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Research Article


Ethyl acetate extract of fungus comb from Malayan termite (Macrotermes gilvus Hagen) mound modulates splenic inflammatory responses in mice

Hermawan Susanto, Jeferson Caesario, Decsa Medika Hertanto, Ketut Sudiana, Kukuh Dwiputra Hernugrahanto, Dwikora Novembri Utomo, Nicolaas Cyrillus Budhiparama, Ahmad Dzulfikri Nurhan, Mahardian Rahmadi, Dodi Nandika, Lina Karlinasari, Arinana Arinana, Irmanida Batubara, Lucia Dhiantika Witasari, Yanti Rachmayanti, Dikhi Firmasyah, Sairah Abdul Karim, Indang Ariati Ariffin, Djoko Santoso.


Abstract
Background:
The fungus comb is a unique structure inside termites’ nests that facilitates the growth of Termitomyces sp. as a nutrient source for the termites. It is known to possess immunomodulatory properties that boost the immune system.
Aim:
This objective of this study was to assess the impact of ethyl acetate extract of fungus comb (EAEFC) on the inflammatory reaction in the spleen of mice induced by intraperitoneal injection of lipopolysaccharide (LPS).
Methods:
An experimental study was conducted using a post-test-only control group design with male BALB/C mice (n=24). The mice were divided randomly into four groups, each comprising six mice, and administered substances via gavage. Groups I and III were administered a solution of 5% dimethyl sulfoxide (DMSO) in distilled water, while Groups II and IV were given 500 mg/kg BW EAEFC dissolved in 5% DMSO. On the fifteenth day, Groups I and II received intraperitoneal injection of 5 ml/kg BW saline, while Groups III and IV were injected with 10 mg/kg BW lipopolysaccharide (LPS) dissolved in saline. After three hours, the mice were euthanized and splenic immunohistology was examined under a light microscope. The results were expressed as mean ± standard deviation (SD), while the group differences were assessed statistically.
Results:
The expression of interleukin (IL)-1, furin, and activated NK cell was significantly higher in the inflamed model after EAEFC supplementation, while the extract suppressed IL-10.
Conclusion:
EAEFC was found to alter cytokine expression in the spleen in response to inflammation.

Key words: Fungus comb, Lipopolysaccharide, Inflammation, Interleukin, Cytokine


 
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How to Cite this Article
Pubmed Style

Susanto H, Caesario J, Hertanto DM, Sudiana K, Hernugrahanto KD, Utomo DN, Budhiparama NC, Nurhan AD, Rahmadi M, Nandika D, Karlinasari L, Arinana A, Batubara I, Witasari LD, Rachmayanti Y, Firmasyah D, Karim SA, Ariffin IA, Santoso D. Ethyl acetate extract of fungus comb from Malayan termite (Macrotermes gilvus Hagen) mound modulates splenic inflammatory responses in mice. Open Vet J. 2024; 14(9): 2269-2279. doi:10.5455/OVJ.2024.v14.i9.15

Web Style

Susanto H, Caesario J, Hertanto DM, Sudiana K, Hernugrahanto KD, Utomo DN, Budhiparama NC, Nurhan AD, Rahmadi M, Nandika D, Karlinasari L, Arinana A, Batubara I, Witasari LD, Rachmayanti Y, Firmasyah D, Karim SA, Ariffin IA, Santoso D. Ethyl acetate extract of fungus comb from Malayan termite (Macrotermes gilvus Hagen) mound modulates splenic inflammatory responses in mice. https://www.openveterinaryjournal.com/?mno=196567 [Access: October 03, 2024]. doi:10.5455/OVJ.2024.v14.i9.15

AMA (American Medical Association) Style

Susanto H, Caesario J, Hertanto DM, Sudiana K, Hernugrahanto KD, Utomo DN, Budhiparama NC, Nurhan AD, Rahmadi M, Nandika D, Karlinasari L, Arinana A, Batubara I, Witasari LD, Rachmayanti Y, Firmasyah D, Karim SA, Ariffin IA, Santoso D. Ethyl acetate extract of fungus comb from Malayan termite (Macrotermes gilvus Hagen) mound modulates splenic inflammatory responses in mice. Open Vet J. 2024; 14(9): 2269-2279. doi:10.5455/OVJ.2024.v14.i9.15


