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Original Article


Effect of ethanol extract from Chrysanthemum cinerariiforium leaves on Ki-67 proliferation and dysplasia severity in a rat model of oral squamous cell carcinoma

Anik Listiyana, Risma Aprinda Kristanti, Al Mazida Fauzil rumondang, Anggun Putri Maulana Ahmad, Lina Fitria Astari, Christyaji Indradmojo, Fidia Rizkiah Inayatilah.


Cited By:2

Abstract
Background:
Oral Squamous Cell Carcinoma (OSCC) is a malignant tumor that can rapidly infiltrate the oral epithelial tissue and cause high mortality worldwide because the available therapies are less effective. Chrysanthemum cinerariifolium leaf contains secondary metabolites as anti-inflammatory, antioxidant, anticancer, and antimutagenic.
Aims:
The study aimed to analyze the ethanolic extract of C. cinerariifolium leaf in reducing proliferation (Ki-67) and the degree of dysplasia in OSCC rats.
Methods:
This study used male Sprague Dawley induced by DMBA 0.5% and divided into five treatment groups, namely positive control/C+ (sick), negative control/C- (healthy), and treatment group generated with DMBA and given extract C. cinerariifolium leaf with successive doses of T1, T2, and T3 (50, 100 and 200 mg/k g bw). The oral epithelium was stained with hematoxylin and eosin and immunohistochemically stained with a Ki-67 monoclonal antibody. Statistical analysis utilizing One-Way ANOVA.
Results:
The results showed that T1 at a dose of 200 mg/kg bw could significantly reduce Ki-67 expression and the degree of oral epithelial dysplasia (p<0.05) close to healthy controls.
Conclusion:
The conclusion shows that C. cinerariifolium leaf extract can be a therapy against OSCC by decreasing cell proliferation and the degree of oral epithelial dysplasia.

Key words: Carcinoma, C. cinerariifolium, Inflammation, Proliferation, DMBA


 
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How to Cite this Article
Pubmed Style

Listiyana A, Kristanti RA, rumondang AMF, Ahmad APM, Astari LF, Indradmojo C, Inayatilah FR. Effect of ethanol extract from Chrysanthemum cinerariiforium leaves on Ki-67 proliferation and dysplasia severity in a rat model of oral squamous cell carcinoma. Open Vet J. 2023; 13(1): 99-107. doi:10.5455/OVJ.2023.v13.i1.10

Web Style

Listiyana A, Kristanti RA, rumondang AMF, Ahmad APM, Astari LF, Indradmojo C, Inayatilah FR. Effect of ethanol extract from Chrysanthemum cinerariiforium leaves on Ki-67 proliferation and dysplasia severity in a rat model of oral squamous cell carcinoma. https://www.openveterinaryjournal.com/?mno=128054 [Access: December 03, 2024]. doi:10.5455/OVJ.2023.v13.i1.10

AMA (American Medical Association) Style

Listiyana A, Kristanti RA, rumondang AMF, Ahmad APM, Astari LF, Indradmojo C, Inayatilah FR. Effect of ethanol extract from Chrysanthemum cinerariiforium leaves on Ki-67 proliferation and dysplasia severity in a rat model of oral squamous cell carcinoma. Open Vet J. 2023; 13(1): 99-107. doi:10.5455/OVJ.2023.v13.i1.10


Vancouver/ICMJE Style

Listiyana A, Kristanti RA, rumondang AMF, Ahmad APM, Astari LF, Indradmojo C, Inayatilah FR. Effect of ethanol extract from Chrysanthemum cinerariiforium leaves on Ki-67 proliferation and dysplasia severity in a rat model of oral squamous cell carcinoma. Open Vet J. (2023), [cited December 03, 2024]; 13(1): 99-107. doi:10.5455/OVJ.2023.v13.i1.10


Harvard Style

Listiyana, A., Kristanti, . R. A., rumondang, . A. M. F., Ahmad, . A. P. M., Astari, . L. F., Indradmojo, . C. & Inayatilah, . F. R. (2023) Effect of ethanol extract from Chrysanthemum cinerariiforium leaves on Ki-67 proliferation and dysplasia severity in a rat model of oral squamous cell carcinoma. Open Vet J, 13 (1), 99-107. doi:10.5455/OVJ.2023.v13.i1.10


Turabian Style

Listiyana, Anik, Risma Aprinda Kristanti, Al Mazida Fauzil rumondang, Anggun Putri Maulana Ahmad, Lina Fitria Astari, Christyaji Indradmojo, and Fidia Rizkiah Inayatilah. 2023. Effect of ethanol extract from Chrysanthemum cinerariiforium leaves on Ki-67 proliferation and dysplasia severity in a rat model of oral squamous cell carcinoma. Open Veterinary Journal, 13 (1), 99-107. doi:10.5455/OVJ.2023.v13.i1.10


Chicago Style

Listiyana, Anik, Risma Aprinda Kristanti, Al Mazida Fauzil rumondang, Anggun Putri Maulana Ahmad, Lina Fitria Astari, Christyaji Indradmojo, and Fidia Rizkiah Inayatilah. "Effect of ethanol extract from Chrysanthemum cinerariiforium leaves on Ki-67 proliferation and dysplasia severity in a rat model of oral squamous cell carcinoma." Open Veterinary Journal 13 (2023), 99-107. doi:10.5455/OVJ.2023.v13.i1.10


MLA (The Modern Language Association) Style

Listiyana, Anik, Risma Aprinda Kristanti, Al Mazida Fauzil rumondang, Anggun Putri Maulana Ahmad, Lina Fitria Astari, Christyaji Indradmojo, and Fidia Rizkiah Inayatilah. "Effect of ethanol extract from Chrysanthemum cinerariiforium leaves on Ki-67 proliferation and dysplasia severity in a rat model of oral squamous cell carcinoma." Open Veterinary Journal 13.1 (2023), 99-107. Print. doi:10.5455/OVJ.2023.v13.i1.10


APA (American Psychological Association) Style

Listiyana, A., Kristanti, . R. A., rumondang, . A. M. F., Ahmad, . A. P. M., Astari, . L. F., Indradmojo, . C. & Inayatilah, . F. R. (2023) Effect of ethanol extract from Chrysanthemum cinerariiforium leaves on Ki-67 proliferation and dysplasia severity in a rat model of oral squamous cell carcinoma. Open Veterinary Journal, 13 (1), 99-107. doi:10.5455/OVJ.2023.v13.i1.10


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