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Research Article


The effect of butyric acid and nucleotides supplementation on broiler (Gallus gallus domesticus) growth performance, immune status, intestinal histology, and serum parameters

Ahmed A.M. Abdel-Aziz, El-Sayed A. Abdel-Aziz, Mohamed H. Khairy, Charbel Fadel, Mario Giorgi, Ahmed S. Abdelaziz.


Abstract
Background:
Butyric acid and its derivatives support the immune system, lessen inflammation, and lessen oxidative stress in broilers in addition to preserving gut homeostasis and epithelial integrity. Broiler performance has also been demonstrated to rise with the addition of nucleotides to the diet.
Aim:
The purpose of the study was to ascertain the effects of butyric acid and nucleotides added to feed on the overall performance, immunity, oxidant/antioxidant enzyme levels, intestinal histology, and hepatic functions of broilers.
Methods:
Four experimental groups of thirty chickens, each were used in the present study. The groups were assigned as a control group that received normal diet without additives, butyrate (B) group received the diet supplemented with butyric acid (250 g/ton feed), nucleotides (N) group received the diet supplemented with nucleotides (200 g/ton feed), and the fourth group received the diet supplemented with a combination of butyrate and nucleotide (BN) (250 g/ton B feed, and 200 g/ton N feed, respectively). Necrotic enteritis was produced in ten birds from each group to assess the immune-modulatory effect of these supplements, antioxidant status, intestinal histology and liver functions were measured in all experimental groups.
Results:
The addition of butyric acid and nucleotides to feed enhanced body weight, growth performance, hepatic functions, and antioxidant capabilities. Histological sections of the gut from challenged or unchallenged (with necrotic enteritis) groups in the BN group showed considerable improvement, as shown by strong proliferation in intestinal crypts and villus enterocytes.
Conclusion:
Nucleotides and butyric acid can be added to broiler feeding regimens to enhance growth and health.

Key words: Nucleotides, Growth performance, Immunity, Butyric acid, Broiler nutrition


 
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How to Cite this Article
Pubmed Style

Abdel-Aziz AA, Abdel-Aziz EA, Khairy MH, Fadel C, Giorgi M, Abdelaziz AS. The effect of butyric acid and nucleotides supplementation on broiler (Gallus gallus domesticus) growth performance, immune status, intestinal histology, and serum parameters. Open Vet J. 2024; 14((1) (Zagazig Veterinary Conference)): 324-334. doi:10.5455/OVJ.2024.v14.i1.29

Web Style

Abdel-Aziz AA, Abdel-Aziz EA, Khairy MH, Fadel C, Giorgi M, Abdelaziz AS. The effect of butyric acid and nucleotides supplementation on broiler (Gallus gallus domesticus) growth performance, immune status, intestinal histology, and serum parameters. https://www.openveterinaryjournal.com/?mno=178050 [Access: May 03, 2024]. doi:10.5455/OVJ.2024.v14.i1.29

AMA (American Medical Association) Style

Abdel-Aziz AA, Abdel-Aziz EA, Khairy MH, Fadel C, Giorgi M, Abdelaziz AS. The effect of butyric acid and nucleotides supplementation on broiler (Gallus gallus domesticus) growth performance, immune status, intestinal histology, and serum parameters. Open Vet J. 2024; 14((1) (Zagazig Veterinary Conference)): 324-334. doi:10.5455/OVJ.2024.v14.i1.29


Vancouver/ICMJE Style

Abdel-Aziz AA, Abdel-Aziz EA, Khairy MH, Fadel C, Giorgi M, Abdelaziz AS. The effect of butyric acid and nucleotides supplementation on broiler (Gallus gallus domesticus) growth performance, immune status, intestinal histology, and serum parameters. Open Vet J. (2024), [cited May 03, 2024]; 14((1) (Zagazig Veterinary Conference)): 324-334. doi:10.5455/OVJ.2024.v14.i1.29


Harvard Style

Abdel-Aziz, A. A., Abdel-Aziz, . E. A., Khairy, . M. H., Fadel, . C., Giorgi, . M. & Abdelaziz, . A. S. (2024) The effect of butyric acid and nucleotides supplementation on broiler (Gallus gallus domesticus) growth performance, immune status, intestinal histology, and serum parameters. Open Vet J, 14 ((1) (Zagazig Veterinary Conference)), 324-334. doi:10.5455/OVJ.2024.v14.i1.29


Turabian Style

Abdel-Aziz, Ahmed A.M., El-Sayed A. Abdel-Aziz, Mohamed H. Khairy, Charbel Fadel, Mario Giorgi, and Ahmed S. Abdelaziz. 2024. The effect of butyric acid and nucleotides supplementation on broiler (Gallus gallus domesticus) growth performance, immune status, intestinal histology, and serum parameters. Open Veterinary Journal, 14 ((1) (Zagazig Veterinary Conference)), 324-334. doi:10.5455/OVJ.2024.v14.i1.29


Chicago Style

Abdel-Aziz, Ahmed A.M., El-Sayed A. Abdel-Aziz, Mohamed H. Khairy, Charbel Fadel, Mario Giorgi, and Ahmed S. Abdelaziz. "The effect of butyric acid and nucleotides supplementation on broiler (Gallus gallus domesticus) growth performance, immune status, intestinal histology, and serum parameters." Open Veterinary Journal 14 (2024), 324-334. doi:10.5455/OVJ.2024.v14.i1.29


MLA (The Modern Language Association) Style

Abdel-Aziz, Ahmed A.M., El-Sayed A. Abdel-Aziz, Mohamed H. Khairy, Charbel Fadel, Mario Giorgi, and Ahmed S. Abdelaziz. "The effect of butyric acid and nucleotides supplementation on broiler (Gallus gallus domesticus) growth performance, immune status, intestinal histology, and serum parameters." Open Veterinary Journal 14.(1) (Zagazig Veterinary Conference) (2024), 324-334. Print. doi:10.5455/OVJ.2024.v14.i1.29


APA (American Psychological Association) Style

Abdel-Aziz, A. A., Abdel-Aziz, . E. A., Khairy, . M. H., Fadel, . C., Giorgi, . M. & Abdelaziz, . A. S. (2024) The effect of butyric acid and nucleotides supplementation on broiler (Gallus gallus domesticus) growth performance, immune status, intestinal histology, and serum parameters. Open Veterinary Journal, 14 ((1) (Zagazig Veterinary Conference)), 324-334. doi:10.5455/OVJ.2024.v14.i1.29


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