E-ISSN 2218-6050 | ISSN 2226-4485
 

Original Article


Evaluation of transforming growth factor beta 1 in dogs with osteoarthritis

Stephan Neumann, Sarah Lauenstein.

Cited by (1)

Abstract
Osteoarthritis is a common problem in daily veterinary practice with insuffient knowledge about disease mechanism. Because fibrosis is a part of the alteration in the effected joints, we investigated the Transforming Growth Factor Beta 1 (TGF-β1) as an important regulation molecule of tissue fibrosis. We chose Osteoarthritis following a cruciate ligament rupture (CLR) because it is a common model of osteoarthritis.
A total of 13 healthy dogs and 38 dogs suffering from CLR were included in this prospective study. The concentration of TGF-β1 was measured in synovial fluid using the “Quantikine Human TGF-β1 Immunoassay“ (Fa. R & D Systems, Minneapolis, USA). There was a significant difference in the TGF-β1 concentration of the synovial fluid of healthy compared to affected patients (p < 0.001). The synovial TGF-β1 concentration also correlated significantly (p = 0.0147) with the synovial viscosity of the affected patients. No significant correlations could be observed to duration of disease, severity of lameness and degree of joint swelling, but also to joint capsule sickness, osteophyte development and degeneration of joint cartilage.
The results of our study show an increased TGF-β1 concentration in knees affected with osteoarthritis as consequence of CLR. So we can conclude that TGF-β1 takes part at the osteoarthritic remodelling process, but different phases of the remodelling process cannot be distinguished by the measurement of TGF-β1.

Key words: dog, osteoarthritis, TGF-β1


 
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How to Cite this Article
Pubmed Style

Stephan Neumann, Sarah Lauenstein. Evaluation of transforming growth factor beta 1 in dogs with osteoarthritis. Open Vet J. 2018; 8(4): 386-392. doi:10.4314/ovj.v8i4.6


Web Style

Stephan Neumann, Sarah Lauenstein. Evaluation of transforming growth factor beta 1 in dogs with osteoarthritis. https://www.openveterinaryjournal.com/?mno=298516 [Access: February 06, 2023]. doi:10.4314/ovj.v8i4.6


AMA (American Medical Association) Style

Stephan Neumann, Sarah Lauenstein. Evaluation of transforming growth factor beta 1 in dogs with osteoarthritis. Open Vet J. 2018; 8(4): 386-392. doi:10.4314/ovj.v8i4.6



Vancouver/ICMJE Style

Stephan Neumann, Sarah Lauenstein. Evaluation of transforming growth factor beta 1 in dogs with osteoarthritis. Open Vet J. (2018), [cited February 06, 2023]; 8(4): 386-392. doi:10.4314/ovj.v8i4.6



Harvard Style

Stephan Neumann, Sarah Lauenstein (2018) Evaluation of transforming growth factor beta 1 in dogs with osteoarthritis. Open Vet J, 8 (4), 386-392. doi:10.4314/ovj.v8i4.6



Turabian Style

Stephan Neumann, Sarah Lauenstein. 2018. Evaluation of transforming growth factor beta 1 in dogs with osteoarthritis. Open Veterinary Journal, 8 (4), 386-392. doi:10.4314/ovj.v8i4.6



Chicago Style

Stephan Neumann, Sarah Lauenstein. "Evaluation of transforming growth factor beta 1 in dogs with osteoarthritis." Open Veterinary Journal 8 (2018), 386-392. doi:10.4314/ovj.v8i4.6



MLA (The Modern Language Association) Style

Stephan Neumann, Sarah Lauenstein. "Evaluation of transforming growth factor beta 1 in dogs with osteoarthritis." Open Veterinary Journal 8.4 (2018), 386-392. Print. doi:10.4314/ovj.v8i4.6



APA (American Psychological Association) Style

Stephan Neumann, Sarah Lauenstein (2018) Evaluation of transforming growth factor beta 1 in dogs with osteoarthritis. Open Veterinary Journal, 8 (4), 386-392. doi:10.4314/ovj.v8i4.6