E-ISSN 2218-6050 | ISSN 2226-4485
 

Case Report


First report of Cerebellar Abiotrophy in an Arabian Foal from Argentina.

Sebastian Andres Sadaba, Gonzalo Julian Madariaga, Claudia Malena Corbi Botto, Monica Carino, Maria Eugenia Zappa, Silvia Olgin, Pilar Peral Garcia, Adriana Raquel Massone, Silvina Diaz.


Cited By:8

Abstract
Evidence of cerebellar abiotrophy (CA) was found in a six-month-old Arabian filly with signs of incoordination, head tremor, wobbling, loss of balance and falling over, consistent with a cerebellar lesion. Normal hematology profile blood test and cerebrospinal fluid analysis excluded infectious encephalitis, and serological testing for Sarcocystis neurona was negative. The filly was euthanized. Postmortem X-ray radiography of the cervical cephalic region identified not abnormalities, discounting spinal trauma. The histopathological analysis of serial transverse cerebellar sections by electron microscopy revealed morphological characteristics of apoptotic cells with pyknotic nuclei and degenerate mitochondria, cytoplasmic condensation and areas with absence of Purkinje cells, matching with CA histopathological characteristics. The indirect DNA test for CA was positive in the filly, and DNA test confirmed the CA carrier state in the parents and the recessive inheritance of the disease. To our knowledge this is the first report of a CA case in Argentina.

Key words: cerebellar abiotrophy, Arabian horses, DNA, Purkinje cells, apoptosis


 
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How to Cite this Article
Pubmed Style

Sebastian Andres Sadaba, Gonzalo Julian Madariaga, Claudia Malena Corbi Botto, Monica Carino, Maria Eugenia Zappa, Silvia Olgin, Pilar Peral Garcia, Adriana Raquel Massone, Silvina Diaz. First report of Cerebellar Abiotrophy in an Arabian Foal from Argentina.. Open Vet J. 2016; 6(3): 259-262. doi:10.4314/ovj.v6i3.17


Web Style

Sebastian Andres Sadaba, Gonzalo Julian Madariaga, Claudia Malena Corbi Botto, Monica Carino, Maria Eugenia Zappa, Silvia Olgin, Pilar Peral Garcia, Adriana Raquel Massone, Silvina Diaz. First report of Cerebellar Abiotrophy in an Arabian Foal from Argentina.. https://www.openveterinaryjournal.com/?mno=238076 [Access: February 13, 2024]. doi:10.4314/ovj.v6i3.17


AMA (American Medical Association) Style

Sebastian Andres Sadaba, Gonzalo Julian Madariaga, Claudia Malena Corbi Botto, Monica Carino, Maria Eugenia Zappa, Silvia Olgin, Pilar Peral Garcia, Adriana Raquel Massone, Silvina Diaz. First report of Cerebellar Abiotrophy in an Arabian Foal from Argentina.. Open Vet J. 2016; 6(3): 259-262. doi:10.4314/ovj.v6i3.17



Vancouver/ICMJE Style

Sebastian Andres Sadaba, Gonzalo Julian Madariaga, Claudia Malena Corbi Botto, Monica Carino, Maria Eugenia Zappa, Silvia Olgin, Pilar Peral Garcia, Adriana Raquel Massone, Silvina Diaz. First report of Cerebellar Abiotrophy in an Arabian Foal from Argentina.. Open Vet J. (2016), [cited February 13, 2024]; 6(3): 259-262. doi:10.4314/ovj.v6i3.17



Harvard Style

Sebastian Andres Sadaba, Gonzalo Julian Madariaga, Claudia Malena Corbi Botto, Monica Carino, Maria Eugenia Zappa, Silvia Olgin, Pilar Peral Garcia, Adriana Raquel Massone, Silvina Diaz (2016) First report of Cerebellar Abiotrophy in an Arabian Foal from Argentina.. Open Vet J, 6 (3), 259-262. doi:10.4314/ovj.v6i3.17



Turabian Style

Sebastian Andres Sadaba, Gonzalo Julian Madariaga, Claudia Malena Corbi Botto, Monica Carino, Maria Eugenia Zappa, Silvia Olgin, Pilar Peral Garcia, Adriana Raquel Massone, Silvina Diaz. 2016. First report of Cerebellar Abiotrophy in an Arabian Foal from Argentina.. Open Veterinary Journal, 6 (3), 259-262. doi:10.4314/ovj.v6i3.17



Chicago Style

Sebastian Andres Sadaba, Gonzalo Julian Madariaga, Claudia Malena Corbi Botto, Monica Carino, Maria Eugenia Zappa, Silvia Olgin, Pilar Peral Garcia, Adriana Raquel Massone, Silvina Diaz. "First report of Cerebellar Abiotrophy in an Arabian Foal from Argentina.." Open Veterinary Journal 6 (2016), 259-262. doi:10.4314/ovj.v6i3.17



MLA (The Modern Language Association) Style

Sebastian Andres Sadaba, Gonzalo Julian Madariaga, Claudia Malena Corbi Botto, Monica Carino, Maria Eugenia Zappa, Silvia Olgin, Pilar Peral Garcia, Adriana Raquel Massone, Silvina Diaz. "First report of Cerebellar Abiotrophy in an Arabian Foal from Argentina.." Open Veterinary Journal 6.3 (2016), 259-262. Print. doi:10.4314/ovj.v6i3.17



APA (American Psychological Association) Style

Sebastian Andres Sadaba, Gonzalo Julian Madariaga, Claudia Malena Corbi Botto, Monica Carino, Maria Eugenia Zappa, Silvia Olgin, Pilar Peral Garcia, Adriana Raquel Massone, Silvina Diaz (2016) First report of Cerebellar Abiotrophy in an Arabian Foal from Argentina.. Open Veterinary Journal, 6 (3), 259-262. doi:10.4314/ovj.v6i3.17