Vancouver/ICMJE Style

Susanto H, Caesario J, Hertanto DM, Sudiana K, Hernugrahanto KD, Utomo DN, Budhiparama NC, Nurhan AD, Rahmadi M, Nandika D, Karlinasari L, Arinana A, Batubara I, Witasari LD, Rachmayanti Y, Firmasyah D, Karim SA, Ariffin IA, Santoso D. Ethyl acetate extract of fungus comb from Malayan termite (Macrotermes gilvus Hagen) mound modulates splenic inflammatory responses in mice. Open Vet J. (2024), [cited October 03, 2024]; 14(9): 2269-2279. doi:10.5455/OVJ.2024.v14.i9.15


Harvard Style

Susanto, H., Caesario, . J., Hertanto, . D. M., Sudiana, . K., Hernugrahanto, . K. D., Utomo, . D. N., Budhiparama, . N. C., Nurhan, . A. D., Rahmadi, . M., Nandika, . D., Karlinasari, . L., Arinana, . A., Batubara, . I., Witasari, . L. D., Rachmayanti, . Y., Firmasyah, . D., Karim, . S. A., Ariffin, . I. A. & Santoso, . D. (2024) Ethyl acetate extract of fungus comb from Malayan termite (Macrotermes gilvus Hagen) mound modulates splenic inflammatory responses in mice. Open Vet J, 14 (9), 2269-2279. doi:10.5455/OVJ.2024.v14.i9.15


Turabian Style

Susanto, Hermawan, Jeferson Caesario, Decsa Medika Hertanto, Ketut Sudiana, Kukuh Dwiputra Hernugrahanto, Dwikora Novembri Utomo, Nicolaas Cyrillus Budhiparama, Ahmad Dzulfikri Nurhan, Mahardian Rahmadi, Dodi Nandika, Lina Karlinasari, Arinana Arinana, Irmanida Batubara, Lucia Dhiantika Witasari, Yanti Rachmayanti, Dikhi Firmasyah, Sairah Abdul Karim, Indang Ariati Ariffin, and Djoko Santoso. 2024. Ethyl acetate extract of fungus comb from Malayan termite (Macrotermes gilvus Hagen) mound modulates splenic inflammatory responses in mice. Open Veterinary Journal, 14 (9), 2269-2279. doi:10.5455/OVJ.2024.v14.i9.15


Chicago Style

Susanto, Hermawan, Jeferson Caesario, Decsa Medika Hertanto, Ketut Sudiana, Kukuh Dwiputra Hernugrahanto, Dwikora Novembri Utomo, Nicolaas Cyrillus Budhiparama, Ahmad Dzulfikri Nurhan, Mahardian Rahmadi, Dodi Nandika, Lina Karlinasari, Arinana Arinana, Irmanida Batubara, Lucia Dhiantika Witasari, Yanti Rachmayanti, Dikhi Firmasyah, Sairah Abdul Karim, Indang Ariati Ariffin, and Djoko Santoso. "Ethyl acetate extract of fungus comb from Malayan termite (Macrotermes gilvus Hagen) mound modulates splenic inflammatory responses in mice." Open Veterinary Journal 14 (2024), 2269-2279. doi:10.5455/OVJ.2024.v14.i9.15


MLA (The Modern Language Association) Style

Susanto, Hermawan, Jeferson Caesario, Decsa Medika Hertanto, Ketut Sudiana, Kukuh Dwiputra Hernugrahanto, Dwikora Novembri Utomo, Nicolaas Cyrillus Budhiparama, Ahmad Dzulfikri Nurhan, Mahardian Rahmadi, Dodi Nandika, Lina Karlinasari, Arinana Arinana, Irmanida Batubara, Lucia Dhiantika Witasari, Yanti Rachmayanti, Dikhi Firmasyah, Sairah Abdul Karim, Indang Ariati Ariffin, and Djoko Santoso. "Ethyl acetate extract of fungus comb from Malayan termite (Macrotermes gilvus Hagen) mound modulates splenic inflammatory responses in mice." Open Veterinary Journal 14.9 (2024), 2269-2279. Print. doi:10.5455/OVJ.2024.v14.i9.15


APA (American Psychological Association) Style

Susanto, H., Caesario, . J., Hertanto, . D. M., Sudiana, . K., Hernugrahanto, . K. D., Utomo, . D. N., Budhiparama, . N. C., Nurhan, . A. D., Rahmadi, . M., Nandika, . D., Karlinasari, . L., Arinana, . A., Batubara, . I., Witasari, . L. D., Rachmayanti, . Y., Firmasyah, . D., Karim, . S. A., Ariffin, . I. A. & Santoso, . D. (2024) Ethyl acetate extract of fungus comb from Malayan termite (Macrotermes gilvus Hagen) mound modulates splenic inflammatory responses in mice. Open Veterinary Journal, 14 (9), 2269-2279. doi:10.5455/OVJ.2024.v14.i9.15


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