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Case Report


Effective treatment with mitotane for a canine case of Ectopic Cushing's syndrome-related pheochromocytoma.

Konatsu Miura, Hiroshi Sunahara, Yusuke Sakai.


Cited By:1

Abstract
In humans, ectopic Cushing’s syndrome (ECS) is characterized by hypercortisolemia, which
is caused by small lung carcinoma, bronchial carcinoids, and pheochromocytoma. In dogs, only a few cases of ECS associated with pheochromocytoma has been reported to date. Herein, we describe a canine case of malignant pheochromocytoma that presumed to be the cause of ECS. An 11-year-old, castrated, male Toy Poodle with hypercortisolemia was diagnosed as adrenal tumor and treated with mitotane. Although repeated adrenocorticotropic hormone stimulation tests revealed improvement of the dog’s condition by mitotane treatment, its condition started declining from 197 days post-diagnosis, and he died on day 280. The
necropsy revealed the adrenal tumor was pheochromocytoma, not adrenocortical tumor. However, because of no pathological change in pituitary gland and the other adrenal gland, the pheochromocytoma was presumed to be the cause of ECS. This is the first report that describe the effectiveness of mitotane against presumed ECS-related pheochromocytoma.

Key words: dog, ectopic Cushing’s syndrome, hypercortisolemia, pheochromocytoma.


 
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How to Cite this Article
Pubmed Style

Miura K, Sunahara H, Sakai Y. Effective treatment with mitotane for a canine case of Ectopic Cushing's syndrome-related pheochromocytoma.. Open Vet J. 2022; 12(5): 762-767. doi:10.5455/OVJ.2022.v12.i5.22

Web Style

Miura K, Sunahara H, Sakai Y. Effective treatment with mitotane for a canine case of Ectopic Cushing's syndrome-related pheochromocytoma.. https://www.openveterinaryjournal.com/?mno=54130 [Access: April 24, 2025]. doi:10.5455/OVJ.2022.v12.i5.22

AMA (American Medical Association) Style

Miura K, Sunahara H, Sakai Y. Effective treatment with mitotane for a canine case of Ectopic Cushing's syndrome-related pheochromocytoma.. Open Vet J. 2022; 12(5): 762-767. doi:10.5455/OVJ.2022.v12.i5.22


Vancouver/ICMJE Style

Miura K, Sunahara H, Sakai Y. Effective treatment with mitotane for a canine case of Ectopic Cushing's syndrome-related pheochromocytoma.. Open Vet J. (2022), [cited April 24, 2025]; 12(5): 762-767. doi:10.5455/OVJ.2022.v12.i5.22


Harvard Style

Miura, K., Sunahara, . H. & Sakai, . Y. (2022) Effective treatment with mitotane for a canine case of Ectopic Cushing's syndrome-related pheochromocytoma.. Open Vet J, 12 (5), 762-767. doi:10.5455/OVJ.2022.v12.i5.22


Turabian Style

Miura, Konatsu, Hiroshi Sunahara, and Yusuke Sakai. 2022. Effective treatment with mitotane for a canine case of Ectopic Cushing's syndrome-related pheochromocytoma.. Open Veterinary Journal, 12 (5), 762-767. doi:10.5455/OVJ.2022.v12.i5.22


Chicago Style

Miura, Konatsu, Hiroshi Sunahara, and Yusuke Sakai. "Effective treatment with mitotane for a canine case of Ectopic Cushing's syndrome-related pheochromocytoma.." Open Veterinary Journal 12 (2022), 762-767. doi:10.5455/OVJ.2022.v12.i5.22


MLA (The Modern Language Association) Style

Miura, Konatsu, Hiroshi Sunahara, and Yusuke Sakai. "Effective treatment with mitotane for a canine case of Ectopic Cushing's syndrome-related pheochromocytoma.." Open Veterinary Journal 12.5 (2022), 762-767. Print. doi:10.5455/OVJ.2022.v12.i5.22


APA (American Psychological Association) Style

Miura, K., Sunahara, . H. & Sakai, . Y. (2022) Effective treatment with mitotane for a canine case of Ectopic Cushing's syndrome-related pheochromocytoma.. Open Veterinary Journal, 12 (5), 762-767. doi:10.5455/OVJ.2022.v12.i5.22


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