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Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana)

M.M. Hassan1,*, A.K. Saha1, S.A. Khan1, A. Islam1, M. Mahabub-Uz-Zaman2 and S.S.U. Ahmed3.


Cited By:44

Abstract
This study screened the antidiarrhoeal, antimicrobial and cytotoxic effects of ethanol-extracted leaves of yellow oleander (Thevetia peruviana). The extract was tested against castor oil-induced diarrhoea in a model of albino rats and showed significant antidiarrhoeal activity (P<0.01). Disc diffusion technique was used to test the in vitro antibacterial activities of the extract and exhibited poor antibacterial activities against both Gram positive and Gram negative bacteria (mainly Bacillus sp). Ethanol-extracted leaves of yellow oleander showed narrow zone of inhibition in the bacterial lawns of Shigella flexineri, Salmonella typhi, Klebsiella sp, Staphylococcus aureus and Shigella sonnei. Cytotoxicty was determined against brine shrimp nauplii and LC50 of the plant extract was determined as 627.21�g/ml. The wide range of LC50 value denotes the safety effect of the extract.

Key words: Antidiarrhoeal, Antimicrobial, Cytotoxicity, Albino rats, Brine shrimp, Yellow oleander, LC50


 
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How to Cite this Article
Pubmed Style

M.M. Hassan,, A.K. Saha, S.A. Khan, A. Islam, M. Mahabub-Uz-Zaman and S.S.U. Ahmed. Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana). Open Vet J. 2011; 1(0): 28-31. doi:10.5455/OVJ.2011.v1.i0.p28


Web Style

M.M. Hassan,, A.K. Saha, S.A. Khan, A. Islam, M. Mahabub-Uz-Zaman and S.S.U. Ahmed. Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana). https://www.openveterinaryjournal.com/?mno=302656804 [Access: February 13, 2024]. doi:10.5455/OVJ.2011.v1.i0.p28


AMA (American Medical Association) Style

M.M. Hassan,, A.K. Saha, S.A. Khan, A. Islam, M. Mahabub-Uz-Zaman and S.S.U. Ahmed. Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana). Open Vet J. 2011; 1(0): 28-31. doi:10.5455/OVJ.2011.v1.i0.p28



Vancouver/ICMJE Style

M.M. Hassan,, A.K. Saha, S.A. Khan, A. Islam, M. Mahabub-Uz-Zaman and S.S.U. Ahmed. Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana). Open Vet J. (2011), [cited February 13, 2024]; 1(0): 28-31. doi:10.5455/OVJ.2011.v1.i0.p28



Harvard Style

M.M. Hassan,, A.K. Saha, S.A. Khan, A. Islam, M. Mahabub-Uz-Zaman and S.S.U. Ahmed (2011) Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana). Open Vet J, 1 (0), 28-31. doi:10.5455/OVJ.2011.v1.i0.p28



Turabian Style

M.M. Hassan,, A.K. Saha, S.A. Khan, A. Islam, M. Mahabub-Uz-Zaman and S.S.U. Ahmed. 2011. Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana). Open Veterinary Journal, 1 (0), 28-31. doi:10.5455/OVJ.2011.v1.i0.p28



Chicago Style

M.M. Hassan,, A.K. Saha, S.A. Khan, A. Islam, M. Mahabub-Uz-Zaman and S.S.U. Ahmed. "Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana)." Open Veterinary Journal 1 (2011), 28-31. doi:10.5455/OVJ.2011.v1.i0.p28



MLA (The Modern Language Association) Style

M.M. Hassan,, A.K. Saha, S.A. Khan, A. Islam, M. Mahabub-Uz-Zaman and S.S.U. Ahmed. "Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana)." Open Veterinary Journal 1.0 (2011), 28-31. Print. doi:10.5455/OVJ.2011.v1.i0.p28



APA (American Psychological Association) Style

M.M. Hassan,, A.K. Saha, S.A. Khan, A. Islam, M. Mahabub-Uz-Zaman and S.S.U. Ahmed (2011) Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana). Open Veterinary Journal, 1 (0), 28-31. doi:10.5455/OVJ.2011.v1.i0.p28