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Research Article


Pathological, histochemical, and immune-histochemical studies on some canine-skin neoplasm at Sharkia province, Egypt

Hatem A. Zwai, Al-Sayed R. Al-Attar, Abdulla E. Morsi, Moustafa S. Abou-El-Fetouh.


Abstract
Background:
Cutaneous neoplastic disorders are often observed in small mammal pets, such as dogs, regardless of their gender.
Aim:
An important objective of this work was to give a full account of clinical, pathological, and immune-histochemical features of several skin tumours in dogs.
Methods:
This study was a case series in the hospital clinic, Faculty of Veterinary Medicine, Zagazig University, Egypt. Twenty-five dogs (14 males, and 11 females) were examined clinically during the period from March 2022 to October 2023. The skin swelling was collected from affected animals and then subjected to a detailed histopathological study to record the different gross and microscopic findings and confirmed the diagnosis by immunohistochemistry.
Results:
Skin neoplasia in dogs was exposed to various clinical signs, and the dogs' ages ranged between 3 to 11 years. Concerning tumor features, the majority of neoplasms were malignant (65.52%) more than benign (34.48%).The study revealed the presence of 29 cases of dogs showed neoplasia with different prevalence rate including squamous cell carcinoma (13.79%), mast cell tumor (6.89%), basal cell tumours (10.34%), histiocytoma (6.89%), trichoepithelioma (10.34%), transmissible venereal tumor (10.34%), trichilemmoma (3.44%), scalp paraganglioma (3.44%), pilomatricoma (10.34%), malignant melanomas (17.24%), and miscellaneous cases as fat necrosis (6.89%), in males and females dogs with different histopathological lesions and immunohistochemistry expressions for Pan-Cytokeratin (CK), melanocyte-differentiation antigens (S100 protein) and synaptophysin.
Conclusion:
Malignant melanomas (17.24%) are the extreme common cutaneous tumor diagnosed in this study. Meanwhile, benign tumors such as trichilemmoma, trichoepithelioma, pilomatricoma, and paraganglioma are less frequent in dogs.

Key words: Dogs, Skin tumors, Trichoepithelioma, Paraganglioma, Melanoma


 
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How to Cite this Article
Pubmed Style

Zwai HA, Al-Attar AR, Morsi AE, Abou-El-Fetouh MS. Pathological, histochemical, and immune-histochemical studies on some canine-skin neoplasm at Sharkia province, Egypt. Open Vet J. 2024; 14((1) (Zagazig Veterinary Conference)): 481-499. doi:10.5455/OVJ.2024.v14.i1.44

Web Style

Zwai HA, Al-Attar AR, Morsi AE, Abou-El-Fetouh MS. Pathological, histochemical, and immune-histochemical studies on some canine-skin neoplasm at Sharkia province, Egypt. https://www.openveterinaryjournal.com/?mno=182392 [Access: May 02, 2024]. doi:10.5455/OVJ.2024.v14.i1.44

AMA (American Medical Association) Style

Zwai HA, Al-Attar AR, Morsi AE, Abou-El-Fetouh MS. Pathological, histochemical, and immune-histochemical studies on some canine-skin neoplasm at Sharkia province, Egypt. Open Vet J. 2024; 14((1) (Zagazig Veterinary Conference)): 481-499. doi:10.5455/OVJ.2024.v14.i1.44


Vancouver/ICMJE Style

Zwai HA, Al-Attar AR, Morsi AE, Abou-El-Fetouh MS. Pathological, histochemical, and immune-histochemical studies on some canine-skin neoplasm at Sharkia province, Egypt. Open Vet J. (2024), [cited May 02, 2024]; 14((1) (Zagazig Veterinary Conference)): 481-499. doi:10.5455/OVJ.2024.v14.i1.44


Harvard Style

Zwai, H. A., Al-Attar, . A. R., Morsi, . A. E. & Abou-El-Fetouh, . M. S. (2024) Pathological, histochemical, and immune-histochemical studies on some canine-skin neoplasm at Sharkia province, Egypt. Open Vet J, 14 ((1) (Zagazig Veterinary Conference)), 481-499. doi:10.5455/OVJ.2024.v14.i1.44


Turabian Style

Zwai, Hatem A., Al-Sayed R. Al-Attar, Abdulla E. Morsi, and Moustafa S. Abou-El-Fetouh. 2024. Pathological, histochemical, and immune-histochemical studies on some canine-skin neoplasm at Sharkia province, Egypt. Open Veterinary Journal, 14 ((1) (Zagazig Veterinary Conference)), 481-499. doi:10.5455/OVJ.2024.v14.i1.44


Chicago Style

Zwai, Hatem A., Al-Sayed R. Al-Attar, Abdulla E. Morsi, and Moustafa S. Abou-El-Fetouh. "Pathological, histochemical, and immune-histochemical studies on some canine-skin neoplasm at Sharkia province, Egypt." Open Veterinary Journal 14 (2024), 481-499. doi:10.5455/OVJ.2024.v14.i1.44


MLA (The Modern Language Association) Style

Zwai, Hatem A., Al-Sayed R. Al-Attar, Abdulla E. Morsi, and Moustafa S. Abou-El-Fetouh. "Pathological, histochemical, and immune-histochemical studies on some canine-skin neoplasm at Sharkia province, Egypt." Open Veterinary Journal 14.(1) (Zagazig Veterinary Conference) (2024), 481-499. Print. doi:10.5455/OVJ.2024.v14.i1.44


APA (American Psychological Association) Style

Zwai, H. A., Al-Attar, . A. R., Morsi, . A. E. & Abou-El-Fetouh, . M. S. (2024) Pathological, histochemical, and immune-histochemical studies on some canine-skin neoplasm at Sharkia province, Egypt. Open Veterinary Journal, 14 ((1) (Zagazig Veterinary Conference)), 481-499. doi:10.5455/OVJ.2024.v14.i1.44


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