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Research Article


Secretome of bovine umbilical vein endothelial cells promote wound healing regeneration on the second degree rat model burn injury

Mavheena Moghan, Paarvaishnee Naidu, Nadhrah Binti Zulkifly, Yulfia Nelymalik Selan, Erif Maha Nugraha Setyawan, Sugi Winarsih, Dwi Liliek Kusindarta.


Abstract
Background:
Burn injuries are an alarming indicator of the sensitivity of human tissue when confronted with high temperatures or chemicals. The current treatment for burn wounds needs to be improved and more extensive in scope. Significant research advances concerning the therapeutic potential of secretomes over the past two decades have expanded the range of therapies that utilize secretomes to encompass populations other than stem cells.
Aim:
This study details how the secretome extracted from the Bovine Umbilical Vein Endothelial Cell (BUVEC) promotes the healing of burn injuries.
Methods:
The 48 rats were divided into four groups, namely the control group with povidone-iodine, the 5% BUVEC-CM cream group, the 10% BUVEC-CM cream group, the 15% BUVEC-CM cream group. Animals induced type II burns under anesthesia. Treatment is carried out topically, 2 times a day. Every day the wound was measured. The animals were put to sleep for samples on days 5, 13, 21, and 19. Samples in the form of skins were soaked in 4% paraformaldehyde and processed with paraffin-embedded for tissue preparations. The research results were processed using Two Ways ANOVA.
Results:
The study showed that on day 5, wound closure occurred, whereas in the povidone-iodine group, macroscopically, the wound closed faster. Epithelial repair, increased fibroblasts and collagen, and blood vessel formation greatly increased in the 15% BUVEC-CM group on days 13, 21, and 29.
Conclusion:
Taken together, BUVEC secretome promoted fibroblast regeneration, collagen formation, re-epithelialization, and hair follicle regeneration on the burn injury wound healing.

Key words: Secretome, BUVEC, Burn wound, Rat model, Remodeling


 
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How to Cite this Article
Pubmed Style

Moghan M, Naidu P, Zulkifly NB, Selan YN, Setyawan EMN, Winarsih S, Kusindarta DL. Secretome of bovine umbilical vein endothelial cells promote wound healing regeneration on the second degree rat model burn injury. Open Vet J. 2023; 13(12): 1597-1606. doi:10.5455/OVJ.2023.v13.i12.9

Web Style

Moghan M, Naidu P, Zulkifly NB, Selan YN, Setyawan EMN, Winarsih S, Kusindarta DL. Secretome of bovine umbilical vein endothelial cells promote wound healing regeneration on the second degree rat model burn injury. https://www.openveterinaryjournal.com/?mno=165991 [Access: January 23, 2025]. doi:10.5455/OVJ.2023.v13.i12.9

AMA (American Medical Association) Style

Moghan M, Naidu P, Zulkifly NB, Selan YN, Setyawan EMN, Winarsih S, Kusindarta DL. Secretome of bovine umbilical vein endothelial cells promote wound healing regeneration on the second degree rat model burn injury. Open Vet J. 2023; 13(12): 1597-1606. doi:10.5455/OVJ.2023.v13.i12.9


Vancouver/ICMJE Style

Moghan M, Naidu P, Zulkifly NB, Selan YN, Setyawan EMN, Winarsih S, Kusindarta DL. Secretome of bovine umbilical vein endothelial cells promote wound healing regeneration on the second degree rat model burn injury. Open Vet J. (2023), [cited January 23, 2025]; 13(12): 1597-1606. doi:10.5455/OVJ.2023.v13.i12.9


Harvard Style

Moghan, M., Naidu, . P., Zulkifly, . N. B., Selan, . Y. N., Setyawan, . E. M. N., Winarsih, . S. & Kusindarta, . D. L. (2023) Secretome of bovine umbilical vein endothelial cells promote wound healing regeneration on the second degree rat model burn injury. Open Vet J, 13 (12), 1597-1606. doi:10.5455/OVJ.2023.v13.i12.9


Turabian Style

Moghan, Mavheena, Paarvaishnee Naidu, Nadhrah Binti Zulkifly, Yulfia Nelymalik Selan, Erif Maha Nugraha Setyawan, Sugi Winarsih, and Dwi Liliek Kusindarta. 2023. Secretome of bovine umbilical vein endothelial cells promote wound healing regeneration on the second degree rat model burn injury. Open Veterinary Journal, 13 (12), 1597-1606. doi:10.5455/OVJ.2023.v13.i12.9


Chicago Style

Moghan, Mavheena, Paarvaishnee Naidu, Nadhrah Binti Zulkifly, Yulfia Nelymalik Selan, Erif Maha Nugraha Setyawan, Sugi Winarsih, and Dwi Liliek Kusindarta. "Secretome of bovine umbilical vein endothelial cells promote wound healing regeneration on the second degree rat model burn injury." Open Veterinary Journal 13 (2023), 1597-1606. doi:10.5455/OVJ.2023.v13.i12.9


MLA (The Modern Language Association) Style

Moghan, Mavheena, Paarvaishnee Naidu, Nadhrah Binti Zulkifly, Yulfia Nelymalik Selan, Erif Maha Nugraha Setyawan, Sugi Winarsih, and Dwi Liliek Kusindarta. "Secretome of bovine umbilical vein endothelial cells promote wound healing regeneration on the second degree rat model burn injury." Open Veterinary Journal 13.12 (2023), 1597-1606. Print. doi:10.5455/OVJ.2023.v13.i12.9


APA (American Psychological Association) Style

Moghan, M., Naidu, . P., Zulkifly, . N. B., Selan, . Y. N., Setyawan, . E. M. N., Winarsih, . S. & Kusindarta, . D. L. (2023) Secretome of bovine umbilical vein endothelial cells promote wound healing regeneration on the second degree rat model burn injury. Open Veterinary Journal, 13 (12), 1597-1606. doi:10.5455/OVJ.2023.v13.i12.9


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