E-ISSN 2218-6050 | ISSN 2226-4485
 
2025, Vol: 15, Issue: 2
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Case Report


Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib

Masashi Yuki, Hiroto Taira, Momoko Narita, Takanori Inden, Syunya Yokota, Eiji Naito, Sadatoshi Maeda.


Abstract
Background:
Precursor-targeted immune-mediated anemia (PIMA) has been described in dogs presenting with nonregenerative anemia and evidence of ineffective erythropoiesis. Although it has been suggested that its occurrence may be related to the immune targeting of erythroid precursors, this pathogenesis has not been established. PIMA is mainly treated with glucocorticoids, and in cases where glucocorticoids alone are not effective, immunosuppressants are also used as combination therapy. However, not all cases of PIMA go into remission after these treatments.
Case Description:
Two dogs with severe nonregenerative anemia diagnosed as PIMA based on the results of clinical pathological examinations, including bone marrow examination, were treated with whole-blood transfusion and immunosuppressive doses of prednisolone, mycophenolate mofetil, and cyclosporine. However, these treatments failed to achieve remission of PIMA. Therefore, concomitant administration of oclacitinib, which is a Janus kinase-1 inhibitor that has been applied recently to the treatment of immune-mediated diseases, was performed; this combined regimen improved the anemia and achieved complete remission of PIMA.
Conclusion:
Oclacitinib may be an option for the treatment of PIMA in dogs failing to achieve remission with conventional immunosuppressive therapy.

Key words: Cyclosporine, Dog, Oclacitinib, Prednisolone, Precursor-targeted immune-mediated anemia


 
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How to Cite this Article
Pubmed Style

Yuki M, Taira H, Narita M, Inden T, Yokota S, Naito E, Maeda S. Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib. Open Vet J. 2023; 13(9): 1205-1211. doi:10.5455/OVJ.2023.v13.i9.16

Web Style

Yuki M, Taira H, Narita M, Inden T, Yokota S, Naito E, Maeda S. Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib. https://www.openveterinaryjournal.com/?mno=153759 [Access: March 13, 2025]. doi:10.5455/OVJ.2023.v13.i9.16

AMA (American Medical Association) Style

Yuki M, Taira H, Narita M, Inden T, Yokota S, Naito E, Maeda S. Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib. Open Vet J. 2023; 13(9): 1205-1211. doi:10.5455/OVJ.2023.v13.i9.16


Vancouver/ICMJE Style

Yuki M, Taira H, Narita M, Inden T, Yokota S, Naito E, Maeda S. Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib. Open Vet J. (2023), [cited March 13, 2025]; 13(9): 1205-1211. doi:10.5455/OVJ.2023.v13.i9.16


Harvard Style

Yuki, M., Taira, . H., Narita, . M., Inden, . T., Yokota, . S., Naito, . E. & Maeda, . S. (2023) Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib. Open Vet J, 13 (9), 1205-1211. doi:10.5455/OVJ.2023.v13.i9.16


Turabian Style

Yuki, Masashi, Hiroto Taira, Momoko Narita, Takanori Inden, Syunya Yokota, Eiji Naito, and Sadatoshi Maeda. 2023. Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib. Open Veterinary Journal, 13 (9), 1205-1211. doi:10.5455/OVJ.2023.v13.i9.16


Chicago Style

Yuki, Masashi, Hiroto Taira, Momoko Narita, Takanori Inden, Syunya Yokota, Eiji Naito, and Sadatoshi Maeda. "Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib." Open Veterinary Journal 13 (2023), 1205-1211. doi:10.5455/OVJ.2023.v13.i9.16


MLA (The Modern Language Association) Style

Yuki, Masashi, Hiroto Taira, Momoko Narita, Takanori Inden, Syunya Yokota, Eiji Naito, and Sadatoshi Maeda. "Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib." Open Veterinary Journal 13.9 (2023), 1205-1211. Print. doi:10.5455/OVJ.2023.v13.i9.16


APA (American Psychological Association) Style

Yuki, M., Taira, . H., Narita, . M., Inden, . T., Yokota, . S., Naito, . E. & Maeda, . S. (2023) Complete remission of two canine cases with precursor-targeted immune-mediated anemia after combination therapy with prednisolone, cyclosporine, and oclacitinib. Open Veterinary Journal, 13 (9), 1205-1211. doi:10.5455/OVJ.2023.v13.i9.16


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