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Research Article


Liver histopathological and oxidative stress assessment by a combination of formaldehyde and oxytetracycline in sea bass (Dicentrarchuslabrax L)

Zouhour Ouanes Ben Othmen, Mohamed Ali JERBI, Rim Timoumi, Raouf Besbes, Zohra Haouas, Lotfi Achour, Altayeb Elazomi, Abdurraouf Zaet, Lazhar Zourgui, Adnen Kacem.


Abstract
Background:
Formaldehyde (FA) and oxytetracycline (OTC) arechemicals commonly used in aquaculture to prevent or to treat fish’s diseases due to protozoa, parasites and bacteria.
Aim:
The goal of the present study is to assess liver injury and oxidative stress induced by exposure of sea bass (Dicentrarchuslabrax L) to therapeutic doses of FA (200 mL.m-3) and OTC (40 g.m-3) under same conditions being applied in intensive aquaculture systems in Tunisia.
Methods:
Liver histopathological survey was achieved after 5 and 10 days of exposure to FA, OTC separately or mixed. In parallel, liver catalase activity and malondialdehyde (MDA) were measured to assess oxidative stress.
Results:
Results showed that treatment with FA and OTC used alone or in combinations induced liver damage as measured by sinusoid dilatation, intensive vacuolisation, blood congestion, and focal necrosis. Significant elevation in catalyse activity and MDA levels were also observed in liver homogenates by the treatment (p≤005).
Conclusion:
Combined treatment induced higher effects suggesting the critical hazards associated to FA and OTC when released to the environment.

Key words: Liver histopathology, Oxidative damage, Sea bass, Formaldehyde, Oxytetracycline


 
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How to Cite this Article
Pubmed Style

Othmen ZOB, JERBI MA, Timoumi R, Besbes R, Haouas Z, Achour L, Elazomi A, Zaet A, Zourgui L, Kacem A. Liver histopathological and oxidative stress assessment by a combination of formaldehyde and oxytetracycline in sea bass (Dicentrarchuslabrax L). Open Vet J. 2024; 14(2): 630-639. doi:10.5455/OVJ.2024.v14.i2.3

Web Style

Othmen ZOB, JERBI MA, Timoumi R, Besbes R, Haouas Z, Achour L, Elazomi A, Zaet A, Zourgui L, Kacem A. Liver histopathological and oxidative stress assessment by a combination of formaldehyde and oxytetracycline in sea bass (Dicentrarchuslabrax L). https://www.openveterinaryjournal.com/?mno=165176 [Access: April 21, 2024]. doi:10.5455/OVJ.2024.v14.i2.3

AMA (American Medical Association) Style

Othmen ZOB, JERBI MA, Timoumi R, Besbes R, Haouas Z, Achour L, Elazomi A, Zaet A, Zourgui L, Kacem A. Liver histopathological and oxidative stress assessment by a combination of formaldehyde and oxytetracycline in sea bass (Dicentrarchuslabrax L). Open Vet J. 2024; 14(2): 630-639. doi:10.5455/OVJ.2024.v14.i2.3


Vancouver/ICMJE Style

Othmen ZOB, JERBI MA, Timoumi R, Besbes R, Haouas Z, Achour L, Elazomi A, Zaet A, Zourgui L, Kacem A. Liver histopathological and oxidative stress assessment by a combination of formaldehyde and oxytetracycline in sea bass (Dicentrarchuslabrax L). Open Vet J. (2024), [cited April 21, 2024]; 14(2): 630-639. doi:10.5455/OVJ.2024.v14.i2.3


Harvard Style

Othmen, Z. O. B., JERBI, . M. A., Timoumi, . R., Besbes, . R., Haouas, . Z., Achour, . L., Elazomi, . A., Zaet, . A., Zourgui, . L. & Kacem, . A. (2024) Liver histopathological and oxidative stress assessment by a combination of formaldehyde and oxytetracycline in sea bass (Dicentrarchuslabrax L). Open Vet J, 14 (2), 630-639. doi:10.5455/OVJ.2024.v14.i2.3


Turabian Style

Othmen, Zouhour Ouanes Ben, Mohamed Ali JERBI, Rim Timoumi, Raouf Besbes, Zohra Haouas, Lotfi Achour, Altayeb Elazomi, Abdurraouf Zaet, Lazhar Zourgui, and Adnen Kacem. 2024. Liver histopathological and oxidative stress assessment by a combination of formaldehyde and oxytetracycline in sea bass (Dicentrarchuslabrax L). Open Veterinary Journal, 14 (2), 630-639. doi:10.5455/OVJ.2024.v14.i2.3


Chicago Style

Othmen, Zouhour Ouanes Ben, Mohamed Ali JERBI, Rim Timoumi, Raouf Besbes, Zohra Haouas, Lotfi Achour, Altayeb Elazomi, Abdurraouf Zaet, Lazhar Zourgui, and Adnen Kacem. "Liver histopathological and oxidative stress assessment by a combination of formaldehyde and oxytetracycline in sea bass (Dicentrarchuslabrax L)." Open Veterinary Journal 14 (2024), 630-639. doi:10.5455/OVJ.2024.v14.i2.3


MLA (The Modern Language Association) Style

Othmen, Zouhour Ouanes Ben, Mohamed Ali JERBI, Rim Timoumi, Raouf Besbes, Zohra Haouas, Lotfi Achour, Altayeb Elazomi, Abdurraouf Zaet, Lazhar Zourgui, and Adnen Kacem. "Liver histopathological and oxidative stress assessment by a combination of formaldehyde and oxytetracycline in sea bass (Dicentrarchuslabrax L)." Open Veterinary Journal 14.2 (2024), 630-639. Print. doi:10.5455/OVJ.2024.v14.i2.3


APA (American Psychological Association) Style

Othmen, Z. O. B., JERBI, . M. A., Timoumi, . R., Besbes, . R., Haouas, . Z., Achour, . L., Elazomi, . A., Zaet, . A., Zourgui, . L. & Kacem, . A. (2024) Liver histopathological and oxidative stress assessment by a combination of formaldehyde and oxytetracycline in sea bass (Dicentrarchuslabrax L). Open Veterinary Journal, 14 (2), 630-639. doi:10.5455/OVJ.2024.v14.i2.3


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