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2026, Vol: 16, Issue: 4
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Case Report


Successful management of recurrent feline hepatic lipidosis with equine placenta extract supplementation: A case report

Makoto Akiyoshi, Masaharu Hisasue.


Abstract
Background:
Hepatic lipidosis (HL) is a common and life-threatening hepatopathy in cats, for which novel therapeutic options remain limited.

Case Description:
A 14-year-old neutered male Egyptian Mau cat presented with a one-week history of anorexia, intermittent vomiting, and jaundice. Plasma biochemistry revealed markedly elevated levels of alanine aminotransferase (ALT: 7270 U/L), aspartate aminotransferase (AST: 2754 U/L), and total bilirubin (5.5 mg/dL). Histopathological examination revealed multifocal hepatocellular vacuolar degeneration and random hepatocellular necrosis, consistent with HL, potentially associated with chronic enteropathy and a suspected early neoplastic lymphoid process. Standard therapy with hepatoprotective agents and nutritional support led to limited improvement; therefore, 2 mL of equine placental extract (EPE; Japan Bio Products Co., Ltd., Japan) was administered orally once daily. The cat remained clinically stable with continued administration of EPE and ursodeoxycholic acid.

Conclusion:
EPE may represent a potential novel adjunctive therapy for feline hepatic lipidosis and was temporally associated with biochemical improvement indicating hepatocellular recovery and appetite restoration in this case.

Key words: Cholangitis; Hepatocellular necrosis; Hepatocellular vacuolar degeneration; Lymphoplasmacytic enteritis; Small cell lymphoma.


 
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Pubmed Style

Akiyoshi M, Hisasue M. Successful management of recurrent feline hepatic lipidosis with equine placenta extract supplementation: A case report. Open Vet. J.. 2026; 16(4): 2385-2391. doi:10.5455/OVJ.2026.v16.i4.40

Web Style

Akiyoshi M, Hisasue M. Successful management of recurrent feline hepatic lipidosis with equine placenta extract supplementation: A case report. https://www.openveterinaryjournal.com/?mno=297470 [Access: May 02, 2026]. doi:10.5455/OVJ.2026.v16.i4.40

AMA (American Medical Association) Style

Akiyoshi M, Hisasue M. Successful management of recurrent feline hepatic lipidosis with equine placenta extract supplementation: A case report. Open Vet. J.. 2026; 16(4): 2385-2391. doi:10.5455/OVJ.2026.v16.i4.40


Vancouver/ICMJE Style

Akiyoshi M, Hisasue M. Successful management of recurrent feline hepatic lipidosis with equine placenta extract supplementation: A case report. Open Vet. J.. (2026), [cited May 02, 2026]; 16(4): 2385-2391. doi:10.5455/OVJ.2026.v16.i4.40


Harvard Style

Akiyoshi, M. & Hisasue, . M. (2026) Successful management of recurrent feline hepatic lipidosis with equine placenta extract supplementation: A case report. Open Vet. J., 16 (4), 2385-2391. doi:10.5455/OVJ.2026.v16.i4.40


Turabian Style

Akiyoshi, Makoto, and Masaharu Hisasue. 2026. Successful management of recurrent feline hepatic lipidosis with equine placenta extract supplementation: A case report. Open Veterinary Journal, 16 (4), 2385-2391. doi:10.5455/OVJ.2026.v16.i4.40


Chicago Style

Akiyoshi, Makoto, and Masaharu Hisasue. "Successful management of recurrent feline hepatic lipidosis with equine placenta extract supplementation: A case report." Open Veterinary Journal 16 (2026), 2385-2391. doi:10.5455/OVJ.2026.v16.i4.40


MLA (The Modern Language Association) Style

Akiyoshi, Makoto, and Masaharu Hisasue. "Successful management of recurrent feline hepatic lipidosis with equine placenta extract supplementation: A case report." Open Veterinary Journal 16.4 (2026), 2385-2391. Print. doi:10.5455/OVJ.2026.v16.i4.40


APA (American Psychological Association) Style

Akiyoshi, M. & Hisasue, . M. (2026) Successful management of recurrent feline hepatic lipidosis with equine placenta extract supplementation: A case report. Open Veterinary Journal, 16 (4), 2385-2391. doi:10.5455/OVJ.2026.v16.i4.40


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