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Case Report


A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern

Floriana Gernone, Mario Ricciardi.


Cited By:1

Abstract
Thiamine is a water-soluble vitamin, which participates in several vital metabolic pathways involved in energy metabolism and neurotransmitter synthesis of mammals. In companion animals thiamine deficiency is classically associated with signs of diffuse encephalopathy and lesions on brainstem nuclei and mesencephalic colliculi evident on magnetic resonance imaging. This paper describes a novel clinical presentation in a thiamine-deficient dog showing multifocal, central and peripheral nervous and cardiovascular system alterations. Brain MRI showed bilateral caudate nuclei damage, with necrotic-malacic evolution, similar to the atypical MRI pattern found in Wernicke’s encephalopathy in humans. Detection of bilateral symmetrical lesions of the caudate nuclei in dogs should prompt consideration of a thiamine deficiency among the differential diagnoses.

Key words: Key words: thiamine deficiency, dog, Wernicke’s encephalopathy, MRI, caudate nuclei.


 
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Pubmed Style

Floriana Gernone, Mario Ricciardi. A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern. Open Vet J. 2017; 7(4): 313-318. doi:10.4314/ovj.v7i4.4


Web Style

Floriana Gernone, Mario Ricciardi. A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern. https://www.openveterinaryjournal.com/?mno=270289 [Access: February 29, 2024]. doi:10.4314/ovj.v7i4.4


AMA (American Medical Association) Style

Floriana Gernone, Mario Ricciardi. A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern. Open Vet J. 2017; 7(4): 313-318. doi:10.4314/ovj.v7i4.4



Vancouver/ICMJE Style

Floriana Gernone, Mario Ricciardi. A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern. Open Vet J. (2017), [cited February 29, 2024]; 7(4): 313-318. doi:10.4314/ovj.v7i4.4



Harvard Style

Floriana Gernone, Mario Ricciardi (2017) A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern. Open Vet J, 7 (4), 313-318. doi:10.4314/ovj.v7i4.4



Turabian Style

Floriana Gernone, Mario Ricciardi. 2017. A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern. Open Veterinary Journal, 7 (4), 313-318. doi:10.4314/ovj.v7i4.4



Chicago Style

Floriana Gernone, Mario Ricciardi. "A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern." Open Veterinary Journal 7 (2017), 313-318. doi:10.4314/ovj.v7i4.4



MLA (The Modern Language Association) Style

Floriana Gernone, Mario Ricciardi. "A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern." Open Veterinary Journal 7.4 (2017), 313-318. Print. doi:10.4314/ovj.v7i4.4



APA (American Psychological Association) Style

Floriana Gernone, Mario Ricciardi (2017) A novel encephalopathy in a thiamine-deficient dog resembling human Wernicke’s disease with atypical MRI pattern. Open Veterinary Journal, 7 (4), 313-318. doi:10.4314/ovj.v7i4.4