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2025, Vol: 15, Issue: 3
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Original Article


Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research

Achmad Firdaus Sani, Widjiati Widjiati, Paulus Sugianto, Muhammad Hamdan, Jovian Philip Swatan.


Cited By:1

Abstract
Background: Asymptomatic carotid artery stenosis has become more prevalent worldwide and is often associated with a poor prognosis. Numerous guidelines highlighted surgical interventions as treatment for carotid artery stenosis, but only a few recommendations were made regarding non-surgical interventions due to its limited data.
Aims: This study aims to develop a mice model for research in non-surgical interventions of asymptomatic carotid artery stenosis.
Methods: Adult male Rattus Norvegicus, Wistar strain models with bilateral asymptomatic common carotid artery stenosis (BACAS) were created by ligating the common carotid artery with a 0.6 mm diameter needle and then removing the needle. The mice’s body weight, clinical signs and symptoms, and post-mortem brain analysis were compared between the sham-operated group and the BACAS group. Results: The mortality rate among BACAS group is 11.11%. There is no significant difference in mean body weight before surgery, after the observation period, and percentage of weight decrease between sham-operated and BACAS groups (p=0.710, 0.632, and 0.806, respectively). None of the surviving mice in this study exhibit signs of motor paralysis. Gross examination of the brain reveals no signs of infarction or hemorrhage.
Conclusion: We have established a novel BACAS mouse model which is cost-efficient, easy to produce, and with no significant alteration in body weight, clinical parameters, and brain morphology.

Key words: Animal models of disease, carotid arteries, mouse models, non-communicable disease, Scientific research


 
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How to Cite this Article
Pubmed Style

Sani AF, Widjiati W, Sugianto P, Hamdan M, Swatan JP. Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research. Open Vet J. 2022; 12(4): 463-468. doi:10.5455/OVJ.2022.v12.i4.7

Web Style

Sani AF, Widjiati W, Sugianto P, Hamdan M, Swatan JP. Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research. https://www.openveterinaryjournal.com/?mno=5523 [Access: April 24, 2025]. doi:10.5455/OVJ.2022.v12.i4.7

AMA (American Medical Association) Style

Sani AF, Widjiati W, Sugianto P, Hamdan M, Swatan JP. Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research. Open Vet J. 2022; 12(4): 463-468. doi:10.5455/OVJ.2022.v12.i4.7


Vancouver/ICMJE Style

Sani AF, Widjiati W, Sugianto P, Hamdan M, Swatan JP. Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research. Open Vet J. (2022), [cited April 24, 2025]; 12(4): 463-468. doi:10.5455/OVJ.2022.v12.i4.7


Harvard Style

Sani, A. F., Widjiati, . W., Sugianto, . P., Hamdan, . M. & Swatan, . J. P. (2022) Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research. Open Vet J, 12 (4), 463-468. doi:10.5455/OVJ.2022.v12.i4.7


Turabian Style

Sani, Achmad Firdaus, Widjiati Widjiati, Paulus Sugianto, Muhammad Hamdan, and Jovian Philip Swatan. 2022. Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research. Open Veterinary Journal, 12 (4), 463-468. doi:10.5455/OVJ.2022.v12.i4.7


Chicago Style

Sani, Achmad Firdaus, Widjiati Widjiati, Paulus Sugianto, Muhammad Hamdan, and Jovian Philip Swatan. "Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research." Open Veterinary Journal 12 (2022), 463-468. doi:10.5455/OVJ.2022.v12.i4.7


MLA (The Modern Language Association) Style

Sani, Achmad Firdaus, Widjiati Widjiati, Paulus Sugianto, Muhammad Hamdan, and Jovian Philip Swatan. "Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research." Open Veterinary Journal 12.4 (2022), 463-468. Print. doi:10.5455/OVJ.2022.v12.i4.7


APA (American Psychological Association) Style

Sani, A. F., Widjiati, . W., Sugianto, . P., Hamdan, . M. & Swatan, . J. P. (2022) Bilateral Asymptomatic Common Carotid Artery Stenosis (BACAS) Mouse Model for Stroke Research. Open Veterinary Journal, 12 (4), 463-468. doi:10.5455/OVJ.2022.v12.i4.7


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