E-ISSN 2218-6050 | ISSN 2226-4485
 
2024, Vol: 14, Issue: 4
14 / 4Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

OVJ Manuscript Submission Form

Case Report


Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib

Masashi Yuki, Hiroto Taira, Momoko Narita, Takanori Inden, Syunya Yokota, Eiji Naito, Sadatoshi Maeda.


Abstract
Background:
Precursor-targeted immune-mediated anemia (PIMA) has been described in dogs presenting with nonregenerative anemia and evidence of ineffective erythropoiesis. Although it has been suggested that its occurrence may be related to the immune targeting of erythroid precursors, this pathogenesis has not been established. PIMA is mainly treated with glucocorticoids, and in cases where glucocorticoids alone are not effective, immunosuppressants are also used as combination therapy. However, not all cases of PIMA go into remission after these treatments.
Case Description:
Two dogs with severe nonregenerative anemia diagnosed as PIMA based on the results of clinical pathological examinations, including bone marrow examination, were treated with whole-blood transfusion and immunosuppressive doses of prednisolone, mycophenolate mofetil, and cyclosporine. However, these treatments failed to achieve remission of PIMA. Therefore, concomitant administration of oclacitinib, which is a Janus kinase-1 inhibitor that has been applied recently to the treatment of immune-mediated diseases, was performed; this combined regimen improved the anemia and achieved complete remission of PIMA.
Conclusion:
Oclacitinib may be an option for the treatment of PIMA in dogs failing to achieve remission with conventional immunosuppressive therapy.

Key words: Cyclosporine, Dog, Oclacitinib, Prednisolone, Precursor-targeted immune-mediated anemia


 
ARTICLE TOOLS
Abstract
PDF Fulltext
HTML Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Masashi Yuki
Articles by Hiroto Taira
Articles by Momoko Narita
Articles by Takanori Inden
Articles by Syunya Yokota
Articles by Eiji Naito
Articles by Sadatoshi Maeda
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

MY, HT, MN, TI, SY, EN, Maeda S. Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib. Open Vet J. 2023; 13(9): 1205-1211. doi:10.5455/OVJ.2023.v13.i9.16

Web Style

MY, HT, MN, TI, SY, EN, Maeda S. Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib. https://www.openveterinaryjournal.com/?mno=153759 [Access: May 02, 2024]. doi:10.5455/OVJ.2023.v13.i9.16

AMA (American Medical Association) Style

MY, HT, MN, TI, SY, EN, Maeda S. Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib. Open Vet J. 2023; 13(9): 1205-1211. doi:10.5455/OVJ.2023.v13.i9.16


Vancouver/ICMJE Style

MY, HT, MN, TI, SY, EN, Maeda S. Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib. Open Vet J. (2023), [cited May 02, 2024]; 13(9): 1205-1211. doi:10.5455/OVJ.2023.v13.i9.16


Harvard Style

, M. Y., , . H. T., , . M. N., , . T. I., , . S. Y., , . E. N. & Maeda, . S. (2023) Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib. Open Vet J, 13 (9), 1205-1211. doi:10.5455/OVJ.2023.v13.i9.16


Turabian Style

, Masashi Yuki, Hiroto Taira, Momoko Narita, Takanori Inden, Syunya Yokota, Eiji Naito, and Sadatoshi Maeda. 2023. Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib. Open Veterinary Journal, 13 (9), 1205-1211. doi:10.5455/OVJ.2023.v13.i9.16


Chicago Style

, Masashi Yuki, Hiroto Taira, Momoko Narita, Takanori Inden, Syunya Yokota, Eiji Naito, and Sadatoshi Maeda. "Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib." Open Veterinary Journal 13 (2023), 1205-1211. doi:10.5455/OVJ.2023.v13.i9.16


MLA (The Modern Language Association) Style

, Masashi Yuki, Hiroto Taira, Momoko Narita, Takanori Inden, Syunya Yokota, Eiji Naito, and Sadatoshi Maeda. "Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib." Open Veterinary Journal 13.9 (2023), 1205-1211. Print. doi:10.5455/OVJ.2023.v13.i9.16


APA (American Psychological Association) Style

, M. Y., , . H. T., , . M. N., , . T. I., , . S. Y., , . E. N. & Maeda, . S. (2023) Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib. Open Veterinary Journal, 13 (9), 1205-1211. doi:10.5455/OVJ.2023.v13.i9.16


Author LoginReviewer LoginAbout PublisherPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyTerms of UseLicense Information

About Open Veterinary Journal

Open Veterinary Journal provides a fast track coupled with high quality peer review process for original research articles, review articles, short communi ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes: Owner, Founder and Editor-in-Chief

Open Veterinary Journal, Faculty of Veterinary Medicine, University of Tripoli

P.O. Box 13662, Tripoli, Libya


Email: ibrahim.eldaghayes@vetmed.edu.ly