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Can silver nanoparticles stabilized by Fenugreek (Trigonella foenm -graecum) improve tibial bone defects repair in rabbits? A preliminary study

Madeh Sadan, Mommen Naem, Hesham M. Tawfeek, Mostafa M. Khodier, Moustafa M. Zeitoun, Sabry El-Khodery, Abdullah S. Alkhamiss, Yaser A.H. Hassan, Ahmed A.H. Abdellatif.


Abstract
Background:
A fracture is considered a medical emergency leading to considerable complications.
Aim:
This study aimed to describe the accelerating action of Ag-NPs-FG on fracture healing in rabbits.
Methods:
AgNPs were reduced with FG, loaded into a starch gel base, and investigated for their morphology, size, and charge. Four equal groups were randomly formed of 40 adult male rabbits. A 3.5 mm diameter bone defect was created at the proximal metaphysis the right tibia in each rabbit. Groups 1 to 4 were injected with placebo saline, AgNPs-FG, plain gel, and FG-gel at the bone defect zone, respectively. The healing was assessed for 8 weeks postoperatively based on the radiographic, bone turnover markers, and histopathological examinations.
Results:
The AgNPs-FG was obtained as a faint reddish color, spherical in shape, with an absorbance of 423 nm, a size of 118.0±1.7 nm, and a surface charge of -7.8±0.518 mV. The prepared AgNPs-FG hydrogel was clear, translucent, and homogenous. The pH values were 6.55-6.5±0.2, the viscosity of 4000 and 1875 cPs, and spreadability of 1.6±0.14 and 2.0±0.15 for both FG and AgNPs-FG hydrogel, respectively. Radiographic union scale was significantly (p<0.05) improved in group 2 with significant (P < 0.05) increase of bone turnover markers was found in comparison to other treated groups. Histopathological examination revealed the formation of mature bone on the 28th postoperative day in groups 2 and 4.
Conclusion:
Colloidal nano-formulation of AgNPs-FG loaded hydrogel could be a promising formulation to accelerate rabbits' tibial bone healing process.

Key words: Animals, Diagnostic imaging, Fenugreek, Radiography, Silver nanoparticles


 
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How to Cite this Article
Pubmed Style

Sadan M, Naem M, Tawfeek HM, Khodier MM, Zeitoun MM, El-Khodery S, Alkhamiss AS, Hassan YA, Abdellatif AA. Can silver nanoparticles stabilized by Fenugreek (Trigonella foenm -graecum) improve tibial bone defects repair in rabbits? A preliminary study. Open Vet J. 2024; 14(5): 1281-1293. doi:10.5455/OVJ.2024.v14.i5.23

Web Style

Sadan M, Naem M, Tawfeek HM, Khodier MM, Zeitoun MM, El-Khodery S, Alkhamiss AS, Hassan YA, Abdellatif AA. Can silver nanoparticles stabilized by Fenugreek (Trigonella foenm -graecum) improve tibial bone defects repair in rabbits? A preliminary study. https://www.openveterinaryjournal.com/?mno=194332 [Access: June 21, 2024]. doi:10.5455/OVJ.2024.v14.i5.23

AMA (American Medical Association) Style

Sadan M, Naem M, Tawfeek HM, Khodier MM, Zeitoun MM, El-Khodery S, Alkhamiss AS, Hassan YA, Abdellatif AA. Can silver nanoparticles stabilized by Fenugreek (Trigonella foenm -graecum) improve tibial bone defects repair in rabbits? A preliminary study. Open Vet J. 2024; 14(5): 1281-1293. doi:10.5455/OVJ.2024.v14.i5.23


Vancouver/ICMJE Style

Sadan M, Naem M, Tawfeek HM, Khodier MM, Zeitoun MM, El-Khodery S, Alkhamiss AS, Hassan YA, Abdellatif AA. Can silver nanoparticles stabilized by Fenugreek (Trigonella foenm -graecum) improve tibial bone defects repair in rabbits? A preliminary study. Open Vet J. (2024), [cited June 21, 2024]; 14(5): 1281-1293. doi:10.5455/OVJ.2024.v14.i5.23


Harvard Style

Sadan, M., Naem, . M., Tawfeek, . H. M., Khodier, . M. M., Zeitoun, . M. M., El-Khodery, . S., Alkhamiss, . A. S., Hassan, . Y. A. & Abdellatif, . A. A. (2024) Can silver nanoparticles stabilized by Fenugreek (Trigonella foenm -graecum) improve tibial bone defects repair in rabbits? A preliminary study. Open Vet J, 14 (5), 1281-1293. doi:10.5455/OVJ.2024.v14.i5.23


Turabian Style

Sadan, Madeh, Mommen Naem, Hesham M. Tawfeek, Mostafa M. Khodier, Moustafa M. Zeitoun, Sabry El-Khodery, Abdullah S. Alkhamiss, Yaser A.H. Hassan, and Ahmed A.H. Abdellatif. 2024. Can silver nanoparticles stabilized by Fenugreek (Trigonella foenm -graecum) improve tibial bone defects repair in rabbits? A preliminary study. Open Veterinary Journal, 14 (5), 1281-1293. doi:10.5455/OVJ.2024.v14.i5.23


Chicago Style

Sadan, Madeh, Mommen Naem, Hesham M. Tawfeek, Mostafa M. Khodier, Moustafa M. Zeitoun, Sabry El-Khodery, Abdullah S. Alkhamiss, Yaser A.H. Hassan, and Ahmed A.H. Abdellatif. "Can silver nanoparticles stabilized by Fenugreek (Trigonella foenm -graecum) improve tibial bone defects repair in rabbits? A preliminary study." Open Veterinary Journal 14 (2024), 1281-1293. doi:10.5455/OVJ.2024.v14.i5.23


MLA (The Modern Language Association) Style

Sadan, Madeh, Mommen Naem, Hesham M. Tawfeek, Mostafa M. Khodier, Moustafa M. Zeitoun, Sabry El-Khodery, Abdullah S. Alkhamiss, Yaser A.H. Hassan, and Ahmed A.H. Abdellatif. "Can silver nanoparticles stabilized by Fenugreek (Trigonella foenm -graecum) improve tibial bone defects repair in rabbits? A preliminary study." Open Veterinary Journal 14.5 (2024), 1281-1293. Print. doi:10.5455/OVJ.2024.v14.i5.23


APA (American Psychological Association) Style

Sadan, M., Naem, . M., Tawfeek, . H. M., Khodier, . M. M., Zeitoun, . M. M., El-Khodery, . S., Alkhamiss, . A. S., Hassan, . Y. A. & Abdellatif, . A. A. (2024) Can silver nanoparticles stabilized by Fenugreek (Trigonella foenm -graecum) improve tibial bone defects repair in rabbits? A preliminary study. Open Veterinary Journal, 14 (5), 1281-1293. doi:10.5455/OVJ.2024.v14.i5.23


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