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2025, Vol: 15, Issue: 4
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Original Article


Serological survey on Bovine viral diarrhea virus in man and evaluation of relation with Zika virus associated microcephaly

Massimo Giangaspero, Tamaki Okabayashi.


Cited By:1

Abstract
Background:
In 2015, an unprecedented epidemic of microcephaly occurred in Brazil. Preliminary observations suggested involvement of cofactors in the etiopathology of Zika virus associated microcephaly. Bovine viral diarrhea virus (BVDV) was identified in fetal samples with microcephaly, originating in the state of Paraíba, and two virus sequences, obtained from the amniotic fluid collected from mothers with babies affected by Zika and microcephaly, have been characterized as two different species of BVDV, types 1 and 2.
Aim:
The involvement of BVDV as co-factor in the etiopathogenesis of Zika virus associated microcephaly was explored.
Methods:
A serological screening using an ELISA test was undertaken to detect antibodies against BVDV among patients referred to the Central laboratory of Natal, Rio Grande do Norte, encompassing microcephalic babies and their mothers, mothers and pregnant not associated with microcephaly and general patients as control group.
Results:
Two samples were positive, out of 382 tested, (0.52%). No specific relation with birth-defects could be established.
Conclusion:
The study might suggest serological evidence of the circulation of BVDV in humans. Further studies and application of improved diagnostic tests adapted to humans are necessary to clarify the epidemiological extent and impact of BVDV.

Key words: Bovine Viral Diarrhea Virus (BVDV), Brazil, Cofactor, Microcephaly, Zika virus


 
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How to Cite this Article
Pubmed Style

Giangaspero M, Okabayashi T. Serological survey on Bovine viral diarrhea virus in man and evaluation of relation with Zika virus associated microcephaly. Open Vet J. 2023; 13(4): 400-406. doi:10.5455/OVJ.2023.v13.i4.1

Web Style

Giangaspero M, Okabayashi T. Serological survey on Bovine viral diarrhea virus in man and evaluation of relation with Zika virus associated microcephaly. https://www.openveterinaryjournal.com/?mno=17125 [Access: May 08, 2025]. doi:10.5455/OVJ.2023.v13.i4.1

AMA (American Medical Association) Style

Giangaspero M, Okabayashi T. Serological survey on Bovine viral diarrhea virus in man and evaluation of relation with Zika virus associated microcephaly. Open Vet J. 2023; 13(4): 400-406. doi:10.5455/OVJ.2023.v13.i4.1


Vancouver/ICMJE Style

Giangaspero M, Okabayashi T. Serological survey on Bovine viral diarrhea virus in man and evaluation of relation with Zika virus associated microcephaly. Open Vet J. (2023), [cited May 08, 2025]; 13(4): 400-406. doi:10.5455/OVJ.2023.v13.i4.1


Harvard Style

Giangaspero, M. & Okabayashi, . T. (2023) Serological survey on Bovine viral diarrhea virus in man and evaluation of relation with Zika virus associated microcephaly. Open Vet J, 13 (4), 400-406. doi:10.5455/OVJ.2023.v13.i4.1


Turabian Style

Giangaspero, Massimo, and Tamaki Okabayashi. 2023. Serological survey on Bovine viral diarrhea virus in man and evaluation of relation with Zika virus associated microcephaly. Open Veterinary Journal, 13 (4), 400-406. doi:10.5455/OVJ.2023.v13.i4.1


Chicago Style

Giangaspero, Massimo, and Tamaki Okabayashi. "Serological survey on Bovine viral diarrhea virus in man and evaluation of relation with Zika virus associated microcephaly." Open Veterinary Journal 13 (2023), 400-406. doi:10.5455/OVJ.2023.v13.i4.1


MLA (The Modern Language Association) Style

Giangaspero, Massimo, and Tamaki Okabayashi. "Serological survey on Bovine viral diarrhea virus in man and evaluation of relation with Zika virus associated microcephaly." Open Veterinary Journal 13.4 (2023), 400-406. Print. doi:10.5455/OVJ.2023.v13.i4.1


APA (American Psychological Association) Style

Giangaspero, M. & Okabayashi, . T. (2023) Serological survey on Bovine viral diarrhea virus in man and evaluation of relation with Zika virus associated microcephaly. Open Veterinary Journal, 13 (4), 400-406. doi:10.5455/OVJ.2023.v13.i4.1


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