E-ISSN 2218-6050 | ISSN 2226-4485
 

Research Article


The effect of aluminum chloride on testicular biometry, hormonal profiles, spermatozoa quality, and spermatogenic cells morphology in mice

Zakiyatul Faizah, Hendy Hendarto.


Abstract
Background:
Infertility is defined as failure to achieve a pregnancy after 12 months or more of regular unprotected sexual intercourse. The prevalence of couples with infertility increased every year. Treatment success for male infertility remains suboptimal despite the advancements of the therapies. Hence, a comprehensive understanding regarding spermatogenesis is needed to improve existing infertility treatments. Animal models are commonly used in studies regarding male infertility. Aluminum chloride (AlCl3) has been established as an infertility-inducing agent.
Aim:
This study investigates the optimal dosage of AlCl3 in infertility mice model.
Method:
Male Balb/c mice, aged 3 months and have proven to be fertile with an average body weight of 26,96, randomly assigned to four groups. The control group received oral gavage with sterile aquadest, while the treatment groups were administrated AlCl3 at doses of 100mg/kgBW, 150mg/kg BW, 200mg/kg BW orally over a 53-day period. Assessment of the sperm motility, concentration, morphology, viability, hormone levels, and testicular histopathology were included in this study.
Results:
Administration of AlCl3 did not significantly affect body weight, testicular weight, and hormone levels. However, semen analysis showed a reduction in seminal parameters among treatment groups, supported by testicular histopathology.
Conclusion:
Utilizing AlCl3 to induce infertility in mice models is not quite effective and displayed variable efficacy across different dosage. Further investigations are needed to elucidate optimal dosage, route of administration, and timing to establish reliable mice infertility models.

Key words: Aluminum chloride, Spermatozoa quality, Spermatogenesis, Reproductive health


 
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How to Cite this Article
Pubmed Style

Faizah Z, Hendarto H. The effect of aluminum chloride on testicular biometry, hormonal profiles, spermatozoa quality, and spermatogenic cells morphology in mice. Open Vet J. 2024; 14(9): 2315-2324. doi:10.5455/OVJ.2024.v14.i9.20


Web Style

Faizah Z, Hendarto H. The effect of aluminum chloride on testicular biometry, hormonal profiles, spermatozoa quality, and spermatogenic cells morphology in mice. https://www.openveterinaryjournal.com/?mno=202443 [Access: October 10, 2024]. doi:10.5455/OVJ.2024.v14.i9.20


AMA (American Medical Association) Style

Faizah Z, Hendarto H. The effect of aluminum chloride on testicular biometry, hormonal profiles, spermatozoa quality, and spermatogenic cells morphology in mice. Open Vet J. 2024; 14(9): 2315-2324. doi:10.5455/OVJ.2024.v14.i9.20



Vancouver/ICMJE Style

Faizah Z, Hendarto H. The effect of aluminum chloride on testicular biometry, hormonal profiles, spermatozoa quality, and spermatogenic cells morphology in mice. Open Vet J. (2024), [cited October 10, 2024]; 14(9): 2315-2324. doi:10.5455/OVJ.2024.v14.i9.20



Harvard Style

Faizah, Z. & Hendarto, . H. (2024) The effect of aluminum chloride on testicular biometry, hormonal profiles, spermatozoa quality, and spermatogenic cells morphology in mice. Open Vet J, 14 (9), 2315-2324. doi:10.5455/OVJ.2024.v14.i9.20



Turabian Style

Faizah, Zakiyatul, and Hendy Hendarto. 2024. The effect of aluminum chloride on testicular biometry, hormonal profiles, spermatozoa quality, and spermatogenic cells morphology in mice. Open Veterinary Journal, 14 (9), 2315-2324. doi:10.5455/OVJ.2024.v14.i9.20



Chicago Style

Faizah, Zakiyatul, and Hendy Hendarto. "The effect of aluminum chloride on testicular biometry, hormonal profiles, spermatozoa quality, and spermatogenic cells morphology in mice." Open Veterinary Journal 14 (2024), 2315-2324. doi:10.5455/OVJ.2024.v14.i9.20



MLA (The Modern Language Association) Style

Faizah, Zakiyatul, and Hendy Hendarto. "The effect of aluminum chloride on testicular biometry, hormonal profiles, spermatozoa quality, and spermatogenic cells morphology in mice." Open Veterinary Journal 14.9 (2024), 2315-2324. Print. doi:10.5455/OVJ.2024.v14.i9.20



APA (American Psychological Association) Style

Faizah, Z. & Hendarto, . H. (2024) The effect of aluminum chloride on testicular biometry, hormonal profiles, spermatozoa quality, and spermatogenic cells morphology in mice. Open Veterinary Journal, 14 (9), 2315-2324. doi:10.5455/OVJ.2024.v14.i9.20