TGF-β1 serum concentrations and receptor expressions in the lens capsular of dogs with diabetes mellitus

Stephan Neumann1; *; Jens Linek2; Gerhard Loesenbeck3; Julia Schüttler1 and Sonja Gaedke1

doi:10.4314/ovj.v7i1.2

2023, Vol: 13, Issue: 1

13/1Current Issue Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

OVJ Manuscript Submission Form

« Previous Article

Open Vet J. 2017; 7(1): 12-15

doi: 10.4314/ovj.v7i1.2

TGF-β1 serum concentrations and receptor expressions in the lens capsular of dogs with diabetes mellitus

Stephan Neumann1,*, Jens Linek2, Gerhard Loesenbeck3, Julia Schüttler1 and Sonja Gaedke1.

Cited by (3)

Abstract
Tissue fibrosis as complication of diabetes mellitus is known in humans. Because TGF-β1induces fibrosis and is
elevated in humans suffering from diabetes mellitus we measured this growth factor in serum of dogs with diabetes
mellitus and compared it with healthy dogs and those with fibrotic diseases. Further we measured the expression of
TGF-β1receptor on lens capsule to investigate possible association between diabetes mellitus and cataract associated
alterations. TGF-β1 was measured in serum of 12 dogs with diabetes mellitus, 20 healthy controls and 12 dogs with
fibrotic diseases. Dogs with diabetes mellitus and fibrotic diseases have significantly increased TGF-β1 serum
concentrations compared to healthy controls. Some dogs with diabetes mellitus showed increased expression of TGF-
β1 receptor in lens capsule. Based on our observations we can conclude that TGF-β1 elevation in dogs with diabetes
mellitus may induces complications of the disease and may participates on lens alteration.

Key words: Cataracts, Diabetes mellitus, Dogs, TGF-β1.

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Stephan Neumann1 Articles by * Articles by Jens Linek2 Articles by Gerhard Loesenbeck3 Articles by Julia Schüttler1 and Sonja Gaedke1
	on Google
	on Google Scholar

This Article Cited By the following articles

Status of higher TGF-β1 and TGF-β2 levels in the aqueous humour of patients with diabetes and cataracts BMC Ophthalmol 2022; 22(1): .	1

Exosomal miRNA Analysis of Aqueous Humour of Diabetes and Cataract Patients Current Eye Research 2021; 46(3): 324.	2

Salvia miltiorrhiza in diabetes: A review of its pharmacology, phytochemistry, and safety Phytomedicine 2019; 58(): 152871.	3

How to Cite this Article

Pubmed Style

Stephan Neumann,, Jens Linek, Gerhard Loesenbeck, Julia Schuttler and Sonja Gaedke. TGF-β1 serum concentrations and receptor expressions in the lens capsular of dogs with diabetes mellitus. Open Vet J. 2017; 7(1): 12-15. doi:10.4314/ovj.v7i1.2

Web Style

Stephan Neumann,, Jens Linek, Gerhard Loesenbeck, Julia Schuttler and Sonja Gaedke. TGF-β1 serum concentrations and receptor expressions in the lens capsular of dogs with diabetes mellitus. https://www.openveterinaryjournal.com/?mno=302656883 [Access: February 06, 2023]. doi:10.4314/ovj.v7i1.2

AMA (American Medical Association) Style

Stephan Neumann,, Jens Linek, Gerhard Loesenbeck, Julia Schuttler and Sonja Gaedke. TGF-β1 serum concentrations and receptor expressions in the lens capsular of dogs with diabetes mellitus. Open Vet J. 2017; 7(1): 12-15. doi:10.4314/ovj.v7i1.2

Vancouver/ICMJE Style

Stephan Neumann,, Jens Linek, Gerhard Loesenbeck, Julia Schuttler and Sonja Gaedke. TGF-β1 serum concentrations and receptor expressions in the lens capsular of dogs with diabetes mellitus. Open Vet J. (2017), [cited February 06, 2023]; 7(1): 12-15. doi:10.4314/ovj.v7i1.2

Harvard Style

Stephan Neumann,, Jens Linek, Gerhard Loesenbeck, Julia Schuttler and Sonja Gaedke (2017) TGF-β1 serum concentrations and receptor expressions in the lens capsular of dogs with diabetes mellitus. Open Vet J, 7 (1), 12-15. doi:10.4314/ovj.v7i1.2

Turabian Style

Stephan Neumann,, Jens Linek, Gerhard Loesenbeck, Julia Schuttler and Sonja Gaedke. 2017. TGF-β1 serum concentrations and receptor expressions in the lens capsular of dogs with diabetes mellitus. Open Veterinary Journal, 7 (1), 12-15. doi:10.4314/ovj.v7i1.2

Chicago Style

Stephan Neumann,, Jens Linek, Gerhard Loesenbeck, Julia Schuttler and Sonja Gaedke. "TGF-β1 serum concentrations and receptor expressions in the lens capsular of dogs with diabetes mellitus." Open Veterinary Journal 7 (2017), 12-15. doi:10.4314/ovj.v7i1.2

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Author Login Reviewer Login About Publisher Publication Ethics and Publication Malpractice Statement Conflict of Interest Policy Plagiarism Policy Terms of Use License Information

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access. The articles in Open Veterinary Journal are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

Copyright � 2023 Open Veterinary Journal All Rights Reserved. Subject to change without notice from or liability to Open Veterinary Journal. For best results, please use Internet Explorer or Google Chrome	Contact Information All correspondence should be addressed to: *Prof. Ibrahim Eldaghayes: Owner, Founder and Editor-in-Chief* Open Veterinary Journal Faculty of Veterinary Medicine University of Tripoli P.O. Box 13662, Tripoli, Libya Email: ibrahim.eldaghayes@vetmed.edu.ly

Contact Information

How to cite this article