E-ISSN 2218-6050 | ISSN 2226-4485
 

Original Article


Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade.


Cited By:7

Abstract
The objective of this study was to compare the efficacy of two sources of omega 3 and 6, fish oil (FO) and linseed oil (LO), orally administered, alone or in combination, for treating experimentally induced keratoconjunctivitis sicca (KCS) in rabbits. Twenty-eight New Zealand rabbits were used in this study. Seven animals were allocated to the C group (negative control), and KCS was induced in 21 animals by topically applying 1% atropine sulfate drops for 7 days. Treatment with atropine was maintained throughout the study period (12 weeks). The rabbits were divided into 3 treatment groups containing 7 animals each: FO group, LO group and FLO group (FO and LO). The animals were evaluated using the Schirmer Tear Test I (STT I), Rose Bengal Test (RBT), fluorescein test (FT), tear film break-up time (TBUT), and conjunctival and histopathological analysis. There was a significant increase in STT I and TBUT values in treatment groups, but the increase occurred earlier in the FO group. The results of the RBT and FT were similar among treatment groups, except FT, in the FLO group, negative staining was only in 12 weeks. There was a significant decrease in the number of goblet cells in the FLO group compared with the other groups. The results demonstrated that orally administered of FO and LO improved the clinical signs of KCS. However, improvement occurred earlier in the FO group. Using oils in combination did not provide additional benefits. These results contribute to the future development of new oral formulations as adjuvant therapies for KCS.

Key words: Fish oil, Keratoconjunctivitis sicca, Linseed oil, Oral, Rabbits


 
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How to Cite this Article
Pubmed Style

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade. Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits. Open Vet J. 2017; 7(3): 277-285. doi:10.4314/ovj.v7i3.13


Web Style

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade. Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits. https://www.openveterinaryjournal.com/?mno=264517 [Access: February 28, 2024]. doi:10.4314/ovj.v7i3.13


AMA (American Medical Association) Style

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade. Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits. Open Vet J. 2017; 7(3): 277-285. doi:10.4314/ovj.v7i3.13



Vancouver/ICMJE Style

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade. Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits. Open Vet J. (2017), [cited February 28, 2024]; 7(3): 277-285. doi:10.4314/ovj.v7i3.13



Harvard Style

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade (2017) Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits. Open Vet J, 7 (3), 277-285. doi:10.4314/ovj.v7i3.13



Turabian Style

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade. 2017. Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits. Open Veterinary Journal, 7 (3), 277-285. doi:10.4314/ovj.v7i3.13



Chicago Style

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade. "Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits." Open Veterinary Journal 7 (2017), 277-285. doi:10.4314/ovj.v7i3.13



MLA (The Modern Language Association) Style

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade. "Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits." Open Veterinary Journal 7.3 (2017), 277-285. Print. doi:10.4314/ovj.v7i3.13



APA (American Psychological Association) Style

Danielle Alves Silva, Gisele Alborgetti Nai, Rogério Giuffrida, Rafael Cabral Barbero, Jacqueline Marcussi Pereira Kuhn, Andressa Carolina da Silva, Ricardo Henrique Zakir Pereira, Maria Fernanda Abbade, Luis Felipe da Costa Zulim, Carolina Silva Guimarães, Silvia Franco Andrade (2017) Comparison between fish and linseed oils administered orally for the treatment of experimentally induced keratoconjunctivitis sicca in rabbits. Open Veterinary Journal, 7 (3), 277-285. doi:10.4314/ovj.v7i3.13