Style

Matos, J., , . B. L., Grandt, . L., Meneses, . F., Schweizer, . D., Francey, . T. & Campos, . M. (2022) Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system. Open Veterinary Journal, 12 (2), 231-241. doi:10.5455/OVJ.2022.v12.i2.